The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter

Hye Won Lee; Kwang Joon Kim; Kyu Sik Jung; Young Eun Chon; Ji Hye Huh; Kyeong Hye Park; Jae Bock Chung; Chang Oh Kim; Kwang Hyub Han; Jun Yong Park

doi:10.1371/journal.pone.0187066

The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter

Hye Won Lee, Kwang Joon Kim, Kyu Sik Jung, Young Eun Chon, Ji Hye Huh, Kyeong Hye Park, Jae Bock Chung, Chang Oh Kim, Kwang Hyub Han, Jun Yong Park

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. Methods: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. Results: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912–8.039) for 100<VFA≤200 cm² and 7.474 (P<0.001; 95% CI, 2.462–22.693) for VFA >200 cm², compared to patients with a VFA ≤100 cm². Conclusions: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.

Original language	English
Article number	e0187066
Journal	PloS one
Volume	12
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0187066
Publication status	Published - 2017 Oct

Bibliographical note

Publisher Copyright:
© 2017 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

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@article{624bf83c64914895a9959434cb571c01,

title = "The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter",

abstract = "Background: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. Methods: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. Results: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912–8.039) for 100<VFA≤200 cm2 and 7.474 (P<0.001; 95% CI, 2.462–22.693) for VFA >200 cm2, compared to patients with a VFA ≤100 cm2. Conclusions: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.",

author = "Lee, {Hye Won} and Kim, {Kwang Joon} and Jung, {Kyu Sik} and Chon, {Young Eun} and Huh, {Ji Hye} and Park, {Kyeong Hye} and Chung, {Jae Bock} and Kim, {Chang Oh} and Han, {Kwang Hyub} and Park, {Jun Yong}",

note = "Publisher Copyright: {\textcopyright} 2017 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2017",

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The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter. / Lee, Hye Won; Kim, Kwang Joon; Jung, Kyu Sik; Chon, Young Eun; Huh, Ji Hye; Park, Kyeong Hye; Chung, Jae Bock; Kim, Chang Oh; Han, Kwang Hyub ; Park, Jun Yong.

In: PloS one, Vol. 12, No. 10, e0187066, 10.2017.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter

AU - Lee, Hye Won