The relationship between clinical characteristics including presence of exposed lesions and health-related quality of life (HRQoL) in patients with psoriasis: analysis from the nationwide epidemiologic study for psoriasis in Korea (EPI-PSODE study)

S. W. Youn, J. H. Lee, D. Y. Yu, Y. Kim, B. S. Kim, S. J. Seo, Y. B. Choe, S. K. Yun, J. Park, N. I. Kim, C. W. Choi, J. I. Youn, S. J. Lee, Mingeol Lee, K. J. Kim, C. J. Park, Y. S. Ro, H. J. Song, B. S. Shin, S. K. AhnJ. Y. Lee, Y. H. Won, M. S. Jang, K. H. Kim, M. H. Kim, T. Y. Kim, J. H. Choi

Research output: Contribution to journalArticle

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Abstract

Background: Psychological aspect and quality of life should be considered in treating patients with psoriasis. Objective: We sought to ascertain which clinical characteristics including presence of exposed lesions are associated with impairment of health-related quality of life (HRQoL) in patients with psoriasis. Methods: The EPI-PSODE study was a nationwide, multicenter, cross-sectional study conducted in Korea that included 1260 adult patients with psoriasis. In addition to clinical characteristics including presence of exposed lesions, data were collected using the Psoriatic Arthritis (PsA) Screening and Evaluation (PASE), Dermatology Life Quality Index (DLQI), MOS 36-Item Short-Form Health Survey (SF-36), Work Productivity and Activity Impairment Questionnaire Psoriasis (WPAI: PSO) and Medication Satisfaction Questionnaire (MSQ). Results: Patients with a DLQI score > 5 (n = 990) were younger, had an earlier onset of psoriasis, scored higher on the Psoriasis Area and Severity Index (PASI), had higher body surface area (BSA) and had higher PASE scores than patients with DLQI ≤ 5 (n = 266). The group of patients with exposed lesions (n = 871) were younger and male predominance, earlier onset of psoriasis, longer disease duration, higher PASI/BSA score and a higher proportion with drinking and smoking history each than the group of patients without exposed lesions (n = 389). Presence of exposed lesions negatively influenced DLQI, 36-Item Short-Form Health Survey (SF-36) (mental component), presenteeism, total work productivity impairment and total activity impairment in the WPAI: PSO. In multiple regression model, PASI score was the only variable which was significantly associated with all HRQoL measures. Presence of exposed lesions was a significant factor affecting DLQI and SF-36 (mental). Conclusion: The presence of exposed lesions has a negative impact on quality of life, mental health and work productivity. Therefore, effective treatments are particularly needed for psoriasis patients with exposed lesions.

Original languageEnglish
Pages (from-to)1499-1506
Number of pages8
JournalJournal of the European Academy of Dermatology and Venereology
Volume32
Issue number9
DOIs
Publication statusPublished - 2018 Sep 1

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Korea
Psoriasis
Epidemiologic Studies
Quality of Life
Dermatology
Efficiency
Body Surface Area
Health Surveys
Psoriatic Arthritis
Drinking
Mental Health
Cross-Sectional Studies
Smoking
History
Psychology

