The relationship between gastric myoelectric activity and SCN5A mutation suggesting sodium channelopathy in patients with Brugada syndrome and functional dyspepsia - A pilot study

Kyo Tae Jung, Hyojin Park, Jie Hyun Kim, Dong Jik Shin, Bo Young Joung, Moon Hyoung Lee, Yang Soo Jang

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background/Aims: SCN5A encodes the cardiac-specific NaV1.5 sodium channel, and Brugada syndrome is a cardiac conduction disorder associated with sodium channel α-subunit (SCN5A) mutation. The SCN5A-encoded NaV1.5 channel is also found on gastrointestinal smooth muscle and interstitial cells of Cajal. We investigated the relationship between functional dyspepsia (FD) and SCN5A mutation to evaluate sodium channelopathy in FD. Methods: Patients with Brugada syndrome or FD were examined using upper endoscopy, electrogastrography (EGG), FD symptom questionnaire based on Rome III criteria and genetic testing for SCN5A mutation. Symptom scores of FD and EGG findings were analyzed according to SCN5A mutation. Results: A total of 17 patients (4 Brugada syndrome and 13 FD) participated in the study. An SCN5A mutation was noted in 75.0% of the patients with Brugada syndrome and in 1 (7.7%) of the patients with FD. Of 4 patients with SCN5A mutation, 2 (50%) had FD. Postprandial tachygastria and bradygastria were noted in 2 (50%) and 1 (25%) of the patients with SCN5A mutation, respectively. The EGG findings were not significantly different between positive and negative mutation in 17 patients. Conclusions: Although we did not find statistically significant results, we suggest that it is meaningful to attempt to identify differences in symptoms and gastric myoelectric activity according to the presence of an SCN5A mutation by EGG analysis. The relationship between FD and sodium channelopathy should be elucidated in the future by a large-scale study.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalJournal of Neurogastroenterology and Motility
Volume18
Issue number1
DOIs
Publication statusPublished - 2012 Jan

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Gastroenterology

Fingerprint Dive into the research topics of 'The relationship between gastric myoelectric activity and SCN5A mutation suggesting sodium channelopathy in patients with Brugada syndrome and functional dyspepsia - A pilot study'. Together they form a unique fingerprint.

Cite this