The optimal serum pepsinogen cut-off value for predicting histologically confirmed atrophic gastritis

Eun Hye Kim, Huapyong Kang, Chan Hyuk Park, Hee Seung Choi, Da Hyun Jung, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, SangKil Lee, Yongchan Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Although serum pepsinogen tests are useful for predicting the presence of atrophic gastritis, the optimal cut-off values have not been fully evaluated. Aim: To determine the optimal serum pepsinogen cut-off value for predicting atrophic gastritis. Methods: Patients scheduled for upper endoscopy at Severance Hospital, Korea, between August 2012 and October 2013, were recruited prospectively. Endoscopic biopsies for atrophic gastritis were obtained and histologically graded, based on the updated Sydney system. Results: Ninety-five patients were enrolled in the study. The mean age was 57.7. ± 12.1 years, and 44.2% of the patients were male. Serum pepsinogen I/II ratios were lower in patients with atrophic gastritis than in those without it (antrum, 4.2. ± 1.7 vs. 5.2. ± 2.1, P= 0.040; corpus, 3.3. ± 1.9 vs. 5.4. ± 1.9, P< 0.001). Serum pepsinogen I/II ratios were significantly correlated with histologic atrophic gastritis (antrum, P= 0.030; corpus, P< 0.001). Using a cut-off value of 4.9, the sensitivity and specificity of the serum pepsinogen I/II ratio for predicting atrophic gastritis in the antrum were 68.2% and 60.3%, respectively. Conclusion: The optimal serum pepsinogen I/II ratio cut-off values for atrophic gastritis of the antrum and for the corpus were 4.9 and 3.5, respectively. Serum pepsinogen I/II ratios, with these cut-off values, are useful for screening patients for the presence of atrophic gastritis.

Original languageEnglish
Pages (from-to)663-668
Number of pages6
JournalDigestive and Liver Disease
Volume47
Issue number8
DOIs
Publication statusPublished - 2015 Aug 1

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Pepsinogen A
Atrophic Gastritis
Pepsinogen C
Serum
Korea
Endoscopy
Biopsy
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, Eun Hye ; Kang, Huapyong ; Park, Chan Hyuk ; Choi, Hee Seung ; Jung, Da Hyun ; Chung, Hyunsoo ; Park, Jun Chul ; Shin, Sung Kwan ; Lee, SangKil ; Lee, Yongchan. / The optimal serum pepsinogen cut-off value for predicting histologically confirmed atrophic gastritis. In: Digestive and Liver Disease. 2015 ; Vol. 47, No. 8. pp. 663-668.
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title = "The optimal serum pepsinogen cut-off value for predicting histologically confirmed atrophic gastritis",
abstract = "Background: Although serum pepsinogen tests are useful for predicting the presence of atrophic gastritis, the optimal cut-off values have not been fully evaluated. Aim: To determine the optimal serum pepsinogen cut-off value for predicting atrophic gastritis. Methods: Patients scheduled for upper endoscopy at Severance Hospital, Korea, between August 2012 and October 2013, were recruited prospectively. Endoscopic biopsies for atrophic gastritis were obtained and histologically graded, based on the updated Sydney system. Results: Ninety-five patients were enrolled in the study. The mean age was 57.7. ± 12.1 years, and 44.2{\%} of the patients were male. Serum pepsinogen I/II ratios were lower in patients with atrophic gastritis than in those without it (antrum, 4.2. ± 1.7 vs. 5.2. ± 2.1, P= 0.040; corpus, 3.3. ± 1.9 vs. 5.4. ± 1.9, P< 0.001). Serum pepsinogen I/II ratios were significantly correlated with histologic atrophic gastritis (antrum, P= 0.030; corpus, P< 0.001). Using a cut-off value of 4.9, the sensitivity and specificity of the serum pepsinogen I/II ratio for predicting atrophic gastritis in the antrum were 68.2{\%} and 60.3{\%}, respectively. Conclusion: The optimal serum pepsinogen I/II ratio cut-off values for atrophic gastritis of the antrum and for the corpus were 4.9 and 3.5, respectively. Serum pepsinogen I/II ratios, with these cut-off values, are useful for screening patients for the presence of atrophic gastritis.",
author = "Kim, {Eun Hye} and Huapyong Kang and Park, {Chan Hyuk} and Choi, {Hee Seung} and Jung, {Da Hyun} and Hyunsoo Chung and Park, {Jun Chul} and Shin, {Sung Kwan} and SangKil Lee and Yongchan Lee",
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The optimal serum pepsinogen cut-off value for predicting histologically confirmed atrophic gastritis. / Kim, Eun Hye; Kang, Huapyong; Park, Chan Hyuk; Choi, Hee Seung; Jung, Da Hyun; Chung, Hyunsoo; Park, Jun Chul; Shin, Sung Kwan; Lee, SangKil; Lee, Yongchan.

