The origin of pre-neoplastic metaplasia in the stomach: Chief cells emerge from the Mist

James R. Goldenring; Ki Taek Nam; Jason C. Mills

doi:10.1016/j.yexcr.2011.08.017

The origin of pre-neoplastic metaplasia in the stomach: Chief cells emerge from the Mist

James R. Goldenring, Ki Taek Nam, Jason C. Mills

BioMedical Science Institute

Research output: Contribution to journal › Review article › peer-review

68 Citations (Scopus)

Abstract

The digestive-enzyme secreting, gastric epithelial chief (zymogenic) cell is remarkable and underappreciated. Here, we discuss how all available evidence suggests that mature chief cells in the adult, mammalian stomach are postmitotic, slowly turning over cells that arise via a relatively long-lived progenitor, the mucous neck cell, The differentiation of chief cells from neck cells does not involve cell division, and the neck cell has its own distinct pattern of gene expression and putative physiological function. Thus, the ontogeny of the normal chief cell lineage exemplifies transdifferentiation. Furthermore, under pathophysiogical loss of acid-secreting parietal cell, the chief cell lineage can itself trasndifferentiate into a mucous cell metaplasia designated Spasmolytic Polypeptide Expressing Metaplasia (SPEM). Especially in the presence of inflammation, this metaplastic lineage can regain proliferative capacity and, in humans may also further differentiate into intestinal metaplasia. The results indicate that gastric fundic lineages display remarkable plasticity in both physiological ontogeny and pathophysiological pre-neoplastic metaplasia.

Original language	English
Pages (from-to)	2759-2764
Number of pages	6
Journal	Experimental Cell Research
Volume	317
Issue number	19
DOIs	https://doi.org/10.1016/j.yexcr.2011.08.017
Publication status	Published - 2011 Nov 15

Bibliographical note

Funding Information:
Dr. Goldenring and Dr. Mills have both been supported by the AGA Funderburg Award in Gastric Biology Related to Cancer . Dr. Goldenring is also supported by grants from a Department of Veterans Affairs Merit Review Award, RO1 DK071590 from the National Institutes of Health , and by core resources of the Vanderbilt Digestive Disease Center , P30 DK058404 . Dr. Mills is also supported by DDC-115769 from the American Cancer Society and R01 DK-079798 and P30 DK052574 (the Washington University DDRCC), both from the National Institute of Diabetes and Digestive and Kidney Disease .

All Science Journal Classification (ASJC) codes

Cell Biology

Access to Document

10.1016/j.yexcr.2011.08.017

Cite this

@article{b67c57438531422cbd6e7f6bce03e5d8,

title = "The origin of pre-neoplastic metaplasia in the stomach: Chief cells emerge from the Mist",

abstract = "The digestive-enzyme secreting, gastric epithelial chief (zymogenic) cell is remarkable and underappreciated. Here, we discuss how all available evidence suggests that mature chief cells in the adult, mammalian stomach are postmitotic, slowly turning over cells that arise via a relatively long-lived progenitor, the mucous neck cell, The differentiation of chief cells from neck cells does not involve cell division, and the neck cell has its own distinct pattern of gene expression and putative physiological function. Thus, the ontogeny of the normal chief cell lineage exemplifies transdifferentiation. Furthermore, under pathophysiogical loss of acid-secreting parietal cell, the chief cell lineage can itself trasndifferentiate into a mucous cell metaplasia designated Spasmolytic Polypeptide Expressing Metaplasia (SPEM). Especially in the presence of inflammation, this metaplastic lineage can regain proliferative capacity and, in humans may also further differentiate into intestinal metaplasia. The results indicate that gastric fundic lineages display remarkable plasticity in both physiological ontogeny and pathophysiological pre-neoplastic metaplasia.",

author = "Goldenring, {James R.} and Nam, {Ki Taek} and Mills, {Jason C.}",

note = "Funding Information: Dr. Goldenring and Dr. Mills have both been supported by the AGA Funderburg Award in Gastric Biology Related to Cancer . Dr. Goldenring is also supported by grants from a Department of Veterans Affairs Merit Review Award, RO1 DK071590 from the National Institutes of Health , and by core resources of the Vanderbilt Digestive Disease Center , P30 DK058404 . Dr. Mills is also supported by DDC-115769 from the American Cancer Society and R01 DK-079798 and P30 DK052574 (the Washington University DDRCC), both from the National Institute of Diabetes and Digestive and Kidney Disease .",

