TY - JOUR
T1 - The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy
AU - Kim, Dae Hee
AU - Kim, Yong Jin
AU - Chang, Sung A.
AU - Lee, Hye Won
AU - Kim, Ha Na
AU - Kim, Hyung Kwan
AU - Chang, Hyuk Jae
AU - Sohn, Dae Won
AU - Park, Young Bae
PY - 2010/10
Y1 - 2010/10
N2 - AimsTo evaluate the protective effect of thalidomide, a potent anti-inflammatory drug, on the development of diabetic cardiomyopathy (DMCMP).Methods and resultsWe induced type 1 diabetes using streptozocin in 8-week-old Sprague-Dawley rats, divided them into two groups-a thalidomide treatment group (DM-T, n = 15) and a non-treatment group (DM-N, n = 15)-and compared them with a normal control (n = 10). Ten weeks after diabetes induction, heart and lung mass indices were higher in the DM-N group compared with the control group. In the DM-T group, increases in heart and lung mass indices were attenuated compared with the DM-N group. On echocardiographic examination, systolic and diastolic mitral annulus velocities were impaired in the DM-N group, but they remained normal in the DM-T group. On haemodynamic analyses, left ventricular (LV) systolic function, represented by end-systolic elastance (0.35 ± 0.14 vs. 0.18 ± 0.07 mmHg/l, P < 0.001) and preload-recruitable stroke work (90.5 ± 24.3 vs. 51.8 ± 22.0 mmHg, P < 0.001), was preserved in the DM-T group compared with the DM-N group. Likewise, deterioration of LV diastolic function was attenuated in the DM-T group. Increases in serum levels of TNF-were attenuated in the DM-T group compared with the DM-N group. On histological analysis, thalidomide treatment lowered total myocardial collagen content and the expression of TNF-, IL-1, ICAM-1, and VCAM-1.ConclusionIn an animal model of DMCMP, deterioration of LV systolic and diastolic function was partially prevented by thalidomide treatment.
AB - AimsTo evaluate the protective effect of thalidomide, a potent anti-inflammatory drug, on the development of diabetic cardiomyopathy (DMCMP).Methods and resultsWe induced type 1 diabetes using streptozocin in 8-week-old Sprague-Dawley rats, divided them into two groups-a thalidomide treatment group (DM-T, n = 15) and a non-treatment group (DM-N, n = 15)-and compared them with a normal control (n = 10). Ten weeks after diabetes induction, heart and lung mass indices were higher in the DM-N group compared with the control group. In the DM-T group, increases in heart and lung mass indices were attenuated compared with the DM-N group. On echocardiographic examination, systolic and diastolic mitral annulus velocities were impaired in the DM-N group, but they remained normal in the DM-T group. On haemodynamic analyses, left ventricular (LV) systolic function, represented by end-systolic elastance (0.35 ± 0.14 vs. 0.18 ± 0.07 mmHg/l, P < 0.001) and preload-recruitable stroke work (90.5 ± 24.3 vs. 51.8 ± 22.0 mmHg, P < 0.001), was preserved in the DM-T group compared with the DM-N group. Likewise, deterioration of LV diastolic function was attenuated in the DM-T group. Increases in serum levels of TNF-were attenuated in the DM-T group compared with the DM-N group. On histological analysis, thalidomide treatment lowered total myocardial collagen content and the expression of TNF-, IL-1, ICAM-1, and VCAM-1.ConclusionIn an animal model of DMCMP, deterioration of LV systolic and diastolic function was partially prevented by thalidomide treatment.
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U2 - 10.1093/eurjhf/hfq103
DO - 10.1093/eurjhf/hfq103
M3 - Article
C2 - 20601373
AN - SCOPUS:77957239226
VL - 12
SP - 1051
EP - 1060
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 10
ER -
