The methylenetetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other populations

Sun Ha Jee, Terri H. Beaty, Il Suh, Youngsup Yoon, Lawrence J. Appel

Research output: Contribution to journalArticle

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Abstract

The methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased risk for cardiovascular disease in some, but not all studies. Our data sources included a MEDLINE search of the literature published before December 1998, a bibliography review, and expert consultation. Of 23 studies initially identified, 18 (9855 persons) met the inclusion criteria. Information on sample size, study design, Hardy-Weinberg equilibrium, method of genotype determination, plasma folate and homocysteine were abstracted by two reviewers using a standardized protocol. The overall odds ratio of the MTHFR gene on cardiovascular disease was estimated using the Mantel-Haenzel method. From 12 studies with angiographically-confirmed coronary artery disease (CAD), the overall odds ratio (OR) for CAD among those with heterozygous (V/A) was 1.3 (95% CI, 1.1-1.5), while it was 1.4 (1.2-1.6) for the homozygous mutant (V/V) compared to those with homozygous normal (A/A). However, the overall odds ratio for CAD among those with the V/V genotype versus A/A genotype was not statistically significant (OR: 1.1; 95% CI: 0.9-1.3) after excluding three Japanese studies. The corresponding OR for the three Japanese studies was 2.0 (1.6-2.7). For six studies with myocardial infarction (MI), the overall OR of MI was 1.0 (0.8-1.1) for those with the V/A genotype and 0.9 (0.7-1.1) for those with the V/V genotype, respectively; none of these ORs for MI was statistically significant. The MTHFR gene is associated with increased risk for CAD in Japan, but not in other populations. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalAtherosclerosis
Volume153
Issue number1
DOIs
Publication statusPublished - 2000 Oct 30

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Methylenetetrahydrofolate Reductase (NADPH2)
Japan
Odds Ratio
Coronary Artery Disease
Genotype
Population
Genes
Myocardial Infarction
Cardiovascular Diseases
Genotyping Techniques
Information Storage and Retrieval
Bibliography
Homocysteine
Folic Acid
MEDLINE
Sample Size
Referral and Consultation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "The methylenetetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other populations",
abstract = "The methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased risk for cardiovascular disease in some, but not all studies. Our data sources included a MEDLINE search of the literature published before December 1998, a bibliography review, and expert consultation. Of 23 studies initially identified, 18 (9855 persons) met the inclusion criteria. Information on sample size, study design, Hardy-Weinberg equilibrium, method of genotype determination, plasma folate and homocysteine were abstracted by two reviewers using a standardized protocol. The overall odds ratio of the MTHFR gene on cardiovascular disease was estimated using the Mantel-Haenzel method. From 12 studies with angiographically-confirmed coronary artery disease (CAD), the overall odds ratio (OR) for CAD among those with heterozygous (V/A) was 1.3 (95{\%} CI, 1.1-1.5), while it was 1.4 (1.2-1.6) for the homozygous mutant (V/V) compared to those with homozygous normal (A/A). However, the overall odds ratio for CAD among those with the V/V genotype versus A/A genotype was not statistically significant (OR: 1.1; 95{\%} CI: 0.9-1.3) after excluding three Japanese studies. The corresponding OR for the three Japanese studies was 2.0 (1.6-2.7). For six studies with myocardial infarction (MI), the overall OR of MI was 1.0 (0.8-1.1) for those with the V/A genotype and 0.9 (0.7-1.1) for those with the V/V genotype, respectively; none of these ORs for MI was statistically significant. The MTHFR gene is associated with increased risk for CAD in Japan, but not in other populations. Copyright (C) 2000 Elsevier Science Ireland Ltd.",
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The methylenetetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other populations. / Jee, Sun Ha; Beaty, Terri H.; Suh, Il; Yoon, Youngsup; Appel, Lawrence J.

In: Atherosclerosis, Vol. 153, No. 1, 30.10.2000, p. 161-168.

Research output: Contribution to journalArticle

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