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

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Youn, S. W. ; Lee, J. H. ; Yu, D. Y. ; Kim, Y. ; Kim, B. S. ; Seo, S. J. ; Choe, Y. B. ; Yun, S. K. ; Park, J. ; Kim, N. I. ; Choi, C. W. ; Youn, J. I. ; Lee, S. J. ; Lee, Mingeol ; Kim, K. J. ; Park, C. J. ; Ro, Y. S. ; Song, H. J. ; Shin, B. S. ; Ahn, S. K. ; Lee, J. Y. ; Won, Y. H. ; Jang, M. S. ; Kim, K. H. ; Kim, M. H. ; Kim, T. Y. ; Choi, J. H. / The relationship between clinical characteristics including presence of exposed lesions and health-related quality of life (HRQoL) in patients with psoriasis : analysis from the nationwide epidemiologic study for psoriasis in Korea (EPI-PSODE study). In: Journal of the European Academy of Dermatology and Venereology. 2018 ; Vol. 32, No. 9. pp. 1499-1506.
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title = "The relationship between clinical characteristics including presence of exposed lesions and health-related quality of life (HRQoL) in patients with psoriasis: analysis from the nationwide epidemiologic study for psoriasis in Korea (EPI-PSODE study)",
abstract = "Background: Psychological aspect and quality of life should be considered in treating patients with psoriasis. Objective: We sought to ascertain which clinical characteristics including presence of exposed lesions are associated with impairment of health-related quality of life (HRQoL) in patients with psoriasis. Methods: The EPI-PSODE study was a nationwide, multicenter, cross-sectional study conducted in Korea that included 1260 adult patients with psoriasis. In addition to clinical characteristics including presence of exposed lesions, data were collected using the Psoriatic Arthritis (PsA) Screening and Evaluation (PASE), Dermatology Life Quality Index (DLQI), MOS 36-Item Short-Form Health Survey (SF-36), Work Productivity and Activity Impairment Questionnaire Psoriasis (WPAI: PSO) and Medication Satisfaction Questionnaire (MSQ). Results: Patients with a DLQI score > 5 (n = 990) were younger, had an earlier onset of psoriasis, scored higher on the Psoriasis Area and Severity Index (PASI), had higher body surface area (BSA) and had higher PASE scores than patients with DLQI ≤ 5 (n = 266). The group of patients with exposed lesions (n = 871) were younger and male predominance, earlier onset of psoriasis, longer disease duration, higher PASI/BSA score and a higher proportion with drinking and smoking history each than the group of patients without exposed lesions (n = 389). Presence of exposed lesions negatively influenced DLQI, 36-Item Short-Form Health Survey (SF-36) (mental component), presenteeism, total work productivity impairment and total activity impairment in the WPAI: PSO. In multiple regression model, PASI score was the only variable which was significantly associated with all HRQoL measures. Presence of exposed lesions was a significant factor affecting DLQI and SF-36 (mental). Conclusion: The presence of exposed lesions has a negative impact on quality of life, mental health and work productivity. Therefore, effective treatments are particularly needed for psoriasis patients with exposed lesions.",
author = "Youn, {S. W.} and Lee, {J. H.} and Yu, {D. Y.} and Y. Kim and Kim, {B. S.} and Seo, {S. J.} and Choe, {Y. B.} and Yun, {S. K.} and J. Park and Kim, {N. I.} and Choi, {C. W.} and Youn, {J. I.} and Lee, {S. J.} and Mingeol Lee and Kim, {K. J.} and Park, {C. J.} and Ro, {Y. S.} and Song, {H. J.} and Shin, {B. S.} and Ahn, {S. K.} and Lee, {J. Y.} and Won, {Y. H.} and Jang, {M. S.} and Kim, {K. H.} and Kim, {M. H.} and Kim, {T. Y.} and Choi, {J. H.}",
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Youn, SW, Lee, JH, Yu, DY, Kim, Y, Kim, BS, Seo, SJ, Choe, YB, Yun, SK, Park, J, Kim, NI, Choi, CW, Youn, JI, Lee, SJ, Lee, M, Kim, KJ, Park, CJ, Ro, YS, Song, HJ, Shin, BS, Ahn, SK, Lee, JY, Won, YH, Jang, MS, Kim, KH, Kim, MH, Kim, TY & Choi, JH 2018, 'The relationship between clinical characteristics including presence of exposed lesions and health-related quality of life (HRQoL) in patients with psoriasis: analysis from the nationwide epidemiologic study for psoriasis in Korea (EPI-PSODE study)', Journal of the European Academy of Dermatology and Venereology, vol. 32, no. 9, pp. 1499-1506. https://doi.org/10.1111/jdv.14865

The relationship between clinical characteristics including presence of exposed lesions and health-related quality of life (HRQoL) in patients with psoriasis : analysis from the nationwide epidemiologic study for psoriasis in Korea (EPI-PSODE study). / Youn, S. W.; Lee, J. H.; Yu, D. Y.; Kim, Y.; Kim, B. S.; Seo, S. J.; Choe, Y. B.; Yun, S. K.; Park, J.; Kim, N. I.; Choi, C. W.; Youn, J. I.; Lee, S. J.; Lee, Mingeol; Kim, K. J.; Park, C. J.; Ro, Y. S.; Song, H. J.; Shin, B. S.; Ahn, S. K.; Lee, J. Y.; Won, Y. H.; Jang, M. S.; Kim, K. H.; Kim, M. H.; Kim, T. Y.; Choi, J. H.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 32, No. 9, 01.09.2018, p. 1499-1506.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The relationship between clinical characteristics including presence of exposed lesions and health-related quality of life (HRQoL) in patients with psoriasis

T2 - analysis from the nationwide epidemiologic study for psoriasis in Korea (EPI-PSODE study)

AU - Youn, S. W.

