The pleiotropy of telomerase against cell death

Young Hoon Sung, Yoon Sik Choi, Cheolho Cheong, Han Woong Lee

Research output: Contribution to journalShort survey

36 Citations (Scopus)

Abstract

The end of eukaryotic genomic DNA is capped by a specialized structure called as "telomere", which consists of the repetitive array of nucleotide sequence, TTAGGG, in humans and mice, and a variety of binding proteins. Telomerase is a ribonucleoprotein (RNP) complex responsible for the elongation of telomeres to maintain the genomic integrity, and is composed of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC), and their associated factors regulating the catalytic activity of telomerase. Although it is now apparent that telomerase protects cells from apoptosis via the maintenance of genomic integrity by stabilizing telomeres, our understanding for the physiological role of telomerase is yet far from completion, and emerging evidence suggests that telomerase has additional extratelomeric roles in mediating cell survival and anti-apoptotic functions against various cytotoxic stresses. Here we summarize and discuss how telomerase and telomeres are involved in mediating cellular protection against apoptosis.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalMolecules and Cells
Volume19
Issue number3
Publication statusPublished - 2005 Dec 1

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sung, Y. H., Choi, Y. S., Cheong, C., & Lee, H. W. (2005). The pleiotropy of telomerase against cell death. Molecules and Cells, 19(3), 303-309.