The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study

Jin Ha Yoon, Jong Ku Park, Sung Soo Oh, Ki Hyun Lee, Sung Kyung Kim, In Jung Cho, Jong Koo Kim, Hee Taik Kang, Sung Gyun Ahn, Jun Won Lee, Seung Hwan Lee, Aeyong Eom, Jang Young Kim, Song Vogue Ahn, Sang Baek Koh

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.

Original languageEnglish
Pages (from-to)2199-2205
Number of pages7
JournalClinica Chimica Acta
Volume412
Issue number23-24
DOIs
Publication statusPublished - 2011 Nov 20

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Adiponectin
Leptin
Insulin Resistance
Homeostasis
Cohort Studies
Insulin
ROC Curve
Serum
Adipokines
Metabolism
Radioimmunoassay
Fats
Biomarkers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Yoon, Jin Ha ; Park, Jong Ku ; Oh, Sung Soo ; Lee, Ki Hyun ; Kim, Sung Kyung ; Cho, In Jung ; Kim, Jong Koo ; Kang, Hee Taik ; Ahn, Sung Gyun ; Lee, Jun Won ; Lee, Seung Hwan ; Eom, Aeyong ; Kim, Jang Young ; Ahn, Song Vogue ; Koh, Sang Baek. / The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance : The Korean Genomic Rural Cohort Study. In: Clinica Chimica Acta. 2011 ; Vol. 412, No. 23-24. pp. 2199-2205.
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title = "The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study",
abstract = "Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.",
author = "Yoon, {Jin Ha} and Park, {Jong Ku} and Oh, {Sung Soo} and Lee, {Ki Hyun} and Kim, {Sung Kyung} and Cho, {In Jung} and Kim, {Jong Koo} and Kang, {Hee Taik} and Ahn, {Sung Gyun} and Lee, {Jun Won} and Lee, {Seung Hwan} and Aeyong Eom and Kim, {Jang Young} and Ahn, {Song Vogue} and Koh, {Sang Baek}",
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The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance : The Korean Genomic Rural Cohort Study. / Yoon, Jin Ha; Park, Jong Ku; Oh, Sung Soo; Lee, Ki Hyun; Kim, Sung Kyung; Cho, In Jung; Kim, Jong Koo; Kang, Hee Taik; Ahn, Sung Gyun; Lee, Jun Won; Lee, Seung Hwan; Eom, Aeyong; Kim, Jang Young; Ahn, Song Vogue; Koh, Sang Baek.

In: Clinica Chimica Acta, Vol. 412, No. 23-24, 20.11.2011, p. 2199-2205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance

T2 - The Korean Genomic Rural Cohort Study

AU - Yoon, Jin Ha

AU - Park, Jong Ku

AU - Oh, Sung Soo

AU - Lee, Ki Hyun

AU - Kim, Sung Kyung

AU - Cho, In Jung

AU - Kim, Jong Koo

AU - Kang, Hee Taik

AU - Ahn, Sung Gyun

AU - Lee, Jun Won

AU - Lee, Seung Hwan

AU - Eom, Aeyong

AU - Kim, Jang Young

AU - Ahn, Song Vogue

AU - Koh, Sang Baek

PY - 2011/11/20

Y1 - 2011/11/20

N2 - Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.

AB - Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.

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DO - 10.1016/j.cca.2011.08.003

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