Abstract
Introduction: Beclin 1 plays a crucial role in autophagy via the Beclin 1 interactome, and is involved in various biological processes such as protein sorting, chemokinesis, and cell death. Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.Areas covered: Beclin 1 plays a key biologic function on cell homeostasis and affects tumorigenesis. In this review, detailing up-to-date knowledge on the tumorigenic role of Beclin 1, its implication in breast cancer, and its utility as a breast cancer-specific drug target is discussed.Expert opinion: Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype.
| Original language | English |
|---|---|
| Pages (from-to) | 167-178 |
| Number of pages | 12 |
| Journal | Expert Opinion on Therapeutic Targets |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2016 Feb 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Clinical Biochemistry
Cite this
}
The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer. / Jung, Yoon Yang; Lee, Yu Kyung; Koo, JaSeung.
In: Expert Opinion on Therapeutic Targets, Vol. 20, No. 2, 01.02.2016, p. 167-178.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer
AU - Jung, Yoon Yang
AU - Lee, Yu Kyung
AU - Koo, JaSeung
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Introduction: Beclin 1 plays a crucial role in autophagy via the Beclin 1 interactome, and is involved in various biological processes such as protein sorting, chemokinesis, and cell death. Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.Areas covered: Beclin 1 plays a key biologic function on cell homeostasis and affects tumorigenesis. In this review, detailing up-to-date knowledge on the tumorigenic role of Beclin 1, its implication in breast cancer, and its utility as a breast cancer-specific drug target is discussed.Expert opinion: Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype.
AB - Introduction: Beclin 1 plays a crucial role in autophagy via the Beclin 1 interactome, and is involved in various biological processes such as protein sorting, chemokinesis, and cell death. Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.Areas covered: Beclin 1 plays a key biologic function on cell homeostasis and affects tumorigenesis. In this review, detailing up-to-date knowledge on the tumorigenic role of Beclin 1, its implication in breast cancer, and its utility as a breast cancer-specific drug target is discussed.Expert opinion: Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype.
UR - http://www.scopus.com/inward/record.url?scp=84957936470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957936470&partnerID=8YFLogxK
U2 - 10.1517/14728222.2016.1085971
DO - 10.1517/14728222.2016.1085971
M3 - Review article
C2 - 26357854
AN - SCOPUS:84957936470
VL - 20
SP - 167
EP - 178
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
SN - 1472-8222
IS - 2
ER -