The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy

Dae Hee Kim, Yong Jin Kim, Sung A. Chang, Hye Won Lee, Ha Na Kim, Hyung Kwan Kim, Hyuk Jae Chang, Dae Won Sohn, Young Bae Park

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6 Citations (Scopus)

Abstract

AimsTo evaluate the protective effect of thalidomide, a potent anti-inflammatory drug, on the development of diabetic cardiomyopathy (DMCMP).Methods and resultsWe induced type 1 diabetes using streptozocin in 8-week-old Sprague-Dawley rats, divided them into two groups-a thalidomide treatment group (DM-T, n = 15) and a non-treatment group (DM-N, n = 15)-and compared them with a normal control (n = 10). Ten weeks after diabetes induction, heart and lung mass indices were higher in the DM-N group compared with the control group. In the DM-T group, increases in heart and lung mass indices were attenuated compared with the DM-N group. On echocardiographic examination, systolic and diastolic mitral annulus velocities were impaired in the DM-N group, but they remained normal in the DM-T group. On haemodynamic analyses, left ventricular (LV) systolic function, represented by end-systolic elastance (0.35 ± 0.14 vs. 0.18 ± 0.07 mmHg/l, P < 0.001) and preload-recruitable stroke work (90.5 ± 24.3 vs. 51.8 ± 22.0 mmHg, P < 0.001), was preserved in the DM-T group compared with the DM-N group. Likewise, deterioration of LV diastolic function was attenuated in the DM-T group. Increases in serum levels of TNF-were attenuated in the DM-T group compared with the DM-N group. On histological analysis, thalidomide treatment lowered total myocardial collagen content and the expression of TNF-, IL-1, ICAM-1, and VCAM-1.ConclusionIn an animal model of DMCMP, deterioration of LV systolic and diastolic function was partially prevented by thalidomide treatment.

Original languageEnglish
Pages (from-to)1051-1060
Number of pages10
JournalEuropean Journal of Heart Failure
Volume12
Issue number10
DOIs
Publication statusPublished - 2010 Oct

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Kim, D. H., Kim, Y. J., Chang, S. A., Lee, H. W., Kim, H. N., Kim, H. K., Chang, H. J., Sohn, D. W., & Park, Y. B. (2010). The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy. European Journal of Heart Failure, 12(10), 1051-1060. https://doi.org/10.1093/eurjhf/hfq103