The pathogenic effect of cortactin tyrosine phosphorylation in cutaneous squamous cell carcinoma

Lianhua Zhu; Eunae Cho; Guohua Zhao; M. I.Ryung Roh; Zhenlong Zheng

doi:10.21873/invivo.11486

The pathogenic effect of cortactin tyrosine phosphorylation in cutaneous squamous cell carcinoma

Lianhua Zhu, Eunae Cho, Guohua Zhao, M. I.Ryung Roh, Zhenlong Zheng

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background/Aim: Cortactin (CTTN) has been considered a promising molecular prognostic factor in various types of cancers. In this study, we aimed to investigate the role of CTTN in the pathogenesis of cutaneous squamous cell carcinoma (CSCC). Materials and Methods: CTTN and phospho-CTTN (p-CTTN) expression was determined in 10 healthy controls and 38 CSCC tissue samples by immunohistochemistry. The influence of CTTN on the biological behavior of CSCC cells was also investigated. Results: p-CTTN expression was significantly increased in CSCC than control samples. In contrast, no significant difference in CTTN expression was found between control and CSCC tissues. Moreover, a significant association was found between recurrence-free survival with p-CTTN expression, but not with CTTN expression. Furthermore, the proliferative, migratory, and invasive abilities of CSCC cells were significantly decreased by CTTN-siRNA transfection. Conclusion: CTTN phosphorylation is strongly associated with CSCC pathogenesis and may serve as a molecular biomarker of CSCC.

Original language	English
Pages (from-to)	393-400
Number of pages	8
Journal	In Vivo
Volume	33
Issue number	2
DOIs	https://doi.org/10.21873/invivo.11486
Publication status	Published - 2019 Mar

Bibliographical note

Funding Information:
This study was supported by a grant from the Jilin Provincial Health Department Project of china (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of china (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464).

Funding Information:
This study was supported by a grant from the Jilin Provincial Health Department Project of China (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of China (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464).

Publisher Copyright:
© 2019 International Institute of Anticancer Research. All Rights Reserved.

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology

UN SDGs

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@article{e2ae76b2fa01476a888b657ef910c1be,

title = "The pathogenic effect of cortactin tyrosine phosphorylation in cutaneous squamous cell carcinoma",

abstract = "Background/Aim: Cortactin (CTTN) has been considered a promising molecular prognostic factor in various types of cancers. In this study, we aimed to investigate the role of CTTN in the pathogenesis of cutaneous squamous cell carcinoma (CSCC). Materials and Methods: CTTN and phospho-CTTN (p-CTTN) expression was determined in 10 healthy controls and 38 CSCC tissue samples by immunohistochemistry. The influence of CTTN on the biological behavior of CSCC cells was also investigated. Results: p-CTTN expression was significantly increased in CSCC than control samples. In contrast, no significant difference in CTTN expression was found between control and CSCC tissues. Moreover, a significant association was found between recurrence-free survival with p-CTTN expression, but not with CTTN expression. Furthermore, the proliferative, migratory, and invasive abilities of CSCC cells were significantly decreased by CTTN-siRNA transfection. Conclusion: CTTN phosphorylation is strongly associated with CSCC pathogenesis and may serve as a molecular biomarker of CSCC.",

author = "Lianhua Zhu and Eunae Cho and Guohua Zhao and Roh, {M. I.Ryung} and Zhenlong Zheng",

note = "Funding Information: This study was supported by a grant from the Jilin Provincial Health Department Project of china (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of china (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464). Funding Information: This study was supported by a grant from the Jilin Provincial Health Department Project of China (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of China (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464). Publisher Copyright: {\textcopyright} 2019 International Institute of Anticancer Research. All Rights Reserved.",

year = "2019",

month = mar,

doi = "10.21873/invivo.11486",

language = "English",

volume = "33",

pages = "393--400",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - The pathogenic effect of cortactin tyrosine phosphorylation in cutaneous squamous cell carcinoma

AU - Zhu, Lianhua

AU - Cho, Eunae

AU - Zhao, Guohua

AU - Roh, M. I.Ryung

AU - Zheng, Zhenlong

N1 - Funding Information: This study was supported by a grant from the Jilin Provincial Health Department Project of china (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of china (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464). Funding Information: This study was supported by a grant from the Jilin Provincial Health Department Project of China (2014Z094), Jilin Provincial Department of education “thirteen five” science and technology project of China (JJKH20170467KJ), a faculty research grant of Yonsei University College of Medicine of korea (6-2017-0078), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B1012464). Publisher Copyright: © 2019 International Institute of Anticancer Research. All Rights Reserved.

PY - 2019/3

Y1 - 2019/3

N2 - Background/Aim: Cortactin (CTTN) has been considered a promising molecular prognostic factor in various types of cancers. In this study, we aimed to investigate the role of CTTN in the pathogenesis of cutaneous squamous cell carcinoma (CSCC). Materials and Methods: CTTN and phospho-CTTN (p-CTTN) expression was determined in 10 healthy controls and 38 CSCC tissue samples by immunohistochemistry. The influence of CTTN on the biological behavior of CSCC cells was also investigated. Results: p-CTTN expression was significantly increased in CSCC than control samples. In contrast, no significant difference in CTTN expression was found between control and CSCC tissues. Moreover, a significant association was found between recurrence-free survival with p-CTTN expression, but not with CTTN expression. Furthermore, the proliferative, migratory, and invasive abilities of CSCC cells were significantly decreased by CTTN-siRNA transfection. Conclusion: CTTN phosphorylation is strongly associated with CSCC pathogenesis and may serve as a molecular biomarker of CSCC.

AB - Background/Aim: Cortactin (CTTN) has been considered a promising molecular prognostic factor in various types of cancers. In this study, we aimed to investigate the role of CTTN in the pathogenesis of cutaneous squamous cell carcinoma (CSCC). Materials and Methods: CTTN and phospho-CTTN (p-CTTN) expression was determined in 10 healthy controls and 38 CSCC tissue samples by immunohistochemistry. The influence of CTTN on the biological behavior of CSCC cells was also investigated. Results: p-CTTN expression was significantly increased in CSCC than control samples. In contrast, no significant difference in CTTN expression was found between control and CSCC tissues. Moreover, a significant association was found between recurrence-free survival with p-CTTN expression, but not with CTTN expression. Furthermore, the proliferative, migratory, and invasive abilities of CSCC cells were significantly decreased by CTTN-siRNA transfection. Conclusion: CTTN phosphorylation is strongly associated with CSCC pathogenesis and may serve as a molecular biomarker of CSCC.

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JF - In Vivo

SN - 0258-851X

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The pathogenic effect of cortactin tyrosine phosphorylation in cutaneous squamous cell carcinoma

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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