The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are prognostic factors in patients with locally advanced pancreatic cancer treated with chemoradiotherapy

Byung Min Lee, Seung Yeun Chung, Jee Suk Chang, Kyong Joo Lee, Jinsil Seong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Aims: We investigated whether inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and platelet- lymphocyte ratio (PLR) independently and in combination would be significant prognostic factors for survival in patients with locally advanced pancreatic cancer. Methods: A total of 497 patients with locally advanced pancreatic cancer who received neoadjuvant or definitive chemoradiotherapy from 2005 to 2015 were evaluated. We divided the patients into groups according to the median values of NLR and PLR: NLR<1.89 (n=156), NLR≥1.89 (n=341), PLR <149 (n=248) and PLR ≥149 (n=249). Results: For NLR <1.89 and ≥1.89 groups, respectively, the 1-year overall survival (OS) rates were 73.2% and 60.8% (p<0.001) and 1-year progressionfree survival (PFS) rates were 43.9% and 31.3% (p<0.001). For PLR <149 and ≥149 groups, respectively, the 1-year OS rates were 68.1% and 61.3% (p=0.029) and 1-year PFS rates were 37.9% and 32.5% (p=0.027). Patients with both high NLR and high PLR showed the worst OS and PFS rates compared with those with both lower NLR and lower PLR. Conclusions: Elevated pretreatment NLR and PLR independently and in combination significantly predicted poor OS and PFS.

Original languageEnglish
Pages (from-to)342-352
Number of pages11
JournalGut and liver
Volume12
Issue number3
DOIs
Publication statusPublished - 2018 May

Fingerprint

Chemoradiotherapy
Pancreatic Neoplasms
Neutrophils
Blood Platelets
Lymphocytes
Survival Rate
Survival

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{afcdb1fbf1e848f898015958a7ff6e59,
title = "The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are prognostic factors in patients with locally advanced pancreatic cancer treated with chemoradiotherapy",
abstract = "Background/Aims: We investigated whether inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and platelet- lymphocyte ratio (PLR) independently and in combination would be significant prognostic factors for survival in patients with locally advanced pancreatic cancer. Methods: A total of 497 patients with locally advanced pancreatic cancer who received neoadjuvant or definitive chemoradiotherapy from 2005 to 2015 were evaluated. We divided the patients into groups according to the median values of NLR and PLR: NLR<1.89 (n=156), NLR≥1.89 (n=341), PLR <149 (n=248) and PLR ≥149 (n=249). Results: For NLR <1.89 and ≥1.89 groups, respectively, the 1-year overall survival (OS) rates were 73.2{\%} and 60.8{\%} (p<0.001) and 1-year progressionfree survival (PFS) rates were 43.9{\%} and 31.3{\%} (p<0.001). For PLR <149 and ≥149 groups, respectively, the 1-year OS rates were 68.1{\%} and 61.3{\%} (p=0.029) and 1-year PFS rates were 37.9{\%} and 32.5{\%} (p=0.027). Patients with both high NLR and high PLR showed the worst OS and PFS rates compared with those with both lower NLR and lower PLR. Conclusions: Elevated pretreatment NLR and PLR independently and in combination significantly predicted poor OS and PFS.",
author = "Lee, {Byung Min} and Chung, {Seung Yeun} and Chang, {Jee Suk} and Lee, {Kyong Joo} and Jinsil Seong",
year = "2018",
month = "5",
doi = "10.5009/gnl17216",
language = "English",
volume = "12",
pages = "342--352",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "3",

}

The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are prognostic factors in patients with locally advanced pancreatic cancer treated with chemoradiotherapy. / Lee, Byung Min; Chung, Seung Yeun; Chang, Jee Suk; Lee, Kyong Joo; Seong, Jinsil.

In: Gut and liver, Vol. 12, No. 3, 05.2018, p. 342-352.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are prognostic factors in patients with locally advanced pancreatic cancer treated with chemoradiotherapy

AU - Lee, Byung Min

AU - Chung, Seung Yeun

AU - Chang, Jee Suk

AU - Lee, Kyong Joo

AU - Seong, Jinsil

PY - 2018/5

Y1 - 2018/5

N2 - Background/Aims: We investigated whether inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and platelet- lymphocyte ratio (PLR) independently and in combination would be significant prognostic factors for survival in patients with locally advanced pancreatic cancer. Methods: A total of 497 patients with locally advanced pancreatic cancer who received neoadjuvant or definitive chemoradiotherapy from 2005 to 2015 were evaluated. We divided the patients into groups according to the median values of NLR and PLR: NLR<1.89 (n=156), NLR≥1.89 (n=341), PLR <149 (n=248) and PLR ≥149 (n=249). Results: For NLR <1.89 and ≥1.89 groups, respectively, the 1-year overall survival (OS) rates were 73.2% and 60.8% (p<0.001) and 1-year progressionfree survival (PFS) rates were 43.9% and 31.3% (p<0.001). For PLR <149 and ≥149 groups, respectively, the 1-year OS rates were 68.1% and 61.3% (p=0.029) and 1-year PFS rates were 37.9% and 32.5% (p=0.027). Patients with both high NLR and high PLR showed the worst OS and PFS rates compared with those with both lower NLR and lower PLR. Conclusions: Elevated pretreatment NLR and PLR independently and in combination significantly predicted poor OS and PFS.

AB - Background/Aims: We investigated whether inflammatory markers such as neutrophil-lymphocyte ratio (NLR) and platelet- lymphocyte ratio (PLR) independently and in combination would be significant prognostic factors for survival in patients with locally advanced pancreatic cancer. Methods: A total of 497 patients with locally advanced pancreatic cancer who received neoadjuvant or definitive chemoradiotherapy from 2005 to 2015 were evaluated. We divided the patients into groups according to the median values of NLR and PLR: NLR<1.89 (n=156), NLR≥1.89 (n=341), PLR <149 (n=248) and PLR ≥149 (n=249). Results: For NLR <1.89 and ≥1.89 groups, respectively, the 1-year overall survival (OS) rates were 73.2% and 60.8% (p<0.001) and 1-year progressionfree survival (PFS) rates were 43.9% and 31.3% (p<0.001). For PLR <149 and ≥149 groups, respectively, the 1-year OS rates were 68.1% and 61.3% (p=0.029) and 1-year PFS rates were 37.9% and 32.5% (p=0.027). Patients with both high NLR and high PLR showed the worst OS and PFS rates compared with those with both lower NLR and lower PLR. Conclusions: Elevated pretreatment NLR and PLR independently and in combination significantly predicted poor OS and PFS.

UR - http://www.scopus.com/inward/record.url?scp=85048728013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048728013&partnerID=8YFLogxK

U2 - 10.5009/gnl17216

DO - 10.5009/gnl17216

M3 - Article

C2 - 29409306

AN - SCOPUS:85048728013

VL - 12

SP - 342

EP - 352

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 3

ER -