The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma

Hyunsoo Cho, SeHoon Kim, Soo Jeong Kim, Jong Hee Chang, Woo Ick Yang, Chang-Ok Suh, June Won Cheong, Yu Ri Kim, Jung Yeon Lee, Ji Eun Jang, Yundeok Kim, Yoo Hong Min, Jinseok Kim

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Abstract

The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, we examined the prognostic significance of CD68 and FoxP3 expression in tumor samples of 76 newly diagnosed immunocompetent PCNSL patients. All patients were treated initially with high-dose methotrexate (HD-MTX)-based chemotherapy, and 16 (21.1%) patients received upfront autologous stem cell transplantation (ASCT) consolidation. High expression of CD68 (>55 cells/high-power field) or FoxP3 (>15 cells/high-power field) was observed in 10 patients, respectively. High CD68 expression was associated with inferior overall survival (OS) and progression-free survival (PFS) in multivariate analysis (P = 0.023 and P = 0.021, respectively). In addition, we performed subgroup analysis based on upfront ASCT. High CD68 expression was also associated with inferior OS and PFS in multivariate analysis (P = 0.013 and P < 0.001, respectively) among patients who did not receive upfront ASCT (n = 60), but not in patients who received upfront ASCT. The expression of FoxP3 was not significantly associated with survival. Therefore, we identified a prognostic significance of high CD68 expression in PCNSL, which suggests a need for further clinical trials and biological studies on the role of PCNSL tumor microenvironment.

Original languageEnglish
Pages (from-to)1163-1173
Number of pages11
JournalAnnals of Hematology
Volume96
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1

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All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Cho, H., Kim, S., Kim, S. J., Chang, J. H., Yang, W. I., Suh, C-O., Cheong, J. W., Kim, Y. R., Lee, J. Y., Jang, J. E., Kim, Y., Min, Y. H., & Kim, J. (2017). The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma. Annals of Hematology, 96(7), 1163-1173. https://doi.org/10.1007/s00277-017-3014-x