The prevalence of and risk factors for barrett's esophagus in a Korean population

A nationwide multicenter prospective study

Jong Jae Park, Jae Woo Kim, Hyun Jin Kim, Moon Gi Chung, Seon Mee Park, Gwang Ho Baik, Byung Kyu Nah, Su Youn Nam, Kang Seok Seo, Byung Sung Ko, Jae Young Jang, Byeong Gwan Kim, Ji Won Kim, Youn Seon Choi, Moon Kyung Joo, Jin Il Kim, Meeyon Cho, Nayoung Kim, Soo Heon Park, Hyun Chae Jung & 1 others In Sik Chung

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of this study was to evaluate the prevalence of Barrett's esophagus (BE) in the general Korean population by evaluating screening esophagogastroduodenoscopy. In addition, the risk factors for BE were identified. Method: An esophagogastroduodenoscopy examination was performed in 25,536 subjects who had upper endoscopy screening from January 2006 to July 2006. Results: Two hundred and fifteen subjects were confirmed to have BE by pathology, thus the prevalence of BE was calculated to be 0.84%. The endoscopic findings were subdivided into 2 groups: BE without reflux esophagitis (RE), which included 167 (77.7%), and BE with RE, which included 48 (22.3%). The analysis of symptoms showed that only 60.1% of the subjects with BE had reflux symptoms. Chest pain [odds ratio (OR): 1.48, 95% confidence interval (CI): 1.04-2.11] and epigastric soreness (OR: 1.42, 95% CI: 1.05-1.93) were found more frequently in the subjects with BE compared with the normal subjects. The multivariate analysis showed that the risk factors for all subjects with BE were a male sex (OR: 1.82, 95% CI: 1.32-2.50), nonsteroidal anti-inflammatory drug use (OR: 2.02, 95% CI: 1.28-3.20), hiatal hernia (OR: 5.66, 95% CI: 3.70-8.66), and an age ≥60 compared with an age <40 (OR: 1.81, 95% CI: 1.07-3.09). There was no significant difference associated with RE. Conclusions: The prevalence of BE in Korean patients presenting for a routine health check-up was 0.84%, lower than reported in Western countries. Among the subjects with BE 77.7% did not have endoscopic erosions and there were no reflux symptoms in 39.9%. These results suggest that regular endoscopic screening with a high index of suspicion is necessary for the diagnosis of BE.

Original languageEnglish
Pages (from-to)907-914
Number of pages8
JournalJournal of Clinical Gastroenterology
Volume43
Issue number10
DOIs
Publication statusPublished - 2009 Nov 1