year = "2011",

month = nov,

day = "15",

doi = "10.1016/j.yexcr.2011.08.017",

language = "English",

volume = "317",

pages = "2759--2764",

journal = "Experimental Cell Research",

issn = "0014-4827",

publisher = "Academic Press Inc.",

number = "19",

}

TY - JOUR

T1 - The origin of pre-neoplastic metaplasia in the stomach

T2 - Chief cells emerge from the Mist

AU - Goldenring, James R.

AU - Nam, Ki Taek

AU - Mills, Jason C.

N1 - Funding Information: Dr. Goldenring and Dr. Mills have both been supported by the AGA Funderburg Award in Gastric Biology Related to Cancer . Dr. Goldenring is also supported by grants from a Department of Veterans Affairs Merit Review Award, RO1 DK071590 from the National Institutes of Health , and by core resources of the Vanderbilt Digestive Disease Center , P30 DK058404 . Dr. Mills is also supported by DDC-115769 from the American Cancer Society and R01 DK-079798 and P30 DK052574 (the Washington University DDRCC), both from the National Institute of Diabetes and Digestive and Kidney Disease .

PY - 2011/11/15

Y1 - 2011/11/15

N2 - The digestive-enzyme secreting, gastric epithelial chief (zymogenic) cell is remarkable and underappreciated. Here, we discuss how all available evidence suggests that mature chief cells in the adult, mammalian stomach are postmitotic, slowly turning over cells that arise via a relatively long-lived progenitor, the mucous neck cell, The differentiation of chief cells from neck cells does not involve cell division, and the neck cell has its own distinct pattern of gene expression and putative physiological function. Thus, the ontogeny of the normal chief cell lineage exemplifies transdifferentiation. Furthermore, under pathophysiogical loss of acid-secreting parietal cell, the chief cell lineage can itself trasndifferentiate into a mucous cell metaplasia designated Spasmolytic Polypeptide Expressing Metaplasia (SPEM). Especially in the presence of inflammation, this metaplastic lineage can regain proliferative capacity and, in humans may also further differentiate into intestinal metaplasia. The results indicate that gastric fundic lineages display remarkable plasticity in both physiological ontogeny and pathophysiological pre-neoplastic metaplasia.

AB - The digestive-enzyme secreting, gastric epithelial chief (zymogenic) cell is remarkable and underappreciated. Here, we discuss how all available evidence suggests that mature chief cells in the adult, mammalian stomach are postmitotic, slowly turning over cells that arise via a relatively long-lived progenitor, the mucous neck cell, The differentiation of chief cells from neck cells does not involve cell division, and the neck cell has its own distinct pattern of gene expression and putative physiological function. Thus, the ontogeny of the normal chief cell lineage exemplifies transdifferentiation. Furthermore, under pathophysiogical loss of acid-secreting parietal cell, the chief cell lineage can itself trasndifferentiate into a mucous cell metaplasia designated Spasmolytic Polypeptide Expressing Metaplasia (SPEM). Especially in the presence of inflammation, this metaplastic lineage can regain proliferative capacity and, in humans may also further differentiate into intestinal metaplasia. The results indicate that gastric fundic lineages display remarkable plasticity in both physiological ontogeny and pathophysiological pre-neoplastic metaplasia.

UR - http://www.scopus.com/inward/record.url?scp=80455122910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80455122910&partnerID=8YFLogxK

U2 - 10.1016/j.yexcr.2011.08.017

DO - 10.1016/j.yexcr.2011.08.017

M3 - Review article

C2 - 21907708

AN - SCOPUS:80455122910

SN - 0014-4827

VL - 317

SP - 2759

EP - 2764

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 19

ER -

The origin of pre-neoplastic metaplasia in the stomach: Chief cells emerge from the Mist

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this