The relationship between the early follow-up BNP level and congestive status or prognosis in acute heart failure

Il Hyung Chung, Byungsu Yoo, Ho Yoel Ryu, Hee Sung Wang, Hyun Min Choi, Jang Young Kim, Seunghwan Lee, Sung Oh Hwang, Junghan Yoon, Kyung Hoon Choe

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: A correlation between the BNP reduction ratio and prognosis could be expected to be found by evaluating the BNP reduction depending on the volume status during the early period. Subjects and Methods: Between October 2002 and June 2004, 120 patients with acute heart failure (AHF) (<1 month) were included. The patients were divided into three groups according to their volume status, as follows. Group I: patients with clinical & radiological wet status, Group II: clinical dry & radiological wet status and Group III: clinical &. radiological dry status. The blood BNP (Triage®) level and clinical parameters were analyzed. The bad prognostic parameters were defined as readmission due to heart failure, a major adverse cardiac event or cardiovascular death. Results: The mean patient age was 68.0±12.7 years, and 50.0% of the subjects were male. The most frequent etiology of AHF was ischemic heart disease (35.8%). There were 61.7, 24.1 and 14.2% in Groups I, III and III, respectively. The baseline BNP level was higher in group I and II than in group III patients (I: 1540.4±1202.8, II: 1482.8±1281.6, III: 666.4±827.9 pg/mL, p=0.036) as was the early BNP reduction ratio (I: 69.8±27.1, II: 67.4±32.8, III: 1.3±144.9%, p=0.007). Sixteen (13.3%) patients had a poor prognosis. From a logistical analysis, the early BNP reduction ratio (p=0.004) and creatinine level (p=0.029) were significant predictors of the clinical outcomes. Conclusion: The early change in the BNP level varied depending on the degree of congestive status, and was also correlated with the level of clinical outcomes. Therefore, in our opinion, the early monitoring of the BNP level will provide significant clinical information in AHF patients.

Original languageEnglish
Pages (from-to)200-207
Number of pages8
JournalKorean Circulation Journal
Volume36
Issue number3
DOIs
Publication statusPublished - 2006 Jan 1

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Heart Failure
Triage
Myocardial Ischemia
Creatinine

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Chung, Il Hyung ; Yoo, Byungsu ; Ryu, Ho Yoel ; Wang, Hee Sung ; Choi, Hyun Min ; Kim, Jang Young ; Lee, Seunghwan ; Hwang, Sung Oh ; Yoon, Junghan ; Choe, Kyung Hoon. / The relationship between the early follow-up BNP level and congestive status or prognosis in acute heart failure. In: Korean Circulation Journal. 2006 ; Vol. 36, No. 3. pp. 200-207.
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abstract = "Background and Objectives: A correlation between the BNP reduction ratio and prognosis could be expected to be found by evaluating the BNP reduction depending on the volume status during the early period. Subjects and Methods: Between October 2002 and June 2004, 120 patients with acute heart failure (AHF) (<1 month) were included. The patients were divided into three groups according to their volume status, as follows. Group I: patients with clinical & radiological wet status, Group II: clinical dry & radiological wet status and Group III: clinical &. radiological dry status. The blood BNP (Triage{\circledR}) level and clinical parameters were analyzed. The bad prognostic parameters were defined as readmission due to heart failure, a major adverse cardiac event or cardiovascular death. Results: The mean patient age was 68.0±12.7 years, and 50.0{\%} of the subjects were male. The most frequent etiology of AHF was ischemic heart disease (35.8{\%}). There were 61.7, 24.1 and 14.2{\%} in Groups I, III and III, respectively. The baseline BNP level was higher in group I and II than in group III patients (I: 1540.4±1202.8, II: 1482.8±1281.6, III: 666.4±827.9 pg/mL, p=0.036) as was the early BNP reduction ratio (I: 69.8±27.1, II: 67.4±32.8, III: 1.3±144.9{\%}, p=0.007). Sixteen (13.3{\%}) patients had a poor prognosis. From a logistical analysis, the early BNP reduction ratio (p=0.004) and creatinine level (p=0.029) were significant predictors of the clinical outcomes. Conclusion: The early change in the BNP level varied depending on the degree of congestive status, and was also correlated with the level of clinical outcomes. Therefore, in our opinion, the early monitoring of the BNP level will provide significant clinical information in AHF patients.",
author = "Chung, {Il Hyung} and Byungsu Yoo and Ryu, {Ho Yoel} and Wang, {Hee Sung} and Choi, {Hyun Min} and Kim, {Jang Young} and Seunghwan Lee and Hwang, {Sung Oh} and Junghan Yoon and Choe, {Kyung Hoon}",
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The relationship between the early follow-up BNP level and congestive status or prognosis in acute heart failure. / Chung, Il Hyung; Yoo, Byungsu; Ryu, Ho Yoel; Wang, Hee Sung; Choi, Hyun Min; Kim, Jang Young; Lee, Seunghwan; Hwang, Sung Oh; Yoon, Junghan; Choe, Kyung Hoon.

