The prevalence and clinical significance of perinuclear anti-neutrophil cytoplasmic antibody in Korean patients with ulcerative colitis

Jin Ha Lee, JaeHee Cheon, Eun Soo Kim, Moon Jae Chung, Wonseok Kang, Duk Hwan Kim, You Jung Ha, Jae Jun Park, Tae Il Kim, Won Ho Kim

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7 Citations (Scopus)

Abstract

Perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is a serological marker associated with various immune-mediated diseases whose clinical significance and possible diagnostic roles in ulcerative colitis (UC) are still unclear. We aimed to evaluate the prevalence of pANCA expression and its association with clinical findings and disease course in Korean patients with UC. This study included 484 patients with UC who were diagnosed and treated between 1990 and 2006 at Severance Hospital, Yonsei University, Seoul, Korea, and were followed for at least 1 year. Clinical findings at diagnosis, disease extent, treatment modalities used, and cumulative relapse rates were analyzed and compared to pANCA expression. Of the 484 patients, 405 (83.7%) were evaluated for pANCA and were eligible for analysis. The overall pANCA prevalence was 22.1%, with a female preponderance (male, 21.5%; female, 31.6%; P<0.05). Proctitis was more common in pANCAnegative patients (pANCA-negative, 37.6%; pANCA-positive, 25.2%, P<0.05). UC activity index and cumulative relapse rates were higher in pANCA-positive patients. However, there were no significant differences in the cumulative probability of steroid and immunosuppressant use and operation rate between the two groups. The prevalence of pANCA expression in Korean patients with UC was relatively low compared to that in Western countries. Although UC patients with pANCA expression had more severe clinical findings at diagnosis and higher cumulative relapse rates in our study, further prospective studies are warranted to clarify whether pANCA positivity influences the initial clinical presentation or disease aggressiveness.

Original languageEnglish
Pages (from-to)1406-1412
Number of pages7
JournalDigestive diseases and sciences
Volume55
Issue number5
DOIs
Publication statusPublished - 2010 May 1

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Antineutrophil Cytoplasmic Antibodies
Ulcerative Colitis
Recurrence
Proctitis
Immune System Diseases
Immunosuppressive Agents
Korea
Steroids
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Lee, Jin Ha ; Cheon, JaeHee ; Kim, Eun Soo ; Chung, Moon Jae ; Kang, Wonseok ; Kim, Duk Hwan ; Ha, You Jung ; Park, Jae Jun ; Kim, Tae Il ; Kim, Won Ho. / The prevalence and clinical significance of perinuclear anti-neutrophil cytoplasmic antibody in Korean patients with ulcerative colitis. In: Digestive diseases and sciences. 2010 ; Vol. 55, No. 5. pp. 1406-1412.
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abstract = "Perinuclear anti-neutrophil cytoplasmic antibody (pANCA) is a serological marker associated with various immune-mediated diseases whose clinical significance and possible diagnostic roles in ulcerative colitis (UC) are still unclear. We aimed to evaluate the prevalence of pANCA expression and its association with clinical findings and disease course in Korean patients with UC. This study included 484 patients with UC who were diagnosed and treated between 1990 and 2006 at Severance Hospital, Yonsei University, Seoul, Korea, and were followed for at least 1 year. Clinical findings at diagnosis, disease extent, treatment modalities used, and cumulative relapse rates were analyzed and compared to pANCA expression. Of the 484 patients, 405 (83.7{\%}) were evaluated for pANCA and were eligible for analysis. The overall pANCA prevalence was 22.1{\%}, with a female preponderance (male, 21.5{\%}; female, 31.6{\%}; P<0.05). Proctitis was more common in pANCAnegative patients (pANCA-negative, 37.6{\%}; pANCA-positive, 25.2{\%}, P<0.05). UC activity index and cumulative relapse rates were higher in pANCA-positive patients. However, there were no significant differences in the cumulative probability of steroid and immunosuppressant use and operation rate between the two groups. The prevalence of pANCA expression in Korean patients with UC was relatively low compared to that in Western countries. Although UC patients with pANCA expression had more severe clinical findings at diagnosis and higher cumulative relapse rates in our study, further prospective studies are warranted to clarify whether pANCA positivity influences the initial clinical presentation or disease aggressiveness.",
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The prevalence and clinical significance of perinuclear anti-neutrophil cytoplasmic antibody in Korean patients with ulcerative colitis. / Lee, Jin Ha; Cheon, JaeHee; Kim, Eun Soo; Chung, Moon Jae; Kang, Wonseok; Kim, Duk Hwan; Ha, You Jung; Park, Jae Jun; Kim, Tae Il; Kim, Won Ho.

In: Digestive diseases and sciences, Vol. 55, No. 5, 01.05.2010, p. 1406-1412.

Research output: Contribution to journalArticle

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AU - Cheon, JaeHee

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AU - Kang, Wonseok

AU - Kim, Duk Hwan

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AU - Kim, Won Ho

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