Abstract
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25 μM)-induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.
| Original language | English |
|---|---|
| Pages (from-to) | 235-239 |
| Number of pages | 5 |
| Journal | Korean Journal of Physiology and Pharmacology |
| Volume | 6 |
| Issue number | 5 |
| Publication status | Published - 2002 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Physiology
- Pharmacology
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The preventive effects of Bcl-2 and Bcl-xL on lovastatin-induced apoptosis of C6 glial cells. / Choi, Jae Won; Lee, Jong Min; Oh, Young Jun.
In: Korean Journal of Physiology and Pharmacology, Vol. 6, No. 5, 01.10.2002, p. 235-239.Research output: Contribution to journal › Article
TY - JOUR
T1 - The preventive effects of Bcl-2 and Bcl-xL on lovastatin-induced apoptosis of C6 glial cells
AU - Choi, Jae Won
AU - Lee, Jong Min
AU - Oh, Young Jun
PY - 2002/10/1
Y1 - 2002/10/1
N2 - It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25 μM)-induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.
AB - It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25 μM)-induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.
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M3 - Article
AN - SCOPUS:0036818860
VL - 6
SP - 235
EP - 239
JO - Korean Journal of Physiology and Pharmacology
JF - Korean Journal of Physiology and Pharmacology
SN - 1226-4512
IS - 5
ER -