The relationship between arterial stiffness and nonalcoholic fatty liver disease

Yongjae Lee, Jae Yong Shim, Byung Soo Moon, Youn Ho Shin, Dong Hyuk Jung, Jung Hyun Lee, Hye Ree Lee

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Aim: Nonalcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease and some studies have documented its link with cardiovascular risk factors. This study aimed to investigate the association between arterial stiffness and NAFLD. Methods: Among 1,442 health check-up subjects (955 men, 487 women), we examined the association between brachial-ankle pulse wave velocity (baPWV) as a measurement of arterial stiffness and the presence of NAFLD based on abdominal sonographic findings. Multivariate linear and logistic regression analyses were conducted to examine the independent association between baPWV and the presence of NAFLD in gender-specific manners. Results: In multivariate regression analysis, NAFLD was found to be independently associated with baPWV in both men and women. Moreover, in multivariate logistic regression analysis, a graded independent relation was found between higher levels of baPWV and the prevalence risk of NAFLD. Odds ratios (95% CI) for the highest vs. the lowest quartile of baPWV were 1.85 (range, 1.13-2.62) in men and 3.32 (1.45-7.62) in women after adjusting for age, smoking status, regular exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, hypertension and diabetes. Conclusion: Arterial stiffness was independently associated with the prevalence risk for NAFLD regardless of classical CVD risk factors.

Original languageEnglish
Pages (from-to)196-203
Number of pages8
JournalDigestive Diseases and Sciences
Volume57
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Vascular Stiffness
Pulse Wave Analysis
Ankle
Arm
Regression Analysis
Logistic Models
Non-alcoholic Fatty Liver Disease
HDL Cholesterol
Liver Diseases
Linear Models
Fasting
Triglycerides
Body Mass Index
Chronic Disease
Multivariate Analysis
Smoking
Odds Ratio
Exercise
Blood Pressure
Hypertension

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Lee, Y., Shim, J. Y., Moon, B. S., Shin, Y. H., Jung, D. H., Lee, J. H., & Lee, H. R. (2012). The relationship between arterial stiffness and nonalcoholic fatty liver disease. Digestive Diseases and Sciences, 57(1), 196-203. https://doi.org/10.1007/s10620-011-1819-3
Lee, Yongjae ; Shim, Jae Yong ; Moon, Byung Soo ; Shin, Youn Ho ; Jung, Dong Hyuk ; Lee, Jung Hyun ; Lee, Hye Ree. / The relationship between arterial stiffness and nonalcoholic fatty liver disease. In: Digestive Diseases and Sciences. 2012 ; Vol. 57, No. 1. pp. 196-203.
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The relationship between arterial stiffness and nonalcoholic fatty liver disease. / Lee, Yongjae; Shim, Jae Yong; Moon, Byung Soo; Shin, Youn Ho; Jung, Dong Hyuk; Lee, Jung Hyun; Lee, Hye Ree.

In: Digestive Diseases and Sciences, Vol. 57, No. 1, 01.01.2012, p. 196-203.

Research output: Contribution to journalArticle

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