Abstract
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25 μM)-induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.
| Original language | English |
|---|---|
| Pages (from-to) | 235-239 |
| Number of pages | 5 |
| Journal | Korean Journal of Physiology and Pharmacology |
| Volume | 6 |
| Issue number | 5 |
| Publication status | Published - 2002 Oct 1 |
All Science Journal Classification (ASJC) codes
- Physiology
- Pharmacology
Fingerprint Dive into the research topics of 'The preventive effects of Bcl-2 and Bcl-x<sub>L</sub> on lovastatin-induced apoptosis of C6 glial cells'. Together they form a unique fingerprint.
Cite this
Choi, J. W., Lee, J. M., & Oh, Y. J. (2002). The preventive effects of Bcl-2 and Bcl-xL on lovastatin-induced apoptosis of C6 glial cells. Korean Journal of Physiology and Pharmacology, 6(5), 235-239.