The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection:a prospective multicenter study

You Sun Kim, Young Ho Kim, Joo Sung Kim, JaeHee Cheon, Byong Duk Ye, J. Sung Ae Jung, Young Sook Park, Chang Hwan Choi, Byung Ik Jang, Dong Soo Han, Suk Kyun Yang, Won Ho Kim

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Abstract

Background: It remains controversial whether or not cytomegalovirus infection in patients with active ulcerative colitis reflects a nonpathogenic colonization or a pathogenic disease warranting antiviral therapy. Goals: The aim of this study was to determine the prevalence of cytomegalovirus infection in patients with active ulcerative colitis and the therapeutic efficacy of ganciclovir against cytomegalovirus infection in patients with steroid-refractory ulcerative colitis. Study: A prospective, multicenter study was conducted in 72 patients with moderate-to-severe ulcerative colitis who were treated with intravenous steroids. The presence of cytomegalovirus was evaluated serologically and histopathologic examination, including immunohistochemical staining. In patients with steroid-refractory ulcerative colitis, cytomegalovirus infections were treated with intravenous ganciclovir. In patients with steroid-responsive ulcerative colitis, steroid therapy was continued irrespective of cytomegalovirus infection. Results: The evidence of cytomegalovirus infection was found in 31 patients (43%) with moderate-to-severe active ulcerative colitis. In patients with steroid-refractory ulcerative colitis, the cytomegalovirus infection rate increased to 67% (14 of 21). No significant clinical and endoscopic differences existed between patients with and without a cytomegalovirus infection; however, the amount of steroids used during the flare-up period was significantly higher in patients with a cytomegalovirus infection (P=0.013). Eleven of 14 patients (79%) with steroid-refractory ulcerative colitis and a cytomegalovirus infection improved with ganciclovir treatment. Cytomegalovirus infections in the steroid-responsive group (17 of 31) did not require ganciclovir therapy. Conclusions: Cytomegalovirus infections are frequently observed in patients with moderate-to-severe ulcerative colitis, especially steroid-refractory ulcerative colitis. Ganciclovir was effective in patients with steroid-refractory ulcerative colitis who had a cytomegalovirus infection.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume46
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Ganciclovir
Cytomegalovirus Infections
Ulcerative Colitis
Multicenter Studies
Steroids
Prospective Studies
Therapeutics
Cytomegalovirus
Antiviral Agents

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kim, You Sun ; Kim, Young Ho ; Kim, Joo Sung ; Cheon, JaeHee ; Ye, Byong Duk ; Jung, J. Sung Ae ; Park, Young Sook ; Choi, Chang Hwan ; Jang, Byung Ik ; Han, Dong Soo ; Yang, Suk Kyun ; Kim, Won Ho. / The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection:a prospective multicenter study. In: Journal of Clinical Gastroenterology. 2012 ; Vol. 46, No. 1. pp. 51-56.
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abstract = "Background: It remains controversial whether or not cytomegalovirus infection in patients with active ulcerative colitis reflects a nonpathogenic colonization or a pathogenic disease warranting antiviral therapy. Goals: The aim of this study was to determine the prevalence of cytomegalovirus infection in patients with active ulcerative colitis and the therapeutic efficacy of ganciclovir against cytomegalovirus infection in patients with steroid-refractory ulcerative colitis. Study: A prospective, multicenter study was conducted in 72 patients with moderate-to-severe ulcerative colitis who were treated with intravenous steroids. The presence of cytomegalovirus was evaluated serologically and histopathologic examination, including immunohistochemical staining. In patients with steroid-refractory ulcerative colitis, cytomegalovirus infections were treated with intravenous ganciclovir. In patients with steroid-responsive ulcerative colitis, steroid therapy was continued irrespective of cytomegalovirus infection. Results: The evidence of cytomegalovirus infection was found in 31 patients (43{\%}) with moderate-to-severe active ulcerative colitis. In patients with steroid-refractory ulcerative colitis, the cytomegalovirus infection rate increased to 67{\%} (14 of 21). No significant clinical and endoscopic differences existed between patients with and without a cytomegalovirus infection; however, the amount of steroids used during the flare-up period was significantly higher in patients with a cytomegalovirus infection (P=0.013). Eleven of 14 patients (79{\%}) with steroid-refractory ulcerative colitis and a cytomegalovirus infection improved with ganciclovir treatment. Cytomegalovirus infections in the steroid-responsive group (17 of 31) did not require ganciclovir therapy. Conclusions: Cytomegalovirus infections are frequently observed in patients with moderate-to-severe ulcerative colitis, especially steroid-refractory ulcerative colitis. Ganciclovir was effective in patients with steroid-refractory ulcerative colitis who had a cytomegalovirus infection.",
author = "Kim, {You Sun} and Kim, {Young Ho} and Kim, {Joo Sung} and JaeHee Cheon and Ye, {Byong Duk} and Jung, {J. Sung Ae} and Park, {Young Sook} and Choi, {Chang Hwan} and Jang, {Byung Ik} and Han, {Dong Soo} and Yang, {Suk Kyun} and Kim, {Won Ho}",
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The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection:a prospective multicenter study. / Kim, You Sun; Kim, Young Ho; Kim, Joo Sung; Cheon, JaeHee; Ye, Byong Duk; Jung, J. Sung Ae; Park, Young Sook; Choi, Chang Hwan; Jang, Byung Ik; Han, Dong Soo; Yang, Suk Kyun; Kim, Won Ho.

