The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study

JinHa Yoon, Jong Ku Park, Sung Soo Oh, Ki Hyun Lee, Sung Kyung Kim, In Jung Cho, Jong Koo Kim, Hee Taik Kang, Sung Gyun Ahn, Junwon Lee, Seunghwan Lee, Aeyong Eom, Jang Young Kim, Songvogue Ahn, Sangbaek Koh

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.

Original languageEnglish
Pages (from-to)2199-2205
Number of pages7
JournalClinica Chimica Acta
Volume412
Issue number23-24
DOIs
Publication statusPublished - 2011 Nov 20

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Adiponectin
Leptin
Insulin Resistance
Homeostasis
Cohort Studies
Insulin
ROC Curve
Serum
Adipokines
Metabolism
Radioimmunoassay
Fats
Biomarkers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Yoon, JinHa ; Park, Jong Ku ; Oh, Sung Soo ; Lee, Ki Hyun ; Kim, Sung Kyung ; Cho, In Jung ; Kim, Jong Koo ; Kang, Hee Taik ; Ahn, Sung Gyun ; Lee, Junwon ; Lee, Seunghwan ; Eom, Aeyong ; Kim, Jang Young ; Ahn, Songvogue ; Koh, Sangbaek. / The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance : The Korean Genomic Rural Cohort Study. In: Clinica Chimica Acta. 2011 ; Vol. 412, No. 23-24. pp. 2199-2205.
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title = "The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance: The Korean Genomic Rural Cohort Study",
abstract = "Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.",
author = "JinHa Yoon and Park, {Jong Ku} and Oh, {Sung Soo} and Lee, {Ki Hyun} and Kim, {Sung Kyung} and Cho, {In Jung} and Kim, {Jong Koo} and Kang, {Hee Taik} and Ahn, {Sung Gyun} and Junwon Lee and Seunghwan Lee and Aeyong Eom and Kim, {Jang Young} and Songvogue Ahn and Sangbaek Koh",
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The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance : The Korean Genomic Rural Cohort Study. / Yoon, JinHa; Park, Jong Ku; Oh, Sung Soo; Lee, Ki Hyun; Kim, Sung Kyung; Cho, In Jung; Kim, Jong Koo; Kang, Hee Taik; Ahn, Sung Gyun; Lee, Junwon; Lee, Seunghwan; Eom, Aeyong; Kim, Jang Young; Ahn, Songvogue; Koh, Sangbaek.

In: Clinica Chimica Acta, Vol. 412, No. 23-24, 20.11.2011, p. 2199-2205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The ratio of serum leptin to adiponectin provides adjunctive information to the risk of metabolic syndrome beyond the homeostasis model assessment insulin resistance

T2 - The Korean Genomic Rural Cohort Study

AU - Yoon, JinHa

AU - Park, Jong Ku

AU - Oh, Sung Soo

AU - Lee, Ki Hyun

AU - Kim, Sung Kyung

AU - Cho, In Jung

AU - Kim, Jong Koo

AU - Kang, Hee Taik

AU - Ahn, Sung Gyun

AU - Lee, Junwon

AU - Lee, Seunghwan

AU - Eom, Aeyong

AU - Kim, Jang Young

AU - Ahn, Songvogue

AU - Koh, Sangbaek

PY - 2011/11/20

Y1 - 2011/11/20

N2 - Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.

AB - Background: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). Methods: This study included 1532 men and 1856 women, aged 40-70. y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. Results: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p< 0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). Conclusions: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.

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