The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer

Hyoung Il Kim, Haeryoung Kim, Hyoung Won Cho, Sang Yong Kim, Ki Jun Song, Woo Jin Hyung, Chung Gyu Park, Choong Bai Kim

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background TILs have been reported to be a prognostic factor in human cancers. We assessed the prognostic significance of tumor-infiltrating regulatory T cells in gastric cardia cancer. Methods We retrospectively reviewed the database of Severance Hospital for patients who underwent curative resection of gastric cardia cancer from Jan 2000 to Dec 2006 and identified 180 patients. Immunohistochemistry for TIL subsets was performed against CD3, CD4, CD8, Foxp3, and granzyme B in the resected tumor specimens. The absolute numbers and relative ratios of positively stained lymphocytes for each subset were evaluated. Results A high Foxp3/CD4 ratio was identified as an unfavorable prognostic factor for overall survival (OS) using univariate and multivariate analysis of all immunologic variables. Patients group with high Foxp3/CD4 ratio was associated with loco-regional recurrence (P = 0.033). In multivariate analysis for clinical and immunologic variables, the nodal status (hazards ratio-HR: 3.863, confidence interval-CI: 1.664-8.966, P = 0.002), depth of invasion (HR: 3.607, CI: 1.443-9.019, P = 0.006), and Foxp3/CD4 ratio (HR: 1.812, CI: 1.022-3.212, P = 0.042) were identified as independent prognostic factors for OS. Conclusions A higher regulatory T cells/helper T cells ratio is associated with an unfavorable prognosis and loco-regional recurrence pattern in gastric cardia cancer. J. Surg. Oncol. 2011; 104:728-733. © 2011 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)728-733
Number of pages6
JournalJournal of surgical oncology
Volume104
Issue number7
DOIs
Publication statusPublished - 2011 Dec 1

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Cardia
Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
Stomach Neoplasms
Recurrence
Multivariate Analysis
Granzymes
Neoplasms
Survival
Lymphocyte Subsets
Immunohistochemistry
Databases
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kim, Hyoung Il ; Kim, Haeryoung ; Cho, Hyoung Won ; Kim, Sang Yong ; Song, Ki Jun ; Hyung, Woo Jin ; Park, Chung Gyu ; Kim, Choong Bai. / The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer. In: Journal of surgical oncology. 2011 ; Vol. 104, No. 7. pp. 728-733.
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abstract = "Background TILs have been reported to be a prognostic factor in human cancers. We assessed the prognostic significance of tumor-infiltrating regulatory T cells in gastric cardia cancer. Methods We retrospectively reviewed the database of Severance Hospital for patients who underwent curative resection of gastric cardia cancer from Jan 2000 to Dec 2006 and identified 180 patients. Immunohistochemistry for TIL subsets was performed against CD3, CD4, CD8, Foxp3, and granzyme B in the resected tumor specimens. The absolute numbers and relative ratios of positively stained lymphocytes for each subset were evaluated. Results A high Foxp3/CD4 ratio was identified as an unfavorable prognostic factor for overall survival (OS) using univariate and multivariate analysis of all immunologic variables. Patients group with high Foxp3/CD4 ratio was associated with loco-regional recurrence (P = 0.033). In multivariate analysis for clinical and immunologic variables, the nodal status (hazards ratio-HR: 3.863, confidence interval-CI: 1.664-8.966, P = 0.002), depth of invasion (HR: 3.607, CI: 1.443-9.019, P = 0.006), and Foxp3/CD4 ratio (HR: 1.812, CI: 1.022-3.212, P = 0.042) were identified as independent prognostic factors for OS. Conclusions A higher regulatory T cells/helper T cells ratio is associated with an unfavorable prognosis and loco-regional recurrence pattern in gastric cardia cancer. J. Surg. Oncol. 2011; 104:728-733. {\circledC} 2011 Wiley Periodicals, Inc.",
author = "Kim, {Hyoung Il} and Haeryoung Kim and Cho, {Hyoung Won} and Kim, {Sang Yong} and Song, {Ki Jun} and Hyung, {Woo Jin} and Park, {Chung Gyu} and Kim, {Choong Bai}",
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The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer. / Kim, Hyoung Il; Kim, Haeryoung; Cho, Hyoung Won; Kim, Sang Yong; Song, Ki Jun; Hyung, Woo Jin; Park, Chung Gyu; Kim, Choong Bai.

