The relationship between ambivalence, alexithymia, and salience network dysfunction in schizophrenia

Seon Koo Lee; Jung Suk Lee; Yu Bin Shin; Hesun Erin Kim; Byung Hoon Kim; Jae Jin Kim

doi:10.1016/j.pscychresns.2021.111271

The relationship between ambivalence, alexithymia, and salience network dysfunction in schizophrenia

Seon Koo Lee, Jung Suk Lee, Yu Bin Shin, Hesun Erin Kim, Byung Hoon Kim, Jae Jin Kim

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Ambivalence in schizophrenia is worth investigating its association with salience processing and alexithymia using functional MRI. Twenty-two patients with schizophrenia and 22 healthy controls were scanned during the ambivalence task of matching picture (ambivalent, positive and negative) and word (positive and negative) stimuli, and the Toronto Alexithymia Scale (TAS) was rated. Patients exhibited decreased activity in the anterior cingulate cortex (ACC) and insula compared to controls, and ACC activity in the ambivalent condition was negatively correlated with the TAS score in patients. Ambivalence in schizophrenia may be based on salience network dysfunction, and this disturbance may be related to alexithymia.

Original language	English
Article number	111271
Journal	Psychiatry Research - Neuroimaging
Volume	310
DOIs	https://doi.org/10.1016/j.pscychresns.2021.111271
Publication status	Published - 2021 Apr 30

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2016R1A2A2A10921744).

Publisher Copyright:
© 2021 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.pscychresns.2021.111271

Cite this

@article{380122cf8f674a378f78201b14fd7c0d,

title = "The relationship between ambivalence, alexithymia, and salience network dysfunction in schizophrenia",

abstract = "Ambivalence in schizophrenia is worth investigating its association with salience processing and alexithymia using functional MRI. Twenty-two patients with schizophrenia and 22 healthy controls were scanned during the ambivalence task of matching picture (ambivalent, positive and negative) and word (positive and negative) stimuli, and the Toronto Alexithymia Scale (TAS) was rated. Patients exhibited decreased activity in the anterior cingulate cortex (ACC) and insula compared to controls, and ACC activity in the ambivalent condition was negatively correlated with the TAS score in patients. Ambivalence in schizophrenia may be based on salience network dysfunction, and this disturbance may be related to alexithymia.",

author = "Lee, {Seon Koo} and Lee, {Jung Suk} and Shin, {Yu Bin} and Kim, {Hesun Erin} and Kim, {Byung Hoon} and Kim, {Jae Jin}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2016R1A2A2A10921744). Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = apr,

day = "30",

doi = "10.1016/j.pscychresns.2021.111271",

language = "English",

volume = "310",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - The relationship between ambivalence, alexithymia, and salience network dysfunction in schizophrenia

AU - Lee, Seon Koo

AU - Lee, Jung Suk

AU - Shin, Yu Bin

AU - Kim, Hesun Erin

AU - Kim, Byung Hoon

AU - Kim, Jae Jin

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2016R1A2A2A10921744). Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021/4/30

Y1 - 2021/4/30

N2 - Ambivalence in schizophrenia is worth investigating its association with salience processing and alexithymia using functional MRI. Twenty-two patients with schizophrenia and 22 healthy controls were scanned during the ambivalence task of matching picture (ambivalent, positive and negative) and word (positive and negative) stimuli, and the Toronto Alexithymia Scale (TAS) was rated. Patients exhibited decreased activity in the anterior cingulate cortex (ACC) and insula compared to controls, and ACC activity in the ambivalent condition was negatively correlated with the TAS score in patients. Ambivalence in schizophrenia may be based on salience network dysfunction, and this disturbance may be related to alexithymia.

AB - Ambivalence in schizophrenia is worth investigating its association with salience processing and alexithymia using functional MRI. Twenty-two patients with schizophrenia and 22 healthy controls were scanned during the ambivalence task of matching picture (ambivalent, positive and negative) and word (positive and negative) stimuli, and the Toronto Alexithymia Scale (TAS) was rated. Patients exhibited decreased activity in the anterior cingulate cortex (ACC) and insula compared to controls, and ACC activity in the ambivalent condition was negatively correlated with the TAS score in patients. Ambivalence in schizophrenia may be based on salience network dysfunction, and this disturbance may be related to alexithymia.

UR - http://www.scopus.com/inward/record.url?scp=85102127189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85102127189&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2021.111271

DO - 10.1016/j.pscychresns.2021.111271

M3 - Article

C2 - 33711658

AN - SCOPUS:85102127189

SN - 0925-4927

VL - 310

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

M1 - 111271

ER -

The relationship between ambivalence, alexithymia, and salience network dysfunction in schizophrenia

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this