The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy

Hyuk Jae Chang, Jaehoon Chung, Byoung Joo Choi, Tae Young Choi, So Yeon Choi, Myeong Ho Yoon, Gyo Seung Hwang, Joon Han Shin, Seung Jea Tahk, Byung Il William Choi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor (sTNFR) I, II. TNF-α at CS (3.25±0.34 pg/mL) was higher than those of SA (1.81 ± 0.39 pg/mL) and IVC (1.88 ± 0.38 pg/mL, p<0.05). IL-6 at CS (18.3 ± 3.8 pg/mL) was higher than that of SA (5.8 ± 1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-α and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-α from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy.

Original languageEnglish
Pages (from-to)791-796
Number of pages6
JournalJournal of Korean medical science
Volume18
Issue number6
DOIs
Publication statusPublished - 2003 Dec

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy'. Together they form a unique fingerprint.

Cite this