Although type 2 diabetes mellitus (T2DM) has been associated with an increase in fracture risk, there is no data regarding the prevalence of vertebral fractures or its risk factors for patients with T2DM in Korea. In this cross-sectional study, we recruited postmenopausal women with T2DM from 24 tertiary hospital diabetes clinics in Korea. Prevalent vertebral fractures were identified on lateral spinal radiographs of thoracolumbar vertebrae by vertebral morphometry. Demographic and biochemical characteristics related to diabetes were obtained, and bone mineral density of the lumbar spine and femoral neck, which was available in 752 (33.6 %) and 675 (30.1 %) patients, respectively, was also analyzed. Of the 2239 subjects recruited (mean age 63.9 years), a total of 970 (43.3 %) subjects had vertebral fractures. In the bivariate analysis, history of fragility fractures after 50 years of age, microalbuminuria, presence of cardiovascular disease (myocardial infarction, angina, cerebrovascular complications of cardiovascular disease), and presence of osteoporosis at the total hip were significantly associated with the presence of vertebral fractures, after adjusting for age. In the multivariate analysis, the presence of cardiovascular diseases in addition to advancing age and history of fragility fractures was significantly associated with increased odds of vertebral fractures. Vertebral fractures were highly prevalent in postmenopausal women with T2DM in this study conducted in Korea, and the presence of cardiovascular disease, in addition to older age and history of fragility fractures, was significantly associated with the presence of vertebral fractures.
Bibliographical noteFunding Information:
We thank all the participants and research staff involved in this multicenter study. We also acknowledge the data management support of C&R Research in the preparation of this manuscript. Editorial assistance was provided by Dr. Sujata Shah of the Asia–Pacific Medical Writing Team (AMRIT) of Sanofi-Aventis. This work was supported by Sanofi-Aventis Korea. Participating investigators include Chan Soo Shin of Seoul National University College of Medicine, In-Kyu Lee of the Kyungpook National University School of Medicine, Yoon-Sok Chung of the Ajou University School of Medicine, Hong Sun Baek of the Chonbuk National University Hospital, Dong-Jin Chung of the Chonnam National University College of Medicine, Moon-Gi Choi of the Hallym University Sacred Heart Hospital, Minho Shong of the Chungnam National University School of Medicine, Ho-Sang Shon of the Catholic University of Daegu School of Medicine, Mi-Kyung Park of the Dong-A University Medical Center, Kyung Wan Min of the Eulji University Hospital, Kang-Seo Park of the Eulji University School of Medicine, Jin-Yub Kim of the Gangneung Asan Hospital, Jae Myung Yoo of the Hallym University Kangnam Sacred Heart Hospital, Jeong Hyun Park of the Inje University College of Medicine, Hyoung-Keun Oh of the Inje University Ilsan Paik Hospital, Hye Soon Kim of the Keimyung University School of Medicine, Suk Chon of the KyungHee University School of Medicine, Mi Kyung Kim of the Maryknoll Medical Center, Young Duk Song of the National Health Insurance Corporation Ilsan Hospital, Sung-Kil Lim of the Yonsei University College of Medicinel, Ji Oh Mok of the Soonchunhyang University Bucheon Hospital, Soon Jib Yoo of the Catholic University of Korea School of Medicine, Bong-Yun Cha of the Catholic University of Korea School of Medicine Seoul St. Mary’s Hospital,and Young-IL Kim of the Ulsan University Hospital.
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Orthopedics and Sports Medicine