In: Journal of Clinical Gastroenterology, Vol. 46, No. 1, 01.01.2012, p. 51-56.

Research output: Contribution to journalArticle

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T1 - The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection:a prospective multicenter study

AU - Kim, You Sun

AU - Kim, Young Ho

AU - Kim, Joo Sung

AU - Cheon, JaeHee

AU - Ye, Byong Duk

AU - Jung, J. Sung Ae

AU - Park, Young Sook

AU - Choi, Chang Hwan

AU - Jang, Byung Ik

AU - Han, Dong Soo

AU - Yang, Suk Kyun

AU - Kim, Won Ho

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: It remains controversial whether or not cytomegalovirus infection in patients with active ulcerative colitis reflects a nonpathogenic colonization or a pathogenic disease warranting antiviral therapy. Goals: The aim of this study was to determine the prevalence of cytomegalovirus infection in patients with active ulcerative colitis and the therapeutic efficacy of ganciclovir against cytomegalovirus infection in patients with steroid-refractory ulcerative colitis. Study: A prospective, multicenter study was conducted in 72 patients with moderate-to-severe ulcerative colitis who were treated with intravenous steroids. The presence of cytomegalovirus was evaluated serologically and histopathologic examination, including immunohistochemical staining. In patients with steroid-refractory ulcerative colitis, cytomegalovirus infections were treated with intravenous ganciclovir. In patients with steroid-responsive ulcerative colitis, steroid therapy was continued irrespective of cytomegalovirus infection. Results: The evidence of cytomegalovirus infection was found in 31 patients (43%) with moderate-to-severe active ulcerative colitis. In patients with steroid-refractory ulcerative colitis, the cytomegalovirus infection rate increased to 67% (14 of 21). No significant clinical and endoscopic differences existed between patients with and without a cytomegalovirus infection; however, the amount of steroids used during the flare-up period was significantly higher in patients with a cytomegalovirus infection (P=0.013). Eleven of 14 patients (79%) with steroid-refractory ulcerative colitis and a cytomegalovirus infection improved with ganciclovir treatment. Cytomegalovirus infections in the steroid-responsive group (17 of 31) did not require ganciclovir therapy. Conclusions: Cytomegalovirus infections are frequently observed in patients with moderate-to-severe ulcerative colitis, especially steroid-refractory ulcerative colitis. Ganciclovir was effective in patients with steroid-refractory ulcerative colitis who had a cytomegalovirus infection.

AB - Background: It remains controversial whether or not cytomegalovirus infection in patients with active ulcerative colitis reflects a nonpathogenic colonization or a pathogenic disease warranting antiviral therapy. Goals: The aim of this study was to determine the prevalence of cytomegalovirus infection in patients with active ulcerative colitis and the therapeutic efficacy of ganciclovir against cytomegalovirus infection in patients with steroid-refractory ulcerative colitis. Study: A prospective, multicenter study was conducted in 72 patients with moderate-to-severe ulcerative colitis who were treated with intravenous steroids. The presence of cytomegalovirus was evaluated serologically and histopathologic examination, including immunohistochemical staining. In patients with steroid-refractory ulcerative colitis, cytomegalovirus infections were treated with intravenous ganciclovir. In patients with steroid-responsive ulcerative colitis, steroid therapy was continued irrespective of cytomegalovirus infection. Results: The evidence of cytomegalovirus infection was found in 31 patients (43%) with moderate-to-severe active ulcerative colitis. In patients with steroid-refractory ulcerative colitis, the cytomegalovirus infection rate increased to 67% (14 of 21). No significant clinical and endoscopic differences existed between patients with and without a cytomegalovirus infection; however, the amount of steroids used during the flare-up period was significantly higher in patients with a cytomegalovirus infection (P=0.013). Eleven of 14 patients (79%) with steroid-refractory ulcerative colitis and a cytomegalovirus infection improved with ganciclovir treatment. Cytomegalovirus infections in the steroid-responsive group (17 of 31) did not require ganciclovir therapy. Conclusions: Cytomegalovirus infections are frequently observed in patients with moderate-to-severe ulcerative colitis, especially steroid-refractory ulcerative colitis. Ganciclovir was effective in patients with steroid-refractory ulcerative colitis who had a cytomegalovirus infection.

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