The relationship between brain morphometry and neuropsychological performance in alcohol dependence

Dong Pyo Jang, Kee Namkoong, Jae-Jin Kim, Sangjin Park, In Young Kim, Sun I. Kim, Young Bo Kim, Zang Hee Cho, Eun Lee

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The aim of this study was to explore local brain atrophy of patients with alcohol dependence using a voxel-based analysis of magnetic resonance images and to investigate the relationship of those atrophic regions with drinking history and neuropsychological performances. Statistical parametric mapping was applied for the global and regional comparison of segmented gray matter and white matter images from 20 patients with alcohol dependence and with those from 20 controls. The Rey auditory-verbal learning test, Rey-Osterrieth complex figure test, Stroop test, trail-making test, and Wisconsin card sorting test were conducted as neuropsychological evaluations. There was a significant decrease in both gray matter and white matter globally in alcohol dependence. Bilateral parahippocampal white matter areas were reduced in particular. Perseverative responses and perseverative errors in the Wisconsin card sorting test had significant correlation with the decrease of gray matter decrease including the left superior temporal gyri and right postcentral region. The psychological performance measures correlated with gray matter rather than white matter, whereas right temporal white matter correlated with drinking amount for last 4 weeks. This may imply that alcohol consumption in heavy amounts damages both gray matter and white matter, and gray matter atrophy mainly leads to cognitive impairment, whereas white matter is related to drinking history.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalNeuroscience Letters
Volume428
Issue number1
DOIs
Publication statusPublished - 2007 Nov 20

Fingerprint

Alcoholism
Brain
Drinking
Atrophy
Trail Making Test
Stroop Test
Verbal Learning
Temporal Lobe
White Matter
Alcohol Drinking
Gray Matter
Magnetic Resonance Spectroscopy
Psychology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Jang, Dong Pyo ; Namkoong, Kee ; Kim, Jae-Jin ; Park, Sangjin ; Kim, In Young ; Kim, Sun I. ; Kim, Young Bo ; Cho, Zang Hee ; Lee, Eun. / The relationship between brain morphometry and neuropsychological performance in alcohol dependence. In: Neuroscience Letters. 2007 ; Vol. 428, No. 1. pp. 21-26.
@article{b6ddf769e6b642bb9c99385d07b5766f,
title = "The relationship between brain morphometry and neuropsychological performance in alcohol dependence",
abstract = "The aim of this study was to explore local brain atrophy of patients with alcohol dependence using a voxel-based analysis of magnetic resonance images and to investigate the relationship of those atrophic regions with drinking history and neuropsychological performances. Statistical parametric mapping was applied for the global and regional comparison of segmented gray matter and white matter images from 20 patients with alcohol dependence and with those from 20 controls. The Rey auditory-verbal learning test, Rey-Osterrieth complex figure test, Stroop test, trail-making test, and Wisconsin card sorting test were conducted as neuropsychological evaluations. There was a significant decrease in both gray matter and white matter globally in alcohol dependence. Bilateral parahippocampal white matter areas were reduced in particular. Perseverative responses and perseverative errors in the Wisconsin card sorting test had significant correlation with the decrease of gray matter decrease including the left superior temporal gyri and right postcentral region. The psychological performance measures correlated with gray matter rather than white matter, whereas right temporal white matter correlated with drinking amount for last 4 weeks. This may imply that alcohol consumption in heavy amounts damages both gray matter and white matter, and gray matter atrophy mainly leads to cognitive impairment, whereas white matter is related to drinking history.",
author = "Jang, {Dong Pyo} and Kee Namkoong and Jae-Jin Kim and Sangjin Park and Kim, {In Young} and Kim, {Sun I.} and Kim, {Young Bo} and Cho, {Zang Hee} and Eun Lee",
year = "2007",
month = "11",
day = "20",
doi = "10.1016/j.neulet.2007.09.047",
language = "English",
volume = "428",
pages = "21--26",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Jang, DP, Namkoong, K, Kim, J-J, Park, S, Kim, IY, Kim, SI, Kim, YB, Cho, ZH & Lee, E 2007, 'The relationship between brain morphometry and neuropsychological performance in alcohol dependence', Neuroscience Letters, vol. 428, no. 1, pp. 21-26. https://doi.org/10.1016/j.neulet.2007.09.047

The relationship between brain morphometry and neuropsychological performance in alcohol dependence. / Jang, Dong Pyo; Namkoong, Kee; Kim, Jae-Jin; Park, Sangjin; Kim, In Young; Kim, Sun I.; Kim, Young Bo; Cho, Zang Hee; Lee, Eun.

In: Neuroscience Letters, Vol. 428, No. 1, 20.11.2007, p. 21-26.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The relationship between brain morphometry and neuropsychological performance in alcohol dependence

AU - Jang, Dong Pyo

AU - Namkoong, Kee

AU - Kim, Jae-Jin

AU - Park, Sangjin

AU - Kim, In Young

AU - Kim, Sun I.

AU - Kim, Young Bo

AU - Cho, Zang Hee

AU - Lee, Eun

PY - 2007/11/20

Y1 - 2007/11/20

N2 - The aim of this study was to explore local brain atrophy of patients with alcohol dependence using a voxel-based analysis of magnetic resonance images and to investigate the relationship of those atrophic regions with drinking history and neuropsychological performances. Statistical parametric mapping was applied for the global and regional comparison of segmented gray matter and white matter images from 20 patients with alcohol dependence and with those from 20 controls. The Rey auditory-verbal learning test, Rey-Osterrieth complex figure test, Stroop test, trail-making test, and Wisconsin card sorting test were conducted as neuropsychological evaluations. There was a significant decrease in both gray matter and white matter globally in alcohol dependence. Bilateral parahippocampal white matter areas were reduced in particular. Perseverative responses and perseverative errors in the Wisconsin card sorting test had significant correlation with the decrease of gray matter decrease including the left superior temporal gyri and right postcentral region. The psychological performance measures correlated with gray matter rather than white matter, whereas right temporal white matter correlated with drinking amount for last 4 weeks. This may imply that alcohol consumption in heavy amounts damages both gray matter and white matter, and gray matter atrophy mainly leads to cognitive impairment, whereas white matter is related to drinking history.

AB - The aim of this study was to explore local brain atrophy of patients with alcohol dependence using a voxel-based analysis of magnetic resonance images and to investigate the relationship of those atrophic regions with drinking history and neuropsychological performances. Statistical parametric mapping was applied for the global and regional comparison of segmented gray matter and white matter images from 20 patients with alcohol dependence and with those from 20 controls. The Rey auditory-verbal learning test, Rey-Osterrieth complex figure test, Stroop test, trail-making test, and Wisconsin card sorting test were conducted as neuropsychological evaluations. There was a significant decrease in both gray matter and white matter globally in alcohol dependence. Bilateral parahippocampal white matter areas were reduced in particular. Perseverative responses and perseverative errors in the Wisconsin card sorting test had significant correlation with the decrease of gray matter decrease including the left superior temporal gyri and right postcentral region. The psychological performance measures correlated with gray matter rather than white matter, whereas right temporal white matter correlated with drinking amount for last 4 weeks. This may imply that alcohol consumption in heavy amounts damages both gray matter and white matter, and gray matter atrophy mainly leads to cognitive impairment, whereas white matter is related to drinking history.

UR - http://www.scopus.com/inward/record.url?scp=35448962916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35448962916&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2007.09.047

DO - 10.1016/j.neulet.2007.09.047

M3 - Article

VL - 428

SP - 21

EP - 26

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -