The photoprotective effect of S-methylmethionine sulfonium in skin

Won Serk Kim, Hyun Min Seo, Wang Kyun Kim, Joon Seok Choi, Ikyon Kim, Jong Hyuk Sung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB.

Original languageEnglish
Pages (from-to)17088-17100
Number of pages13
JournalInternational journal of molecular sciences
Volume16
Issue number8
DOIs
Publication statusPublished - 2015 Jul 28

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Vitamin U
fibroblasts
Fibroblasts
Skin
cells
Irradiation
Keratinocytes
viability
irradiation
Stem Cells
wound healing
phosphorylation
Phosphorylation
Cosmetics
apoptosis
Cell death
collagens
Erythema
Collagen
inhibitors

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Kim, Won Serk ; Seo, Hyun Min ; Kim, Wang Kyun ; Choi, Joon Seok ; Kim, Ikyon ; Sung, Jong Hyuk. / The photoprotective effect of S-methylmethionine sulfonium in skin. In: International journal of molecular sciences. 2015 ; Vol. 16, No. 8. pp. 17088-17100.
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abstract = "S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5{\%} and 10{\%} SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB.",
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The photoprotective effect of S-methylmethionine sulfonium in skin. / Kim, Won Serk; Seo, Hyun Min; Kim, Wang Kyun; Choi, Joon Seok; Kim, Ikyon; Sung, Jong Hyuk.

In: International journal of molecular sciences, Vol. 16, No. 8, 28.07.2015, p. 17088-17100.

Research output: Contribution to journalArticle

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