In: Korean Circulation Journal, Vol. 36, No. 3, 01.01.2006, p. 200-207.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The relationship between the early follow-up BNP level and congestive status or prognosis in acute heart failure

AU - Chung, Il Hyung

AU - Yoo, Byungsu

AU - Ryu, Ho Yoel

AU - Wang, Hee Sung

AU - Choi, Hyun Min

AU - Kim, Jang Young

AU - Lee, Seunghwan

AU - Hwang, Sung Oh

AU - Yoon, Junghan

AU - Choe, Kyung Hoon

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background and Objectives: A correlation between the BNP reduction ratio and prognosis could be expected to be found by evaluating the BNP reduction depending on the volume status during the early period. Subjects and Methods: Between October 2002 and June 2004, 120 patients with acute heart failure (AHF) (<1 month) were included. The patients were divided into three groups according to their volume status, as follows. Group I: patients with clinical & radiological wet status, Group II: clinical dry & radiological wet status and Group III: clinical &. radiological dry status. The blood BNP (Triage®) level and clinical parameters were analyzed. The bad prognostic parameters were defined as readmission due to heart failure, a major adverse cardiac event or cardiovascular death. Results: The mean patient age was 68.0±12.7 years, and 50.0% of the subjects were male. The most frequent etiology of AHF was ischemic heart disease (35.8%). There were 61.7, 24.1 and 14.2% in Groups I, III and III, respectively. The baseline BNP level was higher in group I and II than in group III patients (I: 1540.4±1202.8, II: 1482.8±1281.6, III: 666.4±827.9 pg/mL, p=0.036) as was the early BNP reduction ratio (I: 69.8±27.1, II: 67.4±32.8, III: 1.3±144.9%, p=0.007). Sixteen (13.3%) patients had a poor prognosis. From a logistical analysis, the early BNP reduction ratio (p=0.004) and creatinine level (p=0.029) were significant predictors of the clinical outcomes. Conclusion: The early change in the BNP level varied depending on the degree of congestive status, and was also correlated with the level of clinical outcomes. Therefore, in our opinion, the early monitoring of the BNP level will provide significant clinical information in AHF patients.

AB - Background and Objectives: A correlation between the BNP reduction ratio and prognosis could be expected to be found by evaluating the BNP reduction depending on the volume status during the early period. Subjects and Methods: Between October 2002 and June 2004, 120 patients with acute heart failure (AHF) (<1 month) were included. The patients were divided into three groups according to their volume status, as follows. Group I: patients with clinical & radiological wet status, Group II: clinical dry & radiological wet status and Group III: clinical &. radiological dry status. The blood BNP (Triage®) level and clinical parameters were analyzed. The bad prognostic parameters were defined as readmission due to heart failure, a major adverse cardiac event or cardiovascular death. Results: The mean patient age was 68.0±12.7 years, and 50.0% of the subjects were male. The most frequent etiology of AHF was ischemic heart disease (35.8%). There were 61.7, 24.1 and 14.2% in Groups I, III and III, respectively. The baseline BNP level was higher in group I and II than in group III patients (I: 1540.4±1202.8, II: 1482.8±1281.6, III: 666.4±827.9 pg/mL, p=0.036) as was the early BNP reduction ratio (I: 69.8±27.1, II: 67.4±32.8, III: 1.3±144.9%, p=0.007). Sixteen (13.3%) patients had a poor prognosis. From a logistical analysis, the early BNP reduction ratio (p=0.004) and creatinine level (p=0.029) were significant predictors of the clinical outcomes. Conclusion: The early change in the BNP level varied depending on the degree of congestive status, and was also correlated with the level of clinical outcomes. Therefore, in our opinion, the early monitoring of the BNP level will provide significant clinical information in AHF patients.

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