The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer

Jeonghee Han, Gyoung Tae Noh, Shen Ann Yeo, Chinock Cheong, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Namkyu Kim

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Abstract

The aim of this study is to investigate if retrieval of 12 lymph nodes (LNs) is sufficient to avoid stage migration as well as to evaluate the prognostic impact of insufficient LN retrieval in different treatment settings of rectal cancer, particularly in the case of preoperative chemoradiotherapy (pCRT). The data of all patients with biopsy proven rectal adenocarcinoma who underwent curative surgery between January 2005 and December 2012 were analyzed. Univariate and multivariate analyses for oncologic outcomes were performed in LN metastasis or no LN metastasis (LN-) group. Subgroup analyses were performed according to whether a patient had received pCRT. A total of 1825 patients were enrolled into the study. The maximal Chi-square method revealed the minimum number of harvested LNs required to be 12. Univariate and multivariate analyses found LNs= 12 to be an independent prognostic factor for both overall survival (OS) (hazard ratio [HR]= 0.5, 95% confidence intervals [CIs]: 0.3-0.8; P= 0.002) and disease-free survival (DFS) (HR=0.6, 95% CI: 0.4-0.7; P< 0.001) in the LN-group. In the LN-group, LNs= 12 continued to be a significant prognostic factor both for OS and DFS in the subgroup of patients who did not undergo pCRT. However, in the subgroup of the LN-patients who underwent pCRT, LN= 8 was significant for DFS and OS. Retrieval of LNs≥12 and LNs≥ 8 should be achieved to obtain accurate staging and optimal treatment for the non-pCRT and pCRT groups in rectal cancer, respectively.

Original languageEnglish
Article numbere4891
JournalMedicine (United States)
Volume95
Issue number38
DOIs
Publication statusPublished - 2016 Jan 1

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Rectal Neoplasms
Lymph Nodes
Chemoradiotherapy
Disease-Free Survival
Survival
Multivariate Analysis
Confidence Intervals
Neoplasm Metastasis
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Han, Jeonghee ; Noh, Gyoung Tae ; Yeo, Shen Ann ; Cheong, Chinock ; Cho, Min Soo ; Hur, Hyuk ; Min, Byung Soh ; Lee, Kang Young ; Kim, Namkyu. / The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer. In: Medicine (United States). 2016 ; Vol. 95, No. 38.
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abstract = "The aim of this study is to investigate if retrieval of 12 lymph nodes (LNs) is sufficient to avoid stage migration as well as to evaluate the prognostic impact of insufficient LN retrieval in different treatment settings of rectal cancer, particularly in the case of preoperative chemoradiotherapy (pCRT). The data of all patients with biopsy proven rectal adenocarcinoma who underwent curative surgery between January 2005 and December 2012 were analyzed. Univariate and multivariate analyses for oncologic outcomes were performed in LN metastasis or no LN metastasis (LN-) group. Subgroup analyses were performed according to whether a patient had received pCRT. A total of 1825 patients were enrolled into the study. The maximal Chi-square method revealed the minimum number of harvested LNs required to be 12. Univariate and multivariate analyses found LNs= 12 to be an independent prognostic factor for both overall survival (OS) (hazard ratio [HR]= 0.5, 95{\%} confidence intervals [CIs]: 0.3-0.8; P= 0.002) and disease-free survival (DFS) (HR=0.6, 95{\%} CI: 0.4-0.7; P< 0.001) in the LN-group. In the LN-group, LNs= 12 continued to be a significant prognostic factor both for OS and DFS in the subgroup of patients who did not undergo pCRT. However, in the subgroup of the LN-patients who underwent pCRT, LN= 8 was significant for DFS and OS. Retrieval of LNs≥12 and LNs≥ 8 should be achieved to obtain accurate staging and optimal treatment for the non-pCRT and pCRT groups in rectal cancer, respectively.",
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The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer. / Han, Jeonghee; Noh, Gyoung Tae; Yeo, Shen Ann; Cheong, Chinock; Cho, Min Soo; Hur, Hyuk; Min, Byung Soh; Lee, Kang Young; Kim, Namkyu.

In: Medicine (United States), Vol. 95, No. 38, e4891, 01.01.2016.

Research output: Contribution to journalArticle

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T1 - The number of retrieved lymph nodes needed for accurate staging differs based on the presence of preoperative chemoradiation for rectal cancer

AU - Han, Jeonghee

AU - Noh, Gyoung Tae

AU - Yeo, Shen Ann

AU - Cheong, Chinock

AU - Cho, Min Soo

AU - Hur, Hyuk

AU - Min, Byung Soh

AU - Lee, Kang Young

AU - Kim, Namkyu

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N2 - The aim of this study is to investigate if retrieval of 12 lymph nodes (LNs) is sufficient to avoid stage migration as well as to evaluate the prognostic impact of insufficient LN retrieval in different treatment settings of rectal cancer, particularly in the case of preoperative chemoradiotherapy (pCRT). The data of all patients with biopsy proven rectal adenocarcinoma who underwent curative surgery between January 2005 and December 2012 were analyzed. Univariate and multivariate analyses for oncologic outcomes were performed in LN metastasis or no LN metastasis (LN-) group. Subgroup analyses were performed according to whether a patient had received pCRT. A total of 1825 patients were enrolled into the study. The maximal Chi-square method revealed the minimum number of harvested LNs required to be 12. Univariate and multivariate analyses found LNs= 12 to be an independent prognostic factor for both overall survival (OS) (hazard ratio [HR]= 0.5, 95% confidence intervals [CIs]: 0.3-0.8; P= 0.002) and disease-free survival (DFS) (HR=0.6, 95% CI: 0.4-0.7; P< 0.001) in the LN-group. In the LN-group, LNs= 12 continued to be a significant prognostic factor both for OS and DFS in the subgroup of patients who did not undergo pCRT. However, in the subgroup of the LN-patients who underwent pCRT, LN= 8 was significant for DFS and OS. Retrieval of LNs≥12 and LNs≥ 8 should be achieved to obtain accurate staging and optimal treatment for the non-pCRT and pCRT groups in rectal cancer, respectively.

AB - The aim of this study is to investigate if retrieval of 12 lymph nodes (LNs) is sufficient to avoid stage migration as well as to evaluate the prognostic impact of insufficient LN retrieval in different treatment settings of rectal cancer, particularly in the case of preoperative chemoradiotherapy (pCRT). The data of all patients with biopsy proven rectal adenocarcinoma who underwent curative surgery between January 2005 and December 2012 were analyzed. Univariate and multivariate analyses for oncologic outcomes were performed in LN metastasis or no LN metastasis (LN-) group. Subgroup analyses were performed according to whether a patient had received pCRT. A total of 1825 patients were enrolled into the study. The maximal Chi-square method revealed the minimum number of harvested LNs required to be 12. Univariate and multivariate analyses found LNs= 12 to be an independent prognostic factor for both overall survival (OS) (hazard ratio [HR]= 0.5, 95% confidence intervals [CIs]: 0.3-0.8; P= 0.002) and disease-free survival (DFS) (HR=0.6, 95% CI: 0.4-0.7; P< 0.001) in the LN-group. In the LN-group, LNs= 12 continued to be a significant prognostic factor both for OS and DFS in the subgroup of patients who did not undergo pCRT. However, in the subgroup of the LN-patients who underwent pCRT, LN= 8 was significant for DFS and OS. Retrieval of LNs≥12 and LNs≥ 8 should be achieved to obtain accurate staging and optimal treatment for the non-pCRT and pCRT groups in rectal cancer, respectively.

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