The prevalence and risk factors of renal insufficiency among Korean HIV-infected patients: The Korea HIV/AIDS cohort study

The Korea HIV/AIDS Cohort Study

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Renal disease is one of the leading causes of morbidity and mortality among people infected with human immunodeficiency virus (HIV). However, there are very few published studies about renal insufficiency in HIV-infected persons in Asia, especially in South Korea. Materials and Methods: A cross-sectional study was performed to investigate the prevalence and risk factors of renal insufficiency, defined as < 60 mL/min/1.73 m 2 , in subjects in the Korea HIV/AIDS Cohort Study enrolled from 19 institutions between December 2006 and July 2013. Data at entry into the cohort were analyzed. Results: Of 454 enrolled subjects, 24 (5.3%) showed renal insufficiency at entry into the cohort. The mean age of patients in the renal insufficiency group was 5.28 years and the majority were male subjects (91.7%). All the patients were receiving antiretroviral agents, mostly protease inhibitor-based regimens (76.4%), for an average of 19 months. In univariate analysis, older age (P = 0.002), diabetes mellitus (DM) (P = 0.0002), unknown route of transmission (P = 0.007), and taking indinavir (P = 0.0022) were associated with renal insufficiency. In multivariable analysis, older age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.03-1.12, P = 0.002], DM [OR 3.03, 95% CI 1.17-7.82, P = 0.022], unknown route of transmission [OR 6.15, 95% CI 1.77-21.33, P = 0.004], and taking indinavir [OR 3.07, 95% CI 1.17-8.05, P = 0.023] were independent risk factors of renal insufficiency. treatConclusion: The prevalence of renal insufficiency in HIV-infected subjects in this study was relatively low, similar to that in other countries. Aging, DM, and taking indinavir were significantly associated with decreased glomerular filtration rate. Furthermore, unknown route of transmission was an independent risk factor, which was interpreted as a reflection of patient compliance. Further studies on the incidence and risk factors of renal insufficiency during HIV infection using follow-up cohort data are necessary.

Original languageEnglish
Pages (from-to)194-205
Number of pages12
JournalInfection and Chemotherapy
Volume49
Issue number3
DOIs
Publication statusPublished - 2017 Jan 1

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Korea
Renal Insufficiency
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Indinavir
Odds Ratio
Confidence Intervals
Diabetes Mellitus
Anti-Retroviral Agents
Republic of Korea
Virus Diseases
Patient Compliance
Protease Inhibitors
Glomerular Filtration Rate
Cross-Sectional Studies
Morbidity
Kidney
Mortality

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

@article{4f5609e8a32143cab90a1f1dc1c82c16,
title = "The prevalence and risk factors of renal insufficiency among Korean HIV-infected patients: The Korea HIV/AIDS cohort study",
abstract = "Background: Renal disease is one of the leading causes of morbidity and mortality among people infected with human immunodeficiency virus (HIV). However, there are very few published studies about renal insufficiency in HIV-infected persons in Asia, especially in South Korea. Materials and Methods: A cross-sectional study was performed to investigate the prevalence and risk factors of renal insufficiency, defined as < 60 mL/min/1.73 m 2 , in subjects in the Korea HIV/AIDS Cohort Study enrolled from 19 institutions between December 2006 and July 2013. Data at entry into the cohort were analyzed. Results: Of 454 enrolled subjects, 24 (5.3{\%}) showed renal insufficiency at entry into the cohort. The mean age of patients in the renal insufficiency group was 5.28 years and the majority were male subjects (91.7{\%}). All the patients were receiving antiretroviral agents, mostly protease inhibitor-based regimens (76.4{\%}), for an average of 19 months. In univariate analysis, older age (P = 0.002), diabetes mellitus (DM) (P = 0.0002), unknown route of transmission (P = 0.007), and taking indinavir (P = 0.0022) were associated with renal insufficiency. In multivariable analysis, older age [odds ratio (OR) 1.07, 95{\%} confidence interval (CI) 1.03-1.12, P = 0.002], DM [OR 3.03, 95{\%} CI 1.17-7.82, P = 0.022], unknown route of transmission [OR 6.15, 95{\%} CI 1.77-21.33, P = 0.004], and taking indinavir [OR 3.07, 95{\%} CI 1.17-8.05, P = 0.023] were independent risk factors of renal insufficiency. treatConclusion: The prevalence of renal insufficiency in HIV-infected subjects in this study was relatively low, similar to that in other countries. Aging, DM, and taking indinavir were significantly associated with decreased glomerular filtration rate. Furthermore, unknown route of transmission was an independent risk factor, which was interpreted as a reflection of patient compliance. Further studies on the incidence and risk factors of renal insufficiency during HIV infection using follow-up cohort data are necessary.",
author = "{The Korea HIV/AIDS Cohort Study} and Kim, {Eun Jin} and Ahn, {Jin Young} and Kim, {Youn Jeong} and Wie, {Seong Heon} and Park, {Dae Won} and Song, {Joon Young} and Choi, {Hee Jung} and Chang, {Hyun Ha} and Choi, {Bo Youl} and Yunsu Choi and Choi, {Ju Yeon} and Han, {Myung Guk} and Chun Kang and Kim, {June Myung} and Choi, {Jun Yong}",
year = "2017",
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language = "English",
volume = "49",
pages = "194--205",
journal = "Infection and Chemotherapy",
issn = "2093-2340",
publisher = "Taehan Kamyom Hakhoe, Taehan Hwahak Yopop Hakhoe",
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}

The prevalence and risk factors of renal insufficiency among Korean HIV-infected patients : The Korea HIV/AIDS cohort study. / The Korea HIV/AIDS Cohort Study.

