The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy

P. H. Lee; G. Lee; H. J. Park; O. Y. Bang; I. S. Joo; K. Huh

doi:10.1007/s00702-005-0427-9

The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy

P. H. Lee, G. Lee, H. J. Park, O. Y. Bang, I. S. Joo, K. Huh

Department of Neurology

Research output: Contribution to journal › Article › peer-review

153 Citations (Scopus)

Abstract

α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.

Original language	English
Pages (from-to)	1435-1439
Number of pages	5
Journal	Journal of Neural Transmission
Volume	113
Issue number	10
DOIs	https://doi.org/10.1007/s00702-005-0427-9
Publication status	Published - 2006 Oct

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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abstract = "α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.",

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