In: Journal of surgical oncology, Vol. 104, No. 7, 01.12.2011, p. 728-733.

Research output: Contribution to journalArticle

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T1 - The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer

AU - Kim, Hyoung Il

AU - Kim, Haeryoung

AU - Cho, Hyoung Won

AU - Kim, Sang Yong

AU - Song, Ki Jun

AU - Hyung, Woo Jin

AU - Park, Chung Gyu

AU - Kim, Choong Bai

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N2 - Background TILs have been reported to be a prognostic factor in human cancers. We assessed the prognostic significance of tumor-infiltrating regulatory T cells in gastric cardia cancer. Methods We retrospectively reviewed the database of Severance Hospital for patients who underwent curative resection of gastric cardia cancer from Jan 2000 to Dec 2006 and identified 180 patients. Immunohistochemistry for TIL subsets was performed against CD3, CD4, CD8, Foxp3, and granzyme B in the resected tumor specimens. The absolute numbers and relative ratios of positively stained lymphocytes for each subset were evaluated. Results A high Foxp3/CD4 ratio was identified as an unfavorable prognostic factor for overall survival (OS) using univariate and multivariate analysis of all immunologic variables. Patients group with high Foxp3/CD4 ratio was associated with loco-regional recurrence (P = 0.033). In multivariate analysis for clinical and immunologic variables, the nodal status (hazards ratio-HR: 3.863, confidence interval-CI: 1.664-8.966, P = 0.002), depth of invasion (HR: 3.607, CI: 1.443-9.019, P = 0.006), and Foxp3/CD4 ratio (HR: 1.812, CI: 1.022-3.212, P = 0.042) were identified as independent prognostic factors for OS. Conclusions A higher regulatory T cells/helper T cells ratio is associated with an unfavorable prognosis and loco-regional recurrence pattern in gastric cardia cancer. J. Surg. Oncol. 2011; 104:728-733. © 2011 Wiley Periodicals, Inc.

AB - Background TILs have been reported to be a prognostic factor in human cancers. We assessed the prognostic significance of tumor-infiltrating regulatory T cells in gastric cardia cancer. Methods We retrospectively reviewed the database of Severance Hospital for patients who underwent curative resection of gastric cardia cancer from Jan 2000 to Dec 2006 and identified 180 patients. Immunohistochemistry for TIL subsets was performed against CD3, CD4, CD8, Foxp3, and granzyme B in the resected tumor specimens. The absolute numbers and relative ratios of positively stained lymphocytes for each subset were evaluated. Results A high Foxp3/CD4 ratio was identified as an unfavorable prognostic factor for overall survival (OS) using univariate and multivariate analysis of all immunologic variables. Patients group with high Foxp3/CD4 ratio was associated with loco-regional recurrence (P = 0.033). In multivariate analysis for clinical and immunologic variables, the nodal status (hazards ratio-HR: 3.863, confidence interval-CI: 1.664-8.966, P = 0.002), depth of invasion (HR: 3.607, CI: 1.443-9.019, P = 0.006), and Foxp3/CD4 ratio (HR: 1.812, CI: 1.022-3.212, P = 0.042) were identified as independent prognostic factors for OS. Conclusions A higher regulatory T cells/helper T cells ratio is associated with an unfavorable prognosis and loco-regional recurrence pattern in gastric cardia cancer. J. Surg. Oncol. 2011; 104:728-733. © 2011 Wiley Periodicals, Inc.

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