Abstract
Background: Chronic skin exposure to ultraviolet (UV) light increases reactive oxygen species (ROS) and stimulates the expression of matrix metalloproteinases (MMPs) through c-Jun and c-Fos activation. These signaling cascades induce the degradation of extracellular matrix (ECM) components, resulting in photoaging. Methods: This study evaluated the preventive effect of the ethanol extract of Kaempferia parvifloraWall. ex. Baker (black ginger) on UVB-induced photoaging in vivo. To investigate the antiphotoaging effect of K.parviflora extract (KPE), UVB-irradiated hairless mice administered oral doses of KPE (100 or 200mg/kg/day) for 13 weeks. Results: In comparison to the UVB control group, KPE significantly prevented wrinkle formation and the loss of collagen fibers with increased type I, III, and VII collagen genes (COL1A1, COL3A1, and COL7A1). The decrease in wrinkle formation was associated with a significant reduction in the UVB-induced expression of MMP-2, MMP-3, MMP-9, and MMP-13 via the suppression of c-Jun and c-Fos activity. KPE also increased the expression of catalase, which acts as an antioxidant enzyme in skin. In addition, expression of inflammatory mediators, such as nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), and cyclooxygenase-2 (COX-2), was significantly reduced by KPE treatment. Conclusion: The results show that oral administration of KPE significantly prevents UVB-induced photoaging in hairless mice, suggesting its potential as a natural antiphotoaging material.
| Original language | English |
|---|---|
| Pages (from-to) | 237-245 |
| Number of pages | 9 |
| Journal | Photodermatology Photoimmunology and Photomedicine |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Radiology Nuclear Medicine and imaging
- Dermatology
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The protective effect of kaempferia parviflora extract on UVB-induced skin photoaging in hairless mice. / Park, Ji Eun; Pyun, Hee Bong; Woo, Seon Wook; Jeong, Jae Hong; Hwang, Jae-Kwan.
In: Photodermatology Photoimmunology and Photomedicine, Vol. 30, No. 5, 01.10.2014, p. 237-245.Research output: Contribution to journal › Article
TY - JOUR
T1 - The protective effect of kaempferia parviflora extract on UVB-induced skin photoaging in hairless mice
AU - Park, Ji Eun
AU - Pyun, Hee Bong
AU - Woo, Seon Wook
AU - Jeong, Jae Hong
AU - Hwang, Jae-Kwan
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background: Chronic skin exposure to ultraviolet (UV) light increases reactive oxygen species (ROS) and stimulates the expression of matrix metalloproteinases (MMPs) through c-Jun and c-Fos activation. These signaling cascades induce the degradation of extracellular matrix (ECM) components, resulting in photoaging. Methods: This study evaluated the preventive effect of the ethanol extract of Kaempferia parvifloraWall. ex. Baker (black ginger) on UVB-induced photoaging in vivo. To investigate the antiphotoaging effect of K.parviflora extract (KPE), UVB-irradiated hairless mice administered oral doses of KPE (100 or 200mg/kg/day) for 13 weeks. Results: In comparison to the UVB control group, KPE significantly prevented wrinkle formation and the loss of collagen fibers with increased type I, III, and VII collagen genes (COL1A1, COL3A1, and COL7A1). The decrease in wrinkle formation was associated with a significant reduction in the UVB-induced expression of MMP-2, MMP-3, MMP-9, and MMP-13 via the suppression of c-Jun and c-Fos activity. KPE also increased the expression of catalase, which acts as an antioxidant enzyme in skin. In addition, expression of inflammatory mediators, such as nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), and cyclooxygenase-2 (COX-2), was significantly reduced by KPE treatment. Conclusion: The results show that oral administration of KPE significantly prevents UVB-induced photoaging in hairless mice, suggesting its potential as a natural antiphotoaging material.
AB - Background: Chronic skin exposure to ultraviolet (UV) light increases reactive oxygen species (ROS) and stimulates the expression of matrix metalloproteinases (MMPs) through c-Jun and c-Fos activation. These signaling cascades induce the degradation of extracellular matrix (ECM) components, resulting in photoaging. Methods: This study evaluated the preventive effect of the ethanol extract of Kaempferia parvifloraWall. ex. Baker (black ginger) on UVB-induced photoaging in vivo. To investigate the antiphotoaging effect of K.parviflora extract (KPE), UVB-irradiated hairless mice administered oral doses of KPE (100 or 200mg/kg/day) for 13 weeks. Results: In comparison to the UVB control group, KPE significantly prevented wrinkle formation and the loss of collagen fibers with increased type I, III, and VII collagen genes (COL1A1, COL3A1, and COL7A1). The decrease in wrinkle formation was associated with a significant reduction in the UVB-induced expression of MMP-2, MMP-3, MMP-9, and MMP-13 via the suppression of c-Jun and c-Fos activity. KPE also increased the expression of catalase, which acts as an antioxidant enzyme in skin. In addition, expression of inflammatory mediators, such as nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), and cyclooxygenase-2 (COX-2), was significantly reduced by KPE treatment. Conclusion: The results show that oral administration of KPE significantly prevents UVB-induced photoaging in hairless mice, suggesting its potential as a natural antiphotoaging material.
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UR - http://www.scopus.com/inward/citedby.url?scp=84916941677&partnerID=8YFLogxK
U2 - 10.1111/phpp.12097
DO - 10.1111/phpp.12097
M3 - Article
C2 - 24313661
AN - SCOPUS:84916941677
VL - 30
SP - 237
EP - 245
JO - Photodermatology Photoimmunology and Photomedicine
JF - Photodermatology Photoimmunology and Photomedicine
SN - 0905-4383
IS - 5
ER -