The Loss of Expression of Transforming Growth Factor-β Receptors Correlates with the Histopathologic Tumor Grade in Bladder Transitional Cell Carcinoma Patients

Dong Hyeon Lee, Seung Choul Yang, Sung Joon Hong, Byung Ha Chung, Hyun Jik Chung, Hideo Tokunaga, Isaac Y. Kim, Yun S. Song, Seth P. Lerner, Ronald A. Morton

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Transforming growth factor-β (TGF-β), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss of sensitivity to TGF- β through a loss of expression of TGF-β receptors TβSR-I and TβR-II - is associated with tumor initiation and progression. Therefore, to investigate the relationship between TGF-β receptors expression and carcinogenesis of bladder TCC, this study examined the expression of TβR-I and TβR-II in 46 bladder TCC patients using immunohistochemistry. Since histopathological grade is a widely accepted marker of prognosis, the results were compared in relation to the three grades of bladder TCC. The results demonstrated that the loss of TGF-β receptors expression is associated with increasing histopathological grades of bladder TCC. Specifically, both TβR-I and TβR-II were readily detected in all 10 normal bladder mucosa specimens. Likewise, all 6 specimens of grade I TCC samples expressed high levels of both TGF-β receptors. However, among grade II TCC samples, TβR-I and TβR-II were detected in 78% and 89%, respectively: among grade III TCC samples, TβR-I and TβR-II were detected in 45% and 41%, respectively. These results suggested that loss of sensitivity to TGF-β may play a role in the progression of TCC from low to high grade disease.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalYonsei medical journal
Issue number2
Publication statusPublished - 1999 Apr


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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