The optimal dose of remifentanil needed to produce successful intubating conditions following inhalation induction of anaesthesia using 5% sevoflurane without the use of neuromuscular blocking drugs, was investigated in 25 children aged 3-10 years. Sixty seconds after inhalation induction of anaesthesia using sevoflurane 5% in 100% oxygen, a predetermined dose of remifentanil was injected over 30s. The dose of remifentanil was determined using the modified Dixon's up-and-down method (0.2 μg kg-1 as a step size). The first patient was tested at 1.0 μg kg-1 remifentanil. Ninety seconds following the bolus administration of remifentanil, the child's trachea was intubated. The optimal bolus dose of remifentanil required for successful tracheal intubation was 0.56 (0.15) μg kg-1 in 50% of children during inhalation induction using 5% sevoflurane in the absence of neuromuscular blocking drugs. Using probit analysis, the 95% effective dose (ED95) of remifentanil was 0.75 μg kg-1 (95% confidence limits 0.63-1.38 μg kg-1).
All Science Journal Classification (ASJC) codes
- Anesthesiology and Pain Medicine