The RANTES -403G > A promoter polymorphism in Korean men: Association with serum RANTES concentration and coronary artery disease

Yangsoo Jang, Jey Sook Chae, Yae Jung Hyun, Soo Jeong Koh, Ji Young Kim, Min Ji Ko, Se Joong Rim, Hyun Joon Shin, Jose M. Ordovas, Jong Ho Lee

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31 Citations (Scopus)

Abstract

In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) -28C > G and -403G > A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n = 176) or without (n = 377) Type 2 diabetes, aged 40-65 years with previous myocardial infarction (∼ 50 %) or angiographically confirmed CAD (∼ 50 %), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES -28C > G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES -403G > A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54-0.92], P = 0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the -403G > A genotype in controls (G/G: 44.7 ± 3.3 ng/ml, G/A: 36.5 ± 2.0 ng/ml, A/A: 28.7 ± 2.5 ng/ml; P < 0.001), non-diabetic CAD patients (G/G: 50.9 ± 3.0 ng/ml, G/A: 42.2 ± 2.6 ng/ml, A/A: 41.3 ± 4.4 ng/ml; P < 0.05) and diabetic CAD patients (G/G: 58.5 ± 3.5 ng/ml, G/A: 49.6 ± 4.1 ng/ml, A/A: 42.2 ± 4.3 ng/ml; P < 0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r = 0.289, P < 0.001) and platelet counts (r = 0.253, P < 0.001). The results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalClinical Science
Volume113
Issue number7-8
DOIs
Publication statusPublished - 2007 Oct

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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