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Barrett Esophagus
Multicenter Studies
Prospective Studies
Population
Odds Ratio
Confidence Intervals
Peptic Esophagitis
Digestive System Endoscopy
Hiatal Hernia
Sex Ratio
Chest Pain
Endoscopy
Anti-Inflammatory Agents
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Park, Jong Jae ; Kim, Jae Woo ; Kim, Hyun Jin ; Chung, Moon Gi ; Park, Seon Mee ; Baik, Gwang Ho ; Nah, Byung Kyu ; Nam, Su Youn ; Seo, Kang Seok ; Ko, Byung Sung ; Jang, Jae Young ; Kim, Byeong Gwan ; Kim, Ji Won ; Choi, Youn Seon ; Joo, Moon Kyung ; Kim, Jin Il ; Cho, Meeyon ; Kim, Nayoung ; Park, Soo Heon ; Jung, Hyun Chae ; Chung, In Sik. / The prevalence of and risk factors for barrett's esophagus in a Korean population : A nationwide multicenter prospective study. In: Journal of Clinical Gastroenterology. 2009 ; Vol. 43, No. 10. pp. 907-914.
@article{186575fa2510458bb6579852939614c9,
title = "The prevalence of and risk factors for barrett's esophagus in a Korean population: A nationwide multicenter prospective study",
abstract = "Objective: The aim of this study was to evaluate the prevalence of Barrett's esophagus (BE) in the general Korean population by evaluating screening esophagogastroduodenoscopy. In addition, the risk factors for BE were identified. Method: An esophagogastroduodenoscopy examination was performed in 25,536 subjects who had upper endoscopy screening from January 2006 to July 2006. Results: Two hundred and fifteen subjects were confirmed to have BE by pathology, thus the prevalence of BE was calculated to be 0.84{\%}. The endoscopic findings were subdivided into 2 groups: BE without reflux esophagitis (RE), which included 167 (77.7{\%}), and BE with RE, which included 48 (22.3{\%}). The analysis of symptoms showed that only 60.1{\%} of the subjects with BE had reflux symptoms. Chest pain [odds ratio (OR): 1.48, 95{\%} confidence interval (CI): 1.04-2.11] and epigastric soreness (OR: 1.42, 95{\%} CI: 1.05-1.93) were found more frequently in the subjects with BE compared with the normal subjects. The multivariate analysis showed that the risk factors for all subjects with BE were a male sex (OR: 1.82, 95{\%} CI: 1.32-2.50), nonsteroidal anti-inflammatory drug use (OR: 2.02, 95{\%} CI: 1.28-3.20), hiatal hernia (OR: 5.66, 95{\%} CI: 3.70-8.66), and an age ≥60 compared with an age <40 (OR: 1.81, 95{\%} CI: 1.07-3.09). There was no significant difference associated with RE. Conclusions: The prevalence of BE in Korean patients presenting for a routine health check-up was 0.84{\%}, lower than reported in Western countries. Among the subjects with BE 77.7{\%} did not have endoscopic erosions and there were no reflux symptoms in 39.9{\%}. These results suggest that regular endoscopic screening with a high index of suspicion is necessary for the diagnosis of BE.",
author = "Park, {Jong Jae} and Kim, {Jae Woo} and Kim, {Hyun Jin} and Chung, {Moon Gi} and Park, {Seon Mee} and Baik, {Gwang Ho} and Nah, {Byung Kyu} and Nam, {Su Youn} and Seo, {Kang Seok} and Ko, {Byung Sung} and Jang, {Jae Young} and Kim, {Byeong Gwan} and Kim, {Ji Won} and Choi, {Youn Seon} and Joo, {Moon Kyung} and Kim, {Jin Il} and Meeyon Cho and Nayoung Kim and Park, {Soo Heon} and Jung, {Hyun Chae} and Chung, {In Sik}",
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Park, JJ, Kim, JW, Kim, HJ, Chung, MG, Park, SM, Baik, GH, Nah, BK, Nam, SY, Seo, KS, Ko, BS, Jang, JY, Kim, BG, Kim, JW, Choi, YS, Joo, MK, Kim, JI, Cho, M, Kim, N, Park, SH, Jung, HC & Chung, IS 2009, 'The prevalence of and risk factors for barrett's esophagus in a Korean population: A nationwide multicenter prospective study', Journal of Clinical Gastroenterology, vol. 43, no. 10, pp. 907-914. https://doi.org/10.1097/MCG.0b013e318196bd11

The prevalence of and risk factors for barrett's esophagus in a Korean population : A nationwide multicenter prospective study. / Park, Jong Jae; Kim, Jae Woo; Kim, Hyun Jin; Chung, Moon Gi; Park, Seon Mee; Baik, Gwang Ho; Nah, Byung Kyu; Nam, Su Youn; Seo, Kang Seok; Ko, Byung Sung; Jang, Jae Young; Kim, Byeong Gwan; Kim, Ji Won; Choi, Youn Seon; Joo, Moon Kyung; Kim, Jin Il; Cho, Meeyon; Kim, Nayoung; Park, Soo Heon; Jung, Hyun Chae; Chung, In Sik.

