The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function

Daham Kim, Kwang J. Kim, Ji H. Huh, Byung Wan Lee, Eun S. Kang, Bong S. Cha, Hyun C. Lee

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Abstract

Objective Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test. Design A clinical, retrospective study. Patients and measurements A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined. Results The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI. Conclusions The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalClinical Endocrinology
Volume77
Issue number5
DOIs
Publication statusPublished - 2012 Nov 1

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Glycosylated Hemoglobin A
Insulin
Type 2 Diabetes Mellitus
Insulin Resistance
Meals
Body Mass Index
glycosylated serum albumin
Glycemic Index
Albumins
Hemoglobins
Homeostasis
Retrospective Studies
Fats
Carbohydrates

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Kim, Daham ; Kim, Kwang J. ; Huh, Ji H. ; Lee, Byung Wan ; Kang, Eun S. ; Cha, Bong S. ; Lee, Hyun C. / The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function. In: Clinical Endocrinology. 2012 ; Vol. 77, No. 5. pp. 679-683.
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abstract = "Objective Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test. Design A clinical, retrospective study. Patients and measurements A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined. Results The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI. Conclusions The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.",
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The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function. / Kim, Daham; Kim, Kwang J.; Huh, Ji H.; Lee, Byung Wan; Kang, Eun S.; Cha, Bong S.; Lee, Hyun C.

In: Clinical Endocrinology, Vol. 77, No. 5, 01.11.2012, p. 679-683.

Research output: Contribution to journalArticle

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T1 - The ratio of glycated albumin to glycated haemoglobin correlates with insulin secretory function

AU - Kim, Daham

AU - Kim, Kwang J.

AU - Huh, Ji H.

AU - Lee, Byung Wan

AU - Kang, Eun S.

AU - Cha, Bong S.

AU - Lee, Hyun C.

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N2 - Objective Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test. Design A clinical, retrospective study. Patients and measurements A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined. Results The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI. Conclusions The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.

AB - Objective Although glycated haemoglobin (A1c) levels are similar among patients with type 2 diabetes, the glycated albumin (GA)/A1c ratio varies considerably. On the basis of the hypothesis that endogenous insulin secretion might be correlated with the GA/A1c ratio, we investigated whether insulin secretory function or insulin resistance has different effects on the GA/A1c ratio in patients with type 2 diabetes using the standardized liquid meal test. Design A clinical, retrospective study. Patients and measurements A total of 758 patients with type 2 diabetes ingested a standardized liquid meal (i.e. 500 kcal, 17·5 g fat, 68·5 g carbohydrate and 17·5 g protein). The subjects were divided into two groups: those with GA/A1c ratio <2·5 (n = 414) and those with GA/A1c ratio ≥2·5 (n = 344). We compared the A1c and GA levels, and the GA/A1c ratio and evaluated the relationships between the glycaemic indices and other parameters. Effects of β-cell function [homeostasis model assessment (HOMA-β), insulinogenic index (IGI)] and insulin resistance (HOMA-IR) on the GA/A1c ratio were also examined. Results The GA/A1c ratio was significantly correlated with HOMA-β, IGI and body mass index (BMI) but not with HOMA-IR. Furthermore, after adjusting for age, gender, BMI, haemoglobin and albumin levels, the GA/A1c ratio was still inversely correlated with both HOMA-β and IGI. Conclusions The GA/A1c ratio is significantly correlated with insulin secretory function but not with insulin resistance.

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