Abstract
Background/Aim: Cortactin (CTTN) has been considered a promising molecular prognostic factor in various types of cancers. In this study, we aimed to investigate the role of CTTN in the pathogenesis of cutaneous squamous cell carcinoma (CSCC). Materials and Methods: CTTN and phospho-CTTN (p-CTTN) expression was determined in 10 healthy controls and 38 CSCC tissue samples by immunohistochemistry. The influence of CTTN on the biological behavior of CSCC cells was also investigated. Results: p-CTTN expression was significantly increased in CSCC than control samples. In contrast, no significant difference in CTTN expression was found between control and CSCC tissues. Moreover, a significant association was found between recurrence-free survival with p-CTTN expression, but not with CTTN expression. Furthermore, the proliferative, migratory, and invasive abilities of CSCC cells were significantly decreased by CTTN-siRNA transfection. Conclusion: CTTN phosphorylation is strongly associated with CSCC pathogenesis and may serve as a molecular biomarker of CSCC.
| Original language | English |
|---|---|
| Pages (from-to) | 393-400 |
| Number of pages | 8 |
| Journal | In Vivo |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2019 Mar |
Bibliographical note
Funding Information:This study was supported by a grant from the Jilin Provincial Health Department Project of china (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of china (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464).
Funding Information:
This study was supported by a grant from the Jilin Provincial Health Department Project of China (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of China (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464).
Publisher Copyright:
© 2019 International Institute of Anticancer Research. All Rights Reserved.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology
