The prevalence study on restriction fragment length polymorphism analysis for the detection of hemophilia A carrier.

K. S. Song, C. H. Lee, C. S. Chung, K. Lee, Y. H. Yang, K. Y. Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have analyzed two (BclI and XbaI) intragenic restriction fragment length polymorphisms (RFLPs) and St14 (DXS52) variable number of tandem repeats (VNTR) by rapid PCR method in 97 unrelated normal subjects. The incidences for positive Bc1I and XbaI polymorphic sites in the Koreans were 81% and 72%, respectively, which were higher than other ethnic groups but similar to that reported in the Chinese or Japanese, giving the heterozygosity rate of 0.32 and 0.40, respectively. The amplified allele size was 880 bp with no other polymorphism in the analysis of St14 (DXS52) VNTR. This finding should be taken into account in the planning of a prenatal diagnosis program for ethnic Koreans.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalYonsei medical journal
Volume34
Issue number3
DOIs
Publication statusPublished - 1993 Sep

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Minisatellite Repeats
Hemophilia A
Restriction Fragment Length Polymorphisms
Cross-Sectional Studies
Prenatal Diagnosis
Ethnic Groups
Alleles
Polymerase Chain Reaction
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Song, K. S. ; Lee, C. H. ; Chung, C. S. ; Lee, K. ; Yang, Y. H. ; Kim, K. Y. / The prevalence study on restriction fragment length polymorphism analysis for the detection of hemophilia A carrier. In: Yonsei medical journal. 1993 ; Vol. 34, No. 3. pp. 239-242.
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The prevalence study on restriction fragment length polymorphism analysis for the detection of hemophilia A carrier. / Song, K. S.; Lee, C. H.; Chung, C. S.; Lee, K.; Yang, Y. H.; Kim, K. Y.

In: Yonsei medical journal, Vol. 34, No. 3, 09.1993, p. 239-242.

Research output: Contribution to journalArticle

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