The RANTES -403G > A promoter polymorphism in Korean men: Association with serum RANTES concentration and coronary artery disease

Yangsoo Jang, Jey Sook Chae, Yae Jung Hyun, Soo Jeong Koh, Ji Young Kim, Min Ji Ko, Se Joong Rim, Hyun Joon Shin, Jose M. Ordovas, Jong Ho Lee

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Abstract

In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C > G and -403G > A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n = 176) or without (n = 377) Type 2 diabetes, aged 40-65 years with previous myocardial infarction (∼ 50 %) or angiographically confirmed CAD (∼ 50 %), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES -28C > G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES -403G > A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54-0.92], P = 0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the -403G > A genotype in controls (G/G: 44.7 ± 3.3 ng/ml, G/A: 36.5 ± 2.0 ng/ml, A/A: 28.7 ± 2.5 ng/ml; P < 0.001), non-diabetic CAD patients (G/G: 50.9 ± 3.0 ng/ml, G/A: 42.2 ± 2.6 ng/ml, A/A: 41.3 ± 4.4 ng/ml; P < 0.05) and diabetic CAD patients (G/G: 58.5 ± 3.5 ng/ml, G/A: 49.6 ± 4.1 ng/ml, A/A: 42.2 ± 4.3 ng/ml; P < 0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r = 0.289, P < 0.001) and platelet counts (r = 0.253, P < 0.001). The results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalClinical Science
Volume113
Issue number7-8
DOIs
Publication statusPublished - 2007 Oct 1

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Coronary Artery Disease
T-Lymphocytes
Serum
Alleles
Odds Ratio
Genotype
Platelet Count
Alcohol Drinking
C-Reactive Protein
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Body Mass Index
Smoking
Enzyme-Linked Immunosorbent Assay
Myocardial Infarction
Outcome Assessment (Health Care)
Confidence Intervals
Lipids

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jang, Yangsoo ; Chae, Jey Sook ; Hyun, Yae Jung ; Koh, Soo Jeong ; Kim, Ji Young ; Ko, Min Ji ; Rim, Se Joong ; Shin, Hyun Joon ; Ordovas, Jose M. ; Lee, Jong Ho. / The RANTES -403G > A promoter polymorphism in Korean men : Association with serum RANTES concentration and coronary artery disease. In: Clinical Science. 2007 ; Vol. 113, No. 7-8. pp. 349-356.
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abstract = "In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C > G and -403G > A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n = 176) or without (n = 377) Type 2 diabetes, aged 40-65 years with previous myocardial infarction (∼ 50 {\%}) or angiographically confirmed CAD (∼ 50 {\%}), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES -28C > G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES -403G > A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95{\%} CI (confidence interval) 0.54-0.92], P = 0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the -403G > A genotype in controls (G/G: 44.7 ± 3.3 ng/ml, G/A: 36.5 ± 2.0 ng/ml, A/A: 28.7 ± 2.5 ng/ml; P < 0.001), non-diabetic CAD patients (G/G: 50.9 ± 3.0 ng/ml, G/A: 42.2 ± 2.6 ng/ml, A/A: 41.3 ± 4.4 ng/ml; P < 0.05) and diabetic CAD patients (G/G: 58.5 ± 3.5 ng/ml, G/A: 49.6 ± 4.1 ng/ml, A/A: 42.2 ± 4.3 ng/ml; P < 0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r = 0.289, P < 0.001) and platelet counts (r = 0.253, P < 0.001). The results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk.",
author = "Yangsoo Jang and Chae, {Jey Sook} and Hyun, {Yae Jung} and Koh, {Soo Jeong} and Kim, {Ji Young} and Ko, {Min Ji} and Rim, {Se Joong} and Shin, {Hyun Joon} and Ordovas, {Jose M.} and Lee, {Jong Ho}",
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The RANTES -403G > A promoter polymorphism in Korean men : Association with serum RANTES concentration and coronary artery disease. / Jang, Yangsoo; Chae, Jey Sook; Hyun, Yae Jung; Koh, Soo Jeong; Kim, Ji Young; Ko, Min Ji; Rim, Se Joong; Shin, Hyun Joon; Ordovas, Jose M.; Lee, Jong Ho.

In: Clinical Science, Vol. 113, No. 7-8, 01.10.2007, p. 349-356.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The RANTES -403G > A promoter polymorphism in Korean men

T2 - Association with serum RANTES concentration and coronary artery disease

AU - Jang, Yangsoo

AU - Chae, Jey Sook

AU - Hyun, Yae Jung

AU - Koh, Soo Jeong

AU - Kim, Ji Young

AU - Ko, Min Ji

AU - Rim, Se Joong

AU - Shin, Hyun Joon

AU - Ordovas, Jose M.

AU - Lee, Jong Ho

PY - 2007/10/1

Y1 - 2007/10/1

N2 - In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C > G and -403G > A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n = 176) or without (n = 377) Type 2 diabetes, aged 40-65 years with previous myocardial infarction (∼ 50 %) or angiographically confirmed CAD (∼ 50 %), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES -28C > G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES -403G > A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54-0.92], P = 0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the -403G > A genotype in controls (G/G: 44.7 ± 3.3 ng/ml, G/A: 36.5 ± 2.0 ng/ml, A/A: 28.7 ± 2.5 ng/ml; P < 0.001), non-diabetic CAD patients (G/G: 50.9 ± 3.0 ng/ml, G/A: 42.2 ± 2.6 ng/ml, A/A: 41.3 ± 4.4 ng/ml; P < 0.05) and diabetic CAD patients (G/G: 58.5 ± 3.5 ng/ml, G/A: 49.6 ± 4.1 ng/ml, A/A: 42.2 ± 4.3 ng/ml; P < 0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r = 0.289, P < 0.001) and platelet counts (r = 0.253, P < 0.001). The results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk.

AB - In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C > G and -403G > A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n = 176) or without (n = 377) Type 2 diabetes, aged 40-65 years with previous myocardial infarction (∼ 50 %) or angiographically confirmed CAD (∼ 50 %), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES -28C > G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES -403G > A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54-0.92], P = 0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the -403G > A genotype in controls (G/G: 44.7 ± 3.3 ng/ml, G/A: 36.5 ± 2.0 ng/ml, A/A: 28.7 ± 2.5 ng/ml; P < 0.001), non-diabetic CAD patients (G/G: 50.9 ± 3.0 ng/ml, G/A: 42.2 ± 2.6 ng/ml, A/A: 41.3 ± 4.4 ng/ml; P < 0.05) and diabetic CAD patients (G/G: 58.5 ± 3.5 ng/ml, G/A: 49.6 ± 4.1 ng/ml, A/A: 42.2 ± 4.3 ng/ml; P < 0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r = 0.289, P < 0.001) and platelet counts (r = 0.253, P < 0.001). The results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk.

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