In: Digestive and Liver Disease, Vol. 47, No. 8, 01.08.2015, p. 663-668.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The optimal serum pepsinogen cut-off value for predicting histologically confirmed atrophic gastritis

AU - Kim, Eun Hye

AU - Kang, Huapyong

AU - Park, Chan Hyuk

AU - Choi, Hee Seung

AU - Jung, Da Hyun

AU - Chung, Hyunsoo

AU - Park, Jun Chul

AU - Shin, Sung Kwan

AU - Lee, SangKil

AU - Lee, Yongchan

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background: Although serum pepsinogen tests are useful for predicting the presence of atrophic gastritis, the optimal cut-off values have not been fully evaluated. Aim: To determine the optimal serum pepsinogen cut-off value for predicting atrophic gastritis. Methods: Patients scheduled for upper endoscopy at Severance Hospital, Korea, between August 2012 and October 2013, were recruited prospectively. Endoscopic biopsies for atrophic gastritis were obtained and histologically graded, based on the updated Sydney system. Results: Ninety-five patients were enrolled in the study. The mean age was 57.7. ± 12.1 years, and 44.2% of the patients were male. Serum pepsinogen I/II ratios were lower in patients with atrophic gastritis than in those without it (antrum, 4.2. ± 1.7 vs. 5.2. ± 2.1, P= 0.040; corpus, 3.3. ± 1.9 vs. 5.4. ± 1.9, P< 0.001). Serum pepsinogen I/II ratios were significantly correlated with histologic atrophic gastritis (antrum, P= 0.030; corpus, P< 0.001). Using a cut-off value of 4.9, the sensitivity and specificity of the serum pepsinogen I/II ratio for predicting atrophic gastritis in the antrum were 68.2% and 60.3%, respectively. Conclusion: The optimal serum pepsinogen I/II ratio cut-off values for atrophic gastritis of the antrum and for the corpus were 4.9 and 3.5, respectively. Serum pepsinogen I/II ratios, with these cut-off values, are useful for screening patients for the presence of atrophic gastritis.

AB - Background: Although serum pepsinogen tests are useful for predicting the presence of atrophic gastritis, the optimal cut-off values have not been fully evaluated. Aim: To determine the optimal serum pepsinogen cut-off value for predicting atrophic gastritis. Methods: Patients scheduled for upper endoscopy at Severance Hospital, Korea, between August 2012 and October 2013, were recruited prospectively. Endoscopic biopsies for atrophic gastritis were obtained and histologically graded, based on the updated Sydney system. Results: Ninety-five patients were enrolled in the study. The mean age was 57.7. ± 12.1 years, and 44.2% of the patients were male. Serum pepsinogen I/II ratios were lower in patients with atrophic gastritis than in those without it (antrum, 4.2. ± 1.7 vs. 5.2. ± 2.1, P= 0.040; corpus, 3.3. ± 1.9 vs. 5.4. ± 1.9, P< 0.001). Serum pepsinogen I/II ratios were significantly correlated with histologic atrophic gastritis (antrum, P= 0.030; corpus, P< 0.001). Using a cut-off value of 4.9, the sensitivity and specificity of the serum pepsinogen I/II ratio for predicting atrophic gastritis in the antrum were 68.2% and 60.3%, respectively. Conclusion: The optimal serum pepsinogen I/II ratio cut-off values for atrophic gastritis of the antrum and for the corpus were 4.9 and 3.5, respectively. Serum pepsinogen I/II ratios, with these cut-off values, are useful for screening patients for the presence of atrophic gastritis.

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