The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin cofactor II

Seon Joo Yoon, Mariana S. Pereira, Mauro S.G. Pavão, Jae Kwan Hwang, Yu Ryang Pyun, Paulo A.S. Mourão

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We searched for polysaccharides with anticoagulant activity and inhibitory action on platelet aggregation induced by collagen in 59 species of medicinal plants. We then concentrated our studies on the polysaccharide from the species Porana volubilis, which showed the highest anticoagulant activity among the plants tested. The polysaccharide from this species has an average molecular mass of ∼10 kDa, contains mainly galactose, galacturonic acid, and mannose but no sulfate esters. Its anticoagulant activity is mediated by the enhancement of thrombin inhibition that in turn is mediated by heparin cofactor II but not by antithrombin. The galacturonic acid residues are essential for activity since after reduction of its carboxyl groups the anticoagulant activity disappears. Our report is the first description of a natural nonsulfated polysaccharide from higher plants with anticoagulant activity, which may constitute a new source of compounds with action on coagulation and, perhaps, on thrombosis.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalThrombosis Research
Volume106
Issue number1
DOIs
Publication statusPublished - 2002 Apr 1

Fingerprint

Heparin Cofactor II
Medicinal Plants
Anticoagulants
Polysaccharides
Antithrombins
Mannose
Galactose
Platelet Aggregation
Thrombin
Sulfates
Esters
Thrombosis
Collagen

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Yoon, Seon Joo ; Pereira, Mariana S. ; Pavão, Mauro S.G. ; Hwang, Jae Kwan ; Pyun, Yu Ryang ; Mourão, Paulo A.S. / The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin cofactor II. In: Thrombosis Research. 2002 ; Vol. 106, No. 1. pp. 51-58.
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The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin cofactor II. / Yoon, Seon Joo; Pereira, Mariana S.; Pavão, Mauro S.G.; Hwang, Jae Kwan; Pyun, Yu Ryang; Mourão, Paulo A.S.

In: Thrombosis Research, Vol. 106, No. 1, 01.04.2002, p. 51-58.

Research output: Contribution to journalArticle

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