The protective effect of kaempferia parviflora extract on UVB-induced skin photoaging in hairless mice

Ji Eun Park, Hee Bong Pyun, Seon Wook Woo, Jae Hong Jeong, Jae-Kwan Hwang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Chronic skin exposure to ultraviolet (UV) light increases reactive oxygen species (ROS) and stimulates the expression of matrix metalloproteinases (MMPs) through c-Jun and c-Fos activation. These signaling cascades induce the degradation of extracellular matrix (ECM) components, resulting in photoaging. Methods: This study evaluated the preventive effect of the ethanol extract of Kaempferia parvifloraWall. ex. Baker (black ginger) on UVB-induced photoaging in vivo. To investigate the antiphotoaging effect of K.parviflora extract (KPE), UVB-irradiated hairless mice administered oral doses of KPE (100 or 200mg/kg/day) for 13 weeks. Results: In comparison to the UVB control group, KPE significantly prevented wrinkle formation and the loss of collagen fibers with increased type I, III, and VII collagen genes (COL1A1, COL3A1, and COL7A1). The decrease in wrinkle formation was associated with a significant reduction in the UVB-induced expression of MMP-2, MMP-3, MMP-9, and MMP-13 via the suppression of c-Jun and c-Fos activity. KPE also increased the expression of catalase, which acts as an antioxidant enzyme in skin. In addition, expression of inflammatory mediators, such as nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), and cyclooxygenase-2 (COX-2), was significantly reduced by KPE treatment. Conclusion: The results show that oral administration of KPE significantly prevents UVB-induced photoaging in hairless mice, suggesting its potential as a natural antiphotoaging material.

Original languageEnglish
Pages (from-to)237-245
Number of pages9
JournalPhotodermatology Photoimmunology and Photomedicine
Volume30
Issue number5
DOIs
Publication statusPublished - 2014 Oct 1

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Zingiberaceae
Skin Aging
Hairless Mouse
Collagen Type VII
Matrix Metalloproteinase 13
Ginger
Matrix Metalloproteinase 3
Skin
Collagen Type III
NF-kappa B
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Cyclooxygenase 2
Ultraviolet Rays
Collagen Type I
Matrix Metalloproteinases
Interleukin-1
Catalase
Extracellular Matrix
Oral Administration

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Radiology Nuclear Medicine and imaging
  • Dermatology

Cite this

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title = "The protective effect of kaempferia parviflora extract on UVB-induced skin photoaging in hairless mice",
abstract = "Background: Chronic skin exposure to ultraviolet (UV) light increases reactive oxygen species (ROS) and stimulates the expression of matrix metalloproteinases (MMPs) through c-Jun and c-Fos activation. These signaling cascades induce the degradation of extracellular matrix (ECM) components, resulting in photoaging. Methods: This study evaluated the preventive effect of the ethanol extract of Kaempferia parvifloraWall. ex. Baker (black ginger) on UVB-induced photoaging in vivo. To investigate the antiphotoaging effect of K.parviflora extract (KPE), UVB-irradiated hairless mice administered oral doses of KPE (100 or 200mg/kg/day) for 13 weeks. Results: In comparison to the UVB control group, KPE significantly prevented wrinkle formation and the loss of collagen fibers with increased type I, III, and VII collagen genes (COL1A1, COL3A1, and COL7A1). The decrease in wrinkle formation was associated with a significant reduction in the UVB-induced expression of MMP-2, MMP-3, MMP-9, and MMP-13 via the suppression of c-Jun and c-Fos activity. KPE also increased the expression of catalase, which acts as an antioxidant enzyme in skin. In addition, expression of inflammatory mediators, such as nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), and cyclooxygenase-2 (COX-2), was significantly reduced by KPE treatment. Conclusion: The results show that oral administration of KPE significantly prevents UVB-induced photoaging in hairless mice, suggesting its potential as a natural antiphotoaging material.",
author = "Park, {Ji Eun} and Pyun, {Hee Bong} and Woo, {Seon Wook} and Jeong, {Jae Hong} and Jae-Kwan Hwang",
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The protective effect of kaempferia parviflora extract on UVB-induced skin photoaging in hairless mice. / Park, Ji Eun; Pyun, Hee Bong; Woo, Seon Wook; Jeong, Jae Hong; Hwang, Jae-Kwan.

In: Photodermatology Photoimmunology and Photomedicine, Vol. 30, No. 5, 01.10.2014, p. 237-245.

Research output: Contribution to journalArticle

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T1 - The protective effect of kaempferia parviflora extract on UVB-induced skin photoaging in hairless mice

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AU - Pyun, Hee Bong

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AU - Jeong, Jae Hong

AU - Hwang, Jae-Kwan

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N2 - Background: Chronic skin exposure to ultraviolet (UV) light increases reactive oxygen species (ROS) and stimulates the expression of matrix metalloproteinases (MMPs) through c-Jun and c-Fos activation. These signaling cascades induce the degradation of extracellular matrix (ECM) components, resulting in photoaging. Methods: This study evaluated the preventive effect of the ethanol extract of Kaempferia parvifloraWall. ex. Baker (black ginger) on UVB-induced photoaging in vivo. To investigate the antiphotoaging effect of K.parviflora extract (KPE), UVB-irradiated hairless mice administered oral doses of KPE (100 or 200mg/kg/day) for 13 weeks. Results: In comparison to the UVB control group, KPE significantly prevented wrinkle formation and the loss of collagen fibers with increased type I, III, and VII collagen genes (COL1A1, COL3A1, and COL7A1). The decrease in wrinkle formation was associated with a significant reduction in the UVB-induced expression of MMP-2, MMP-3, MMP-9, and MMP-13 via the suppression of c-Jun and c-Fos activity. KPE also increased the expression of catalase, which acts as an antioxidant enzyme in skin. In addition, expression of inflammatory mediators, such as nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), and cyclooxygenase-2 (COX-2), was significantly reduced by KPE treatment. Conclusion: The results show that oral administration of KPE significantly prevents UVB-induced photoaging in hairless mice, suggesting its potential as a natural antiphotoaging material.

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