The mid-range of the adjusted level of ferritin can predict the chronic course in patients with adult onset Still's disease

Sang Won Lee, Yong Beom Park, Jung Soo Song, Soo Kon Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective. To find a measure that can predict the disease course in patients with adult onset Still's disease (AOSD). Methods. We retrospectively investigated the medical records of 71 hospitalized patients with AOSD. Patients were divided according to chronic and nonchronic disease course. The initial laboratory results were defined as those at the time of admission, the extremely deviated laboratory results as the highest or the lowest results, and the adjusted laboratory results as area under the curve divided by the days of hospitalization. All measures were compared and the odds ratio (OR) for the chronic disease pattern was assessed. Results. The mean age was 39.7 ± 13.5 years and women accounted for 63 of the total 71 (88.7%). Thirty patients (42.3%) had self-limited disease, 9 (12.7%) intermittent disease, and 23 (32.4%) the chronic disease pattern (32.4%). Nine patients (12.7%) died. The initial levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and ferritin, the highest levels of lactate dehydrogenase (LDH) and ferritin, and the adjusted level of ferritin in patients with chronic disease were significantly higher than those with nonchronic disease. Among them, only the middle range of the adjusted ferritin level (784.1∼4120.0 ng/ml) was found to have a significant predictive value for the chronic disease pattern (OR 81.7, p = 0.007). Conclusion. A novel measure, the adjusted level of ferritin during the first hospitalization, might be useful to predict progression to chronic disease in patients with AOSD. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalJournal of Rheumatology
Volume36
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Adult-Onset Still's Disease
Ferritins
Chronic Disease
Hospitalization
Odds Ratio
Rheumatology
Aspartate Aminotransferases
Alanine Transaminase
L-Lactate Dehydrogenase
Area Under Curve
Medical Records

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

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title = "The mid-range of the adjusted level of ferritin can predict the chronic course in patients with adult onset Still's disease",
abstract = "Objective. To find a measure that can predict the disease course in patients with adult onset Still's disease (AOSD). Methods. We retrospectively investigated the medical records of 71 hospitalized patients with AOSD. Patients were divided according to chronic and nonchronic disease course. The initial laboratory results were defined as those at the time of admission, the extremely deviated laboratory results as the highest or the lowest results, and the adjusted laboratory results as area under the curve divided by the days of hospitalization. All measures were compared and the odds ratio (OR) for the chronic disease pattern was assessed. Results. The mean age was 39.7 ± 13.5 years and women accounted for 63 of the total 71 (88.7{\%}). Thirty patients (42.3{\%}) had self-limited disease, 9 (12.7{\%}) intermittent disease, and 23 (32.4{\%}) the chronic disease pattern (32.4{\%}). Nine patients (12.7{\%}) died. The initial levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and ferritin, the highest levels of lactate dehydrogenase (LDH) and ferritin, and the adjusted level of ferritin in patients with chronic disease were significantly higher than those with nonchronic disease. Among them, only the middle range of the adjusted ferritin level (784.1∼4120.0 ng/ml) was found to have a significant predictive value for the chronic disease pattern (OR 81.7, p = 0.007). Conclusion. A novel measure, the adjusted level of ferritin during the first hospitalization, might be useful to predict progression to chronic disease in patients with AOSD. The Journal of Rheumatology",
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The mid-range of the adjusted level of ferritin can predict the chronic course in patients with adult onset Still's disease. / Lee, Sang Won; Park, Yong Beom; Song, Jung Soo; Lee, Soo Kon.

In: Journal of Rheumatology, Vol. 36, No. 1, 01.01.2009, p. 156-162.

Research output: Contribution to journalArticle

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N2 - Objective. To find a measure that can predict the disease course in patients with adult onset Still's disease (AOSD). Methods. We retrospectively investigated the medical records of 71 hospitalized patients with AOSD. Patients were divided according to chronic and nonchronic disease course. The initial laboratory results were defined as those at the time of admission, the extremely deviated laboratory results as the highest or the lowest results, and the adjusted laboratory results as area under the curve divided by the days of hospitalization. All measures were compared and the odds ratio (OR) for the chronic disease pattern was assessed. Results. The mean age was 39.7 ± 13.5 years and women accounted for 63 of the total 71 (88.7%). Thirty patients (42.3%) had self-limited disease, 9 (12.7%) intermittent disease, and 23 (32.4%) the chronic disease pattern (32.4%). Nine patients (12.7%) died. The initial levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and ferritin, the highest levels of lactate dehydrogenase (LDH) and ferritin, and the adjusted level of ferritin in patients with chronic disease were significantly higher than those with nonchronic disease. Among them, only the middle range of the adjusted ferritin level (784.1∼4120.0 ng/ml) was found to have a significant predictive value for the chronic disease pattern (OR 81.7, p = 0.007). Conclusion. A novel measure, the adjusted level of ferritin during the first hospitalization, might be useful to predict progression to chronic disease in patients with AOSD. The Journal of Rheumatology

AB - Objective. To find a measure that can predict the disease course in patients with adult onset Still's disease (AOSD). Methods. We retrospectively investigated the medical records of 71 hospitalized patients with AOSD. Patients were divided according to chronic and nonchronic disease course. The initial laboratory results were defined as those at the time of admission, the extremely deviated laboratory results as the highest or the lowest results, and the adjusted laboratory results as area under the curve divided by the days of hospitalization. All measures were compared and the odds ratio (OR) for the chronic disease pattern was assessed. Results. The mean age was 39.7 ± 13.5 years and women accounted for 63 of the total 71 (88.7%). Thirty patients (42.3%) had self-limited disease, 9 (12.7%) intermittent disease, and 23 (32.4%) the chronic disease pattern (32.4%). Nine patients (12.7%) died. The initial levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and ferritin, the highest levels of lactate dehydrogenase (LDH) and ferritin, and the adjusted level of ferritin in patients with chronic disease were significantly higher than those with nonchronic disease. Among them, only the middle range of the adjusted ferritin level (784.1∼4120.0 ng/ml) was found to have a significant predictive value for the chronic disease pattern (OR 81.7, p = 0.007). Conclusion. A novel measure, the adjusted level of ferritin during the first hospitalization, might be useful to predict progression to chronic disease in patients with AOSD. The Journal of Rheumatology

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