The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy

P. H. Lee, G. Lee, H. J. Park, O. Y. Bang, I. S. Joo, K. Huh

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.

Original languageEnglish
Pages (from-to)1435-1439
Number of pages5
JournalJournal of Neural Transmission
Volume113
Issue number10
DOIs
Publication statusPublished - 2006 Oct 1

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Synucleins
Multiple System Atrophy
alpha-Synuclein
Parkinson Disease
Lewy Bodies
Proteins

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Lee, P. H. ; Lee, G. ; Park, H. J. ; Bang, O. Y. ; Joo, I. S. ; Huh, K. / The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. In: Journal of Neural Transmission. 2006 ; Vol. 113, No. 10. pp. 1435-1439.
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The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. / Lee, P. H.; Lee, G.; Park, H. J.; Bang, O. Y.; Joo, I. S.; Huh, K.

In: Journal of Neural Transmission, Vol. 113, No. 10, 01.10.2006, p. 1435-1439.

Research output: Contribution to journalArticle

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