The relationship between ambivalence, alexithymia, and salience network dysfunction in schizophrenia

Seon Koo Lee, Jung Suk Lee, Yu Bin Shin, Hesun Erin Kim, Byung Hoon Kim, Jae Jin Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Ambivalence in schizophrenia is worth investigating its association with salience processing and alexithymia using functional MRI. Twenty-two patients with schizophrenia and 22 healthy controls were scanned during the ambivalence task of matching picture (ambivalent, positive and negative) and word (positive and negative) stimuli, and the Toronto Alexithymia Scale (TAS) was rated. Patients exhibited decreased activity in the anterior cingulate cortex (ACC) and insula compared to controls, and ACC activity in the ambivalent condition was negatively correlated with the TAS score in patients. Ambivalence in schizophrenia may be based on salience network dysfunction, and this disturbance may be related to alexithymia.

Original languageEnglish
Article number111271
JournalPsychiatry Research - Neuroimaging
Publication statusPublished - 2021 Apr 30

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2016R1A2A2A10921744).

Publisher Copyright:
© 2021 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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