In: Infection and Chemotherapy, Vol. 49, No. 3, 01.01.2017, p. 194-205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The prevalence and risk factors of renal insufficiency among Korean HIV-infected patients

T2 - The Korea HIV/AIDS cohort study

AU - The Korea HIV/AIDS Cohort Study

AU - Kim, Eun Jin

AU - Ahn, Jin Young

AU - Kim, Youn Jeong

AU - Wie, Seong Heon

AU - Park, Dae Won

AU - Song, Joon Young

AU - Choi, Hee Jung

AU - Chang, Hyun Ha

AU - Choi, Bo Youl

AU - Choi, Yunsu

AU - Choi, Ju Yeon

AU - Han, Myung Guk

AU - Kang, Chun

AU - Kim, June Myung

AU - Choi, Jun Yong

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Renal disease is one of the leading causes of morbidity and mortality among people infected with human immunodeficiency virus (HIV). However, there are very few published studies about renal insufficiency in HIV-infected persons in Asia, especially in South Korea. Materials and Methods: A cross-sectional study was performed to investigate the prevalence and risk factors of renal insufficiency, defined as < 60 mL/min/1.73 m 2 , in subjects in the Korea HIV/AIDS Cohort Study enrolled from 19 institutions between December 2006 and July 2013. Data at entry into the cohort were analyzed. Results: Of 454 enrolled subjects, 24 (5.3%) showed renal insufficiency at entry into the cohort. The mean age of patients in the renal insufficiency group was 5.28 years and the majority were male subjects (91.7%). All the patients were receiving antiretroviral agents, mostly protease inhibitor-based regimens (76.4%), for an average of 19 months. In univariate analysis, older age (P = 0.002), diabetes mellitus (DM) (P = 0.0002), unknown route of transmission (P = 0.007), and taking indinavir (P = 0.0022) were associated with renal insufficiency. In multivariable analysis, older age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.03-1.12, P = 0.002], DM [OR 3.03, 95% CI 1.17-7.82, P = 0.022], unknown route of transmission [OR 6.15, 95% CI 1.77-21.33, P = 0.004], and taking indinavir [OR 3.07, 95% CI 1.17-8.05, P = 0.023] were independent risk factors of renal insufficiency. treatConclusion: The prevalence of renal insufficiency in HIV-infected subjects in this study was relatively low, similar to that in other countries. Aging, DM, and taking indinavir were significantly associated with decreased glomerular filtration rate. Furthermore, unknown route of transmission was an independent risk factor, which was interpreted as a reflection of patient compliance. Further studies on the incidence and risk factors of renal insufficiency during HIV infection using follow-up cohort data are necessary.

AB - Background: Renal disease is one of the leading causes of morbidity and mortality among people infected with human immunodeficiency virus (HIV). However, there are very few published studies about renal insufficiency in HIV-infected persons in Asia, especially in South Korea. Materials and Methods: A cross-sectional study was performed to investigate the prevalence and risk factors of renal insufficiency, defined as < 60 mL/min/1.73 m 2 , in subjects in the Korea HIV/AIDS Cohort Study enrolled from 19 institutions between December 2006 and July 2013. Data at entry into the cohort were analyzed. Results: Of 454 enrolled subjects, 24 (5.3%) showed renal insufficiency at entry into the cohort. The mean age of patients in the renal insufficiency group was 5.28 years and the majority were male subjects (91.7%). All the patients were receiving antiretroviral agents, mostly protease inhibitor-based regimens (76.4%), for an average of 19 months. In univariate analysis, older age (P = 0.002), diabetes mellitus (DM) (P = 0.0002), unknown route of transmission (P = 0.007), and taking indinavir (P = 0.0022) were associated with renal insufficiency. In multivariable analysis, older age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.03-1.12, P = 0.002], DM [OR 3.03, 95% CI 1.17-7.82, P = 0.022], unknown route of transmission [OR 6.15, 95% CI 1.77-21.33, P = 0.004], and taking indinavir [OR 3.07, 95% CI 1.17-8.05, P = 0.023] were independent risk factors of renal insufficiency. treatConclusion: The prevalence of renal insufficiency in HIV-infected subjects in this study was relatively low, similar to that in other countries. Aging, DM, and taking indinavir were significantly associated with decreased glomerular filtration rate. Furthermore, unknown route of transmission was an independent risk factor, which was interpreted as a reflection of patient compliance. Further studies on the incidence and risk factors of renal insufficiency during HIV infection using follow-up cohort data are necessary.

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U2 - 10.3947/ic.2017.49.3.194

DO - 10.3947/ic.2017.49.3.194

M3 - Article

AN - SCOPUS:85030158455

VL - 49

SP - 194

EP - 205

JO - Infection and Chemotherapy

JF - Infection and Chemotherapy

SN - 2093-2340

IS - 3

ER -