The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin cofactor II

Seon Joo Yoon, Mariana S. Pereira, Mauro S.G. Pavão, Jae Kwan Hwang, Yu Ryang Pyun, Paulo A.S. Mourão

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We searched for polysaccharides with anticoagulant activity and inhibitory action on platelet aggregation induced by collagen in 59 species of medicinal plants. We then concentrated our studies on the polysaccharide from the species Porana volubilis, which showed the highest anticoagulant activity among the plants tested. The polysaccharide from this species has an average molecular mass of ∼10 kDa, contains mainly galactose, galacturonic acid, and mannose but no sulfate esters. Its anticoagulant activity is mediated by the enhancement of thrombin inhibition that in turn is mediated by heparin cofactor II but not by antithrombin. The galacturonic acid residues are essential for activity since after reduction of its carboxyl groups the anticoagulant activity disappears. Our report is the first description of a natural nonsulfated polysaccharide from higher plants with anticoagulant activity, which may constitute a new source of compounds with action on coagulation and, perhaps, on thrombosis.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalThrombosis Research
Volume106
Issue number1
DOIs
Publication statusPublished - 2002 Apr 1

All Science Journal Classification (ASJC) codes

  • Hematology

Fingerprint Dive into the research topics of 'The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin cofactor II'. Together they form a unique fingerprint.

  • Cite this