AU - Lee, J. H.

AU - Yu, D. Y.

AU - Kim, Y.

AU - Kim, B. S.

AU - Seo, S. J.

AU - Choe, Y. B.

AU - Yun, S. K.

AU - Park, J.

AU - Kim, N. I.

AU - Choi, C. W.

AU - Youn, J. I.

AU - Lee, S. J.

AU - Lee, Mingeol

AU - Kim, K. J.

AU - Park, C. J.

AU - Ro, Y. S.

AU - Song, H. J.

AU - Shin, B. S.

AU - Ahn, S. K.

AU - Lee, J. Y.

AU - Won, Y. H.

AU - Jang, M. S.

AU - Kim, K. H.

AU - Kim, M. H.

AU - Kim, T. Y.

AU - Choi, J. H.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Psychological aspect and quality of life should be considered in treating patients with psoriasis. Objective: We sought to ascertain which clinical characteristics including presence of exposed lesions are associated with impairment of health-related quality of life (HRQoL) in patients with psoriasis. Methods: The EPI-PSODE study was a nationwide, multicenter, cross-sectional study conducted in Korea that included 1260 adult patients with psoriasis. In addition to clinical characteristics including presence of exposed lesions, data were collected using the Psoriatic Arthritis (PsA) Screening and Evaluation (PASE), Dermatology Life Quality Index (DLQI), MOS 36-Item Short-Form Health Survey (SF-36), Work Productivity and Activity Impairment Questionnaire Psoriasis (WPAI: PSO) and Medication Satisfaction Questionnaire (MSQ). Results: Patients with a DLQI score > 5 (n = 990) were younger, had an earlier onset of psoriasis, scored higher on the Psoriasis Area and Severity Index (PASI), had higher body surface area (BSA) and had higher PASE scores than patients with DLQI ≤ 5 (n = 266). The group of patients with exposed lesions (n = 871) were younger and male predominance, earlier onset of psoriasis, longer disease duration, higher PASI/BSA score and a higher proportion with drinking and smoking history each than the group of patients without exposed lesions (n = 389). Presence of exposed lesions negatively influenced DLQI, 36-Item Short-Form Health Survey (SF-36) (mental component), presenteeism, total work productivity impairment and total activity impairment in the WPAI: PSO. In multiple regression model, PASI score was the only variable which was significantly associated with all HRQoL measures. Presence of exposed lesions was a significant factor affecting DLQI and SF-36 (mental). Conclusion: The presence of exposed lesions has a negative impact on quality of life, mental health and work productivity. Therefore, effective treatments are particularly needed for psoriasis patients with exposed lesions.

AB - Background: Psychological aspect and quality of life should be considered in treating patients with psoriasis. Objective: We sought to ascertain which clinical characteristics including presence of exposed lesions are associated with impairment of health-related quality of life (HRQoL) in patients with psoriasis. Methods: The EPI-PSODE study was a nationwide, multicenter, cross-sectional study conducted in Korea that included 1260 adult patients with psoriasis. In addition to clinical characteristics including presence of exposed lesions, data were collected using the Psoriatic Arthritis (PsA) Screening and Evaluation (PASE), Dermatology Life Quality Index (DLQI), MOS 36-Item Short-Form Health Survey (SF-36), Work Productivity and Activity Impairment Questionnaire Psoriasis (WPAI: PSO) and Medication Satisfaction Questionnaire (MSQ). Results: Patients with a DLQI score > 5 (n = 990) were younger, had an earlier onset of psoriasis, scored higher on the Psoriasis Area and Severity Index (PASI), had higher body surface area (BSA) and had higher PASE scores than patients with DLQI ≤ 5 (n = 266). The group of patients with exposed lesions (n = 871) were younger and male predominance, earlier onset of psoriasis, longer disease duration, higher PASI/BSA score and a higher proportion with drinking and smoking history each than the group of patients without exposed lesions (n = 389). Presence of exposed lesions negatively influenced DLQI, 36-Item Short-Form Health Survey (SF-36) (mental component), presenteeism, total work productivity impairment and total activity impairment in the WPAI: PSO. In multiple regression model, PASI score was the only variable which was significantly associated with all HRQoL measures. Presence of exposed lesions was a significant factor affecting DLQI and SF-36 (mental). Conclusion: The presence of exposed lesions has a negative impact on quality of life, mental health and work productivity. Therefore, effective treatments are particularly needed for psoriasis patients with exposed lesions.

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