The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis

Kyung Tae Lee, Dong Gi Lee, Ji Won Choi, Jong Hyun Park, Ki Duk Park, Jong Seung Lee, Yong Sun Bahn

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic candidiasis, which is mainly caused by Candida albicans, is a serious acute fungal infection in the clinical setting. In a previous study, we reported that compound 22h (designated as AB-22 in this study), a vinyl sulfate compound, is a fast-acting fungicidal agent against a broad spectrum of fungal pathogens. In this study, we aimed to further analyze the in vitro and in vivo efficacy of AB-22 against filamentation, biofilm formation, and virulence of C. albicans. Under in vitro hyphal growth-inducing condition, AB-22 effectively inhibited germ tube formation and hyphal growth, which are required for the initiation of biofilm formation. Indeed, AB-22 significantly suppressed C. albicans biofilm formation in a dose-dependent manner. Moreover, AB-22 treatment inhibited the normal induction of ALS3, HWP1, and ECE1, which are all required for hyphal transition in C. albicans. Furthermore, AB-22 treatment increased the survival of mice systemically infected with C. albicans. In conclusion, in addition to its fungicidal activity, AB-22 inhibits filamentation and biofilm formation in C. albicans, which could collectively contribute to its potent in vivo efficacy against systemic candidiasis.

Original languageEnglish
Pages (from-to)438-443
Number of pages6
JournalJournal of Microbiology
Volume60
Issue number4
DOIs
Publication statusPublished - 2022 Apr

Bibliographical note

Funding Information:
This study was supported by the Korea Health Technology R&D Project (HI20C0326 to J.-S.L. and K.-T.L.) by the Ministry of Health and Welfare, Republic of Korea.

Publisher Copyright:
© 2022, The Microbiological Society of Korea.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Applied Microbiology and Biotechnology

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