The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer

Yoon Yang Jung, Yu Kyung Lee, JaSeung Koo

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Introduction: Beclin 1 plays a crucial role in autophagy via the Beclin 1 interactome, and is involved in various biological processes such as protein sorting, chemokinesis, and cell death. Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.Areas covered: Beclin 1 plays a key biologic function on cell homeostasis and affects tumorigenesis. In this review, detailing up-to-date knowledge on the tumorigenic role of Beclin 1, its implication in breast cancer, and its utility as a breast cancer-specific drug target is discussed.Expert opinion: Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype.

Original languageEnglish
Pages (from-to)167-178
Number of pages12
JournalExpert Opinion on Therapeutic Targets
Volume20
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Fingerprint

Tumors
Breast Neoplasms
Cell death
Sorting
Pharmaceutical Preparations
Therapeutics
Cells
Beclin-1
Proteins
Biological Phenomena
Neoplasms
Autophagy
Expert Testimony
Protein Transport
Carcinogenesis
Homeostasis
Cell Death

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

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abstract = "Introduction: Beclin 1 plays a crucial role in autophagy via the Beclin 1 interactome, and is involved in various biological processes such as protein sorting, chemokinesis, and cell death. Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.Areas covered: Beclin 1 plays a key biologic function on cell homeostasis and affects tumorigenesis. In this review, detailing up-to-date knowledge on the tumorigenic role of Beclin 1, its implication in breast cancer, and its utility as a breast cancer-specific drug target is discussed.Expert opinion: Because Beclin 1 is expressed in breast cancer cells, Beclin 1 could be a unique, effective drug target for the prevention and treatment of breast cancer. However, the expression of Beclin 1 varies according to cancer molecular subtypes, and Beclin 1 is involved in both breast cancer suppression and tumor progression; therefore, the decision of using a Beclin 1 inducer or inhibitor should be made based on breast cancer stage and subtype.",
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The potential of Beclin 1 as a therapeutic target for the treatment of breast cancer. / Jung, Yoon Yang; Lee, Yu Kyung; Koo, JaSeung.

In: Expert Opinion on Therapeutic Targets, Vol. 20, No. 2, 01.02.2016, p. 167-178.

Research output: Contribution to journalReview article

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