The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy

Hyuk Jae Chang, Jaehoon Chung, Byoung Joo Choi, Tae Young Choi, So Yeon Choi, Myeong Ho Yoon, Gyo Seung Hwang, Joon Han Shin, Seung Jea Tahk, Byung Il William Choi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor (sTNFR) I, II. TNF-α at CS (3.25±0.34 pg/mL) was higher than those of SA (1.81 ± 0.39 pg/mL) and IVC (1.88 ± 0.38 pg/mL, p<0.05). IL-6 at CS (18.3 ± 3.8 pg/mL) was higher than that of SA (5.8 ± 1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-α and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-α from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy.

Original languageEnglish
Pages (from-to)791-796
Number of pages6
JournalJournal of Korean medical science
Volume18
Issue number6
DOIs
Publication statusPublished - 2003 Dec

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Coronary Sinus
Dilated Cardiomyopathy
Inferior Vena Cava
Arteries
Cytokines
Tumor Necrosis Factor Receptors
Tumor Necrosis Factor-alpha
Cytokine Receptors
Interleukin-6
Blood Pressure
Cardiac Catheterization
Echocardiography
Myocardium
Heart Failure
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Chang, Hyuk Jae ; Chung, Jaehoon ; Choi, Byoung Joo ; Choi, Tae Young ; Choi, So Yeon ; Yoon, Myeong Ho ; Hwang, Gyo Seung ; Shin, Joon Han ; Tahk, Seung Jea ; Choi, Byung Il William. / The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy. In: Journal of Korean medical science. 2003 ; Vol. 18, No. 6. pp. 791-796.
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title = "The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy",
abstract = "Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor (sTNFR) I, II. TNF-α at CS (3.25±0.34 pg/mL) was higher than those of SA (1.81 ± 0.39 pg/mL) and IVC (1.88 ± 0.38 pg/mL, p<0.05). IL-6 at CS (18.3 ± 3.8 pg/mL) was higher than that of SA (5.8 ± 1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-α and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-α from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy.",
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Chang, HJ, Chung, J, Choi, BJ, Choi, TY, Choi, SY, Yoon, MH, Hwang, GS, Shin, JH, Tahk, SJ & Choi, BIW 2003, 'The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy', Journal of Korean medical science, vol. 18, no. 6, pp. 791-796. https://doi.org/10.3346/jkms.2003.18.6.791

The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy. / Chang, Hyuk Jae; Chung, Jaehoon; Choi, Byoung Joo; Choi, Tae Young; Choi, So Yeon; Yoon, Myeong Ho; Hwang, Gyo Seung; Shin, Joon Han; Tahk, Seung Jea; Choi, Byung Il William.

In: Journal of Korean medical science, Vol. 18, No. 6, 12.2003, p. 791-796.

Research output: Contribution to journalArticle

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T1 - The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy

AU - Chang, Hyuk Jae

AU - Chung, Jaehoon

AU - Choi, Byoung Joo

AU - Choi, Tae Young

AU - Choi, So Yeon

AU - Yoon, Myeong Ho

AU - Hwang, Gyo Seung

AU - Shin, Joon Han

AU - Tahk, Seung Jea

AU - Choi, Byung Il William

PY - 2003/12

Y1 - 2003/12

N2 - Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor (sTNFR) I, II. TNF-α at CS (3.25±0.34 pg/mL) was higher than those of SA (1.81 ± 0.39 pg/mL) and IVC (1.88 ± 0.38 pg/mL, p<0.05). IL-6 at CS (18.3 ± 3.8 pg/mL) was higher than that of SA (5.8 ± 1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-α and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-α from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy.

AB - Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor (sTNFR) I, II. TNF-α at CS (3.25±0.34 pg/mL) was higher than those of SA (1.81 ± 0.39 pg/mL) and IVC (1.88 ± 0.38 pg/mL, p<0.05). IL-6 at CS (18.3 ± 3.8 pg/mL) was higher than that of SA (5.8 ± 1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-α and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-α from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy.

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