The Relationship between Hemodialysis Modality and Insulin Resistance in Non-Diabetic Hemodialysis Patients

Sung Jin Moon, Jung Eun Lee, Jwa Kyung Kim, Soo Young Yoon, Shin Wook Kang, Kyu Hun Choi, Sung Kyu Ha, Hyeong Cheon Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Although various modalities of hemodialysis (HD) are presumed to have different effects on insulin resistance (IR), the relationship between hemodiafiltration (HDF) and IR has not been fully evaluated. Methods: In a cross-sectional study, 82 non-diabetic HD patients were enrolled. The patients were divided into two groups according to the median homeostasis model assessment index (HOMA-IR) value of 1.685. Clinical and biochemical data were compared, and multivariate logistic regression analysis was performed to identify the independent factors associated with higher HOMA-IR. Results: The higher HOMA-IR group had increased body mass index (BMI), decreased HDL cholesterol, and lower beta-2 microglobulin reduction rate (β2-MG RR) compared to the lower HOMA-IR group. HOMA-IR was significantly correlated with β2-MG RR. In addition, HDF patients had lower HOMA-IR levels compared with low flux hemodialysis patients. On multivariate logistic regression analysis, BMI and HDF treatment were independent factors associated with higher and lower HOMA-IR, respectively. Conclusion: This study suggests that HDF treatment may reduce IR in non-diabetic HD patients.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalBlood Purification
Volume39
Issue number1-3
DOIs
Publication statusPublished - 2015 Jun 9

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Renal Dialysis
Insulin Resistance
Hemodiafiltration
Body Mass Index
Logistic Models
Regression Analysis
beta 2-Microglobulin
HDL Cholesterol
Homeostasis
Cross-Sectional Studies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Moon, Sung Jin ; Lee, Jung Eun ; Kim, Jwa Kyung ; Yoon, Soo Young ; Kang, Shin Wook ; Choi, Kyu Hun ; Ha, Sung Kyu ; Park, Hyeong Cheon. / The Relationship between Hemodialysis Modality and Insulin Resistance in Non-Diabetic Hemodialysis Patients. In: Blood Purification. 2015 ; Vol. 39, No. 1-3. pp. 224-229.
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The Relationship between Hemodialysis Modality and Insulin Resistance in Non-Diabetic Hemodialysis Patients. / Moon, Sung Jin; Lee, Jung Eun; Kim, Jwa Kyung; Yoon, Soo Young; Kang, Shin Wook; Choi, Kyu Hun; Ha, Sung Kyu; Park, Hyeong Cheon.

In: Blood Purification, Vol. 39, No. 1-3, 09.06.2015, p. 224-229.

Research output: Contribution to journalArticle

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AU - Choi, Kyu Hun

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N2 - Background: Although various modalities of hemodialysis (HD) are presumed to have different effects on insulin resistance (IR), the relationship between hemodiafiltration (HDF) and IR has not been fully evaluated. Methods: In a cross-sectional study, 82 non-diabetic HD patients were enrolled. The patients were divided into two groups according to the median homeostasis model assessment index (HOMA-IR) value of 1.685. Clinical and biochemical data were compared, and multivariate logistic regression analysis was performed to identify the independent factors associated with higher HOMA-IR. Results: The higher HOMA-IR group had increased body mass index (BMI), decreased HDL cholesterol, and lower beta-2 microglobulin reduction rate (β2-MG RR) compared to the lower HOMA-IR group. HOMA-IR was significantly correlated with β2-MG RR. In addition, HDF patients had lower HOMA-IR levels compared with low flux hemodialysis patients. On multivariate logistic regression analysis, BMI and HDF treatment were independent factors associated with higher and lower HOMA-IR, respectively. Conclusion: This study suggests that HDF treatment may reduce IR in non-diabetic HD patients.

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