The Relationship between Hemodialysis Modality and Insulin Resistance in Non-Diabetic Hemodialysis Patients

Sung Jin Moon, Jung Eun Lee, Jwa Kyung Kim, Soo Young Yoon, Shin Wook Kang, Kyu Hun Choi, Sung Kyu Ha, Hyeong Cheon Park

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Abstract

Background: Although various modalities of hemodialysis (HD) are presumed to have different effects on insulin resistance (IR), the relationship between hemodiafiltration (HDF) and IR has not been fully evaluated. Methods: In a cross-sectional study, 82 non-diabetic HD patients were enrolled. The patients were divided into two groups according to the median homeostasis model assessment index (HOMA-IR) value of 1.685. Clinical and biochemical data were compared, and multivariate logistic regression analysis was performed to identify the independent factors associated with higher HOMA-IR. Results: The higher HOMA-IR group had increased body mass index (BMI), decreased HDL cholesterol, and lower beta-2 microglobulin reduction rate (β2-MG RR) compared to the lower HOMA-IR group. HOMA-IR was significantly correlated with β2-MG RR. In addition, HDF patients had lower HOMA-IR levels compared with low flux hemodialysis patients. On multivariate logistic regression analysis, BMI and HDF treatment were independent factors associated with higher and lower HOMA-IR, respectively. Conclusion: This study suggests that HDF treatment may reduce IR in non-diabetic HD patients.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalBlood Purification
Volume39
Issue number1-3
DOIs
Publication statusPublished - 2015 Jun 9

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All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Moon, S. J., Lee, J. E., Kim, J. K., Yoon, S. Y., Kang, S. W., Choi, K. H., Ha, S. K., & Park, H. C. (2015). The Relationship between Hemodialysis Modality and Insulin Resistance in Non-Diabetic Hemodialysis Patients. Blood Purification, 39(1-3), 224-229. https://doi.org/10.1159/000368882