The preventive effects of Bcl-2 and Bcl-xL on lovastatin-induced apoptosis of C6 glial cells

Jae Won Choi, Jong Min Lee, Young Jun Oh

Research output: Contribution to journalArticle

Abstract

It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25 μM)-induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalKorean Journal of Physiology and Pharmacology
Volume6
Issue number5
Publication statusPublished - 2002 Oct 1

Fingerprint

Lovastatin
Neuroglia
Apoptosis
Cell Proliferation
Poly(ADP-ribose) Polymerases
DNA Fragmentation
Chromatin
Cell Death
Cell Membrane
Cell Line
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

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abstract = "It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25 μM)-induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.",
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The preventive effects of Bcl-2 and Bcl-xL on lovastatin-induced apoptosis of C6 glial cells. / Choi, Jae Won; Lee, Jong Min; Oh, Young Jun.

In: Korean Journal of Physiology and Pharmacology, Vol. 6, No. 5, 01.10.2002, p. 235-239.

Research output: Contribution to journalArticle

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