The neural basis of a deficit in abstract thinking in patients with schizophrenia

Jooyoung Oh, Ji Won Chun, Hang Joon Jo, Eunseong Kim, Hae Jeong Park, Boreom Lee, Jae-Jin Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Abnormal abstract thinking is a major cause of social dysfunction in patients with schizophrenia, but little is known about its neural basis. In this study, we aimed to determine the characteristic abstract thinking-related brain responses in patients using a task reflecting social situations. We conducted functional magnetic resonance imaging while 16 patients with schizophrenia and 16 healthy controls performed a theme-identification task, in which various emotional pictures depicting social situations were presented. Compared with healthy controls, the patients showed significantly decreased activity in the left frontopolar and right orbitofrontal cortices during theme identification. Activity in these two regions correlated well in the controls, but not in patients. Instead, the patients exhibited a close correlation between activity in both sides of the frontopolar cortex, and a positive correlation between the right orbitofrontal cortex activity and degrees of theme identification. Reduced activity in the left frontopolar and right orbitofrontal cortices and the underlying aberrant connectivity may be implicated in the patients' deficits in abstract thinking. These newly identified features of the neural basis of abnormal abstract thinking are important as they have implications for the impaired social behavior of patients with schizophrenia during real-life situations.

Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume234
Issue number1
DOIs
Publication statusPublished - 2015 Oct 30

Fingerprint

Schizophrenia
Prefrontal Cortex
Thinking
Social Behavior
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Oh, Jooyoung ; Chun, Ji Won ; Joon Jo, Hang ; Kim, Eunseong ; Park, Hae Jeong ; Lee, Boreom ; Kim, Jae-Jin. / The neural basis of a deficit in abstract thinking in patients with schizophrenia. In: Psychiatry Research - Neuroimaging. 2015 ; Vol. 234, No. 1. pp. 66-73.
@article{540b0151bcf0452e9731eb9d0e068457,
title = "The neural basis of a deficit in abstract thinking in patients with schizophrenia",
abstract = "Abnormal abstract thinking is a major cause of social dysfunction in patients with schizophrenia, but little is known about its neural basis. In this study, we aimed to determine the characteristic abstract thinking-related brain responses in patients using a task reflecting social situations. We conducted functional magnetic resonance imaging while 16 patients with schizophrenia and 16 healthy controls performed a theme-identification task, in which various emotional pictures depicting social situations were presented. Compared with healthy controls, the patients showed significantly decreased activity in the left frontopolar and right orbitofrontal cortices during theme identification. Activity in these two regions correlated well in the controls, but not in patients. Instead, the patients exhibited a close correlation between activity in both sides of the frontopolar cortex, and a positive correlation between the right orbitofrontal cortex activity and degrees of theme identification. Reduced activity in the left frontopolar and right orbitofrontal cortices and the underlying aberrant connectivity may be implicated in the patients' deficits in abstract thinking. These newly identified features of the neural basis of abnormal abstract thinking are important as they have implications for the impaired social behavior of patients with schizophrenia during real-life situations.",
author = "Jooyoung Oh and Chun, {Ji Won} and {Joon Jo}, Hang and Eunseong Kim and Park, {Hae Jeong} and Boreom Lee and Jae-Jin Kim",
year = "2015",
month = "10",
day = "30",
doi = "10.1016/j.pscychresns.2015.08.007",
language = "English",
volume = "234",
pages = "66--73",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

The neural basis of a deficit in abstract thinking in patients with schizophrenia. / Oh, Jooyoung; Chun, Ji Won; Joon Jo, Hang; Kim, Eunseong; Park, Hae Jeong; Lee, Boreom; Kim, Jae-Jin.

In: Psychiatry Research - Neuroimaging, Vol. 234, No. 1, 30.10.2015, p. 66-73.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The neural basis of a deficit in abstract thinking in patients with schizophrenia

AU - Oh, Jooyoung

AU - Chun, Ji Won

AU - Joon Jo, Hang

AU - Kim, Eunseong

AU - Park, Hae Jeong

AU - Lee, Boreom

AU - Kim, Jae-Jin

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Abnormal abstract thinking is a major cause of social dysfunction in patients with schizophrenia, but little is known about its neural basis. In this study, we aimed to determine the characteristic abstract thinking-related brain responses in patients using a task reflecting social situations. We conducted functional magnetic resonance imaging while 16 patients with schizophrenia and 16 healthy controls performed a theme-identification task, in which various emotional pictures depicting social situations were presented. Compared with healthy controls, the patients showed significantly decreased activity in the left frontopolar and right orbitofrontal cortices during theme identification. Activity in these two regions correlated well in the controls, but not in patients. Instead, the patients exhibited a close correlation between activity in both sides of the frontopolar cortex, and a positive correlation between the right orbitofrontal cortex activity and degrees of theme identification. Reduced activity in the left frontopolar and right orbitofrontal cortices and the underlying aberrant connectivity may be implicated in the patients' deficits in abstract thinking. These newly identified features of the neural basis of abnormal abstract thinking are important as they have implications for the impaired social behavior of patients with schizophrenia during real-life situations.

AB - Abnormal abstract thinking is a major cause of social dysfunction in patients with schizophrenia, but little is known about its neural basis. In this study, we aimed to determine the characteristic abstract thinking-related brain responses in patients using a task reflecting social situations. We conducted functional magnetic resonance imaging while 16 patients with schizophrenia and 16 healthy controls performed a theme-identification task, in which various emotional pictures depicting social situations were presented. Compared with healthy controls, the patients showed significantly decreased activity in the left frontopolar and right orbitofrontal cortices during theme identification. Activity in these two regions correlated well in the controls, but not in patients. Instead, the patients exhibited a close correlation between activity in both sides of the frontopolar cortex, and a positive correlation between the right orbitofrontal cortex activity and degrees of theme identification. Reduced activity in the left frontopolar and right orbitofrontal cortices and the underlying aberrant connectivity may be implicated in the patients' deficits in abstract thinking. These newly identified features of the neural basis of abnormal abstract thinking are important as they have implications for the impaired social behavior of patients with schizophrenia during real-life situations.

UR - http://www.scopus.com/inward/record.url?scp=84948710528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948710528&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2015.08.007

DO - 10.1016/j.pscychresns.2015.08.007

M3 - Article

VL - 234

SP - 66

EP - 73

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 1

ER -