In: Journal of Clinical Gastroenterology, Vol. 43, No. 10, 01.11.2009, p. 907-914.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The prevalence of and risk factors for barrett's esophagus in a Korean population

T2 - A nationwide multicenter prospective study

AU - Park, Jong Jae

AU - Kim, Jae Woo

AU - Kim, Hyun Jin

AU - Chung, Moon Gi

AU - Park, Seon Mee

AU - Baik, Gwang Ho

AU - Nah, Byung Kyu

AU - Nam, Su Youn

AU - Seo, Kang Seok

AU - Ko, Byung Sung

AU - Jang, Jae Young

AU - Kim, Byeong Gwan

AU - Kim, Ji Won

AU - Choi, Youn Seon

AU - Joo, Moon Kyung

AU - Kim, Jin Il

AU - Cho, Meeyon

AU - Kim, Nayoung

AU - Park, Soo Heon

AU - Jung, Hyun Chae

AU - Chung, In Sik

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Objective: The aim of this study was to evaluate the prevalence of Barrett's esophagus (BE) in the general Korean population by evaluating screening esophagogastroduodenoscopy. In addition, the risk factors for BE were identified. Method: An esophagogastroduodenoscopy examination was performed in 25,536 subjects who had upper endoscopy screening from January 2006 to July 2006. Results: Two hundred and fifteen subjects were confirmed to have BE by pathology, thus the prevalence of BE was calculated to be 0.84%. The endoscopic findings were subdivided into 2 groups: BE without reflux esophagitis (RE), which included 167 (77.7%), and BE with RE, which included 48 (22.3%). The analysis of symptoms showed that only 60.1% of the subjects with BE had reflux symptoms. Chest pain [odds ratio (OR): 1.48, 95% confidence interval (CI): 1.04-2.11] and epigastric soreness (OR: 1.42, 95% CI: 1.05-1.93) were found more frequently in the subjects with BE compared with the normal subjects. The multivariate analysis showed that the risk factors for all subjects with BE were a male sex (OR: 1.82, 95% CI: 1.32-2.50), nonsteroidal anti-inflammatory drug use (OR: 2.02, 95% CI: 1.28-3.20), hiatal hernia (OR: 5.66, 95% CI: 3.70-8.66), and an age ≥60 compared with an age <40 (OR: 1.81, 95% CI: 1.07-3.09). There was no significant difference associated with RE. Conclusions: The prevalence of BE in Korean patients presenting for a routine health check-up was 0.84%, lower than reported in Western countries. Among the subjects with BE 77.7% did not have endoscopic erosions and there were no reflux symptoms in 39.9%. These results suggest that regular endoscopic screening with a high index of suspicion is necessary for the diagnosis of BE.

AB - Objective: The aim of this study was to evaluate the prevalence of Barrett's esophagus (BE) in the general Korean population by evaluating screening esophagogastroduodenoscopy. In addition, the risk factors for BE were identified. Method: An esophagogastroduodenoscopy examination was performed in 25,536 subjects who had upper endoscopy screening from January 2006 to July 2006. Results: Two hundred and fifteen subjects were confirmed to have BE by pathology, thus the prevalence of BE was calculated to be 0.84%. The endoscopic findings were subdivided into 2 groups: BE without reflux esophagitis (RE), which included 167 (77.7%), and BE with RE, which included 48 (22.3%). The analysis of symptoms showed that only 60.1% of the subjects with BE had reflux symptoms. Chest pain [odds ratio (OR): 1.48, 95% confidence interval (CI): 1.04-2.11] and epigastric soreness (OR: 1.42, 95% CI: 1.05-1.93) were found more frequently in the subjects with BE compared with the normal subjects. The multivariate analysis showed that the risk factors for all subjects with BE were a male sex (OR: 1.82, 95% CI: 1.32-2.50), nonsteroidal anti-inflammatory drug use (OR: 2.02, 95% CI: 1.28-3.20), hiatal hernia (OR: 5.66, 95% CI: 3.70-8.66), and an age ≥60 compared with an age <40 (OR: 1.81, 95% CI: 1.07-3.09). There was no significant difference associated with RE. Conclusions: The prevalence of BE in Korean patients presenting for a routine health check-up was 0.84%, lower than reported in Western countries. Among the subjects with BE 77.7% did not have endoscopic erosions and there were no reflux symptoms in 39.9%. These results suggest that regular endoscopic screening with a high index of suspicion is necessary for the diagnosis of BE.

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