Abstract
α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.
| Original language | English |
|---|---|
| Pages (from-to) | 1435-1439 |
| Number of pages | 5 |
| Journal | Journal of Neural Transmission |
| Volume | 113 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2006 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
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The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy. / Lee, P. H.; Lee, G.; Park, H. J.; Bang, O. Y.; Joo, I. S.; Huh, K.
In: Journal of Neural Transmission, Vol. 113, No. 10, 01.10.2006, p. 1435-1439.Research output: Contribution to journal › Article
TY - JOUR
T1 - The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy
AU - Lee, P. H.
AU - Lee, G.
AU - Park, H. J.
AU - Bang, O. Y.
AU - Joo, I. S.
AU - Huh, K.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.
AB - α-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma α-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The α-synuclein level was significantly elevated in patients with PD (79.9 ± 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 ± 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 ± 3.9 pg/ml). The α-synuclein level was higher in patients with PD than in those with MSA (79.9 ± 4.0 vs 78.1 ± 3.5, p = 0.016). Our study demonstrated that the α-synuclein level in plasma is elevated in patients with PD and MSA.
UR - http://www.scopus.com/inward/record.url?scp=33748932543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748932543&partnerID=8YFLogxK
U2 - 10.1007/s00702-005-0427-9
DO - 10.1007/s00702-005-0427-9
M3 - Article
C2 - 16465458
AN - SCOPUS:33748932543
VL - 113
SP - 1435
EP - 1439
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 10
ER -