The overlooked cause of benign prostatic hyperplasia: prostatic urethral angulation

Kang Su Cho, Joohan Kim, Young Deuk Choi, Jang Hwan Kim, Sung Joon Hong

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Benign prostatic hyperplasia (BPH) is one of the most common problems faced by aging men and can be associated with bothersome lower urinary tract symptoms that affect quality of life by interfering with normal daily activities and sleep patterns. Despite the clinical importance of BPH, its pathogenesis is still poorly understood. Previously, our understanding of BPH was centered on bladder outlet obstruction being secondary to benign prostatic enlargement. However, prostate size itself is not correlated with the urine flow rate and symptomatology. The prostatic urethra is a bend tube and the increased prostatic urethral angulation shows a higher bladder neck on cystoscopic examination. Although some urologists suspected that the higher bladder neck might be a causal factor for BPH, the clinical significance of prostatic urethral angulation was previously underestimated. In this study, we propose a new hypothesis that prostatic urethral angulation is a causal factor for BPH. By applying the concept of fluid dynamics to the process of urination in the prostatic urethra, we show that the energy loss in this bending tube (the prostatic urethra) can occur during micturition and it increases proportionally to prostatic urethral angulation; this energy loss results in a decrease of the urine velocity and accordingly, the urine flow rate is inversely associated with prostatic urethral angulation. We also propose that BPH involves prostatic urethral angulation as well as the classical BPH triad of prostatic enlargement, bladder outlet obstruction, and symptomatology. Our hypothesis suggests that prostatic urethral angulation is an overlooked cause of bladder outlet obstruction and is a causal factor of BPH, and provides novel insight into the pathogenesis of BPH. Ultimately, the relationship between prostatic urethral angulation and urine flow rate, and other clinical factors including urodynamic parameters, the symptomatology, the response to treatment, and disease progression, need to be investigated in a clinical setting.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalMedical Hypotheses
Volume70
Issue number3
DOIs
Publication statusPublished - 2008 Feb 5

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Prostatic Hyperplasia
Urinary Bladder Neck Obstruction
Urethra
Urine
Urination
Urinary Bladder
Lower Urinary Tract Symptoms
Urodynamics
Hydrodynamics
Disease Progression
Prostate
Sleep
Quality of Life

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cho, Kang Su ; Kim, Joohan ; Choi, Young Deuk ; Kim, Jang Hwan ; Hong, Sung Joon. / The overlooked cause of benign prostatic hyperplasia : prostatic urethral angulation. In: Medical Hypotheses. 2008 ; Vol. 70, No. 3. pp. 532-535.
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The overlooked cause of benign prostatic hyperplasia : prostatic urethral angulation. / Cho, Kang Su; Kim, Joohan; Choi, Young Deuk; Kim, Jang Hwan; Hong, Sung Joon.

In: Medical Hypotheses, Vol. 70, No. 3, 05.02.2008, p. 532-535.

Research output: Contribution to journalArticle

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