The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4

Su Jung Lee, Kyung Tae Noh, Tae Heung Kang, Hee Dong Han, Sung Jae Shin, Byoung Yul Soh, Jung Hee Park, Yong Kyoo Shin, Han Wool Kim, Cheol Heui Yun, Won Sun Park, In Duk Jung, Yeong Min Park

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12 Citations (Scopus)

Abstract

In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-α, and IL-1β) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform naive T cells to polarized CD4+ and CD8+ T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. paratuberculosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of CD4+ and CD8+ T cells.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalBMB reports
Volume47
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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    Lee, S. J., Noh, K. T., Kang, T. H., Han, H. D., Shin, S. J., Soh, B. Y., Park, J. H., Shin, Y. K., Kim, H. W., Yun, C. H., Park, W. S., Jung, I. D., & Park, Y. M. (2014). The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4. BMB reports, 47(2), 115-120. https://doi.org/10.5483/BMBRep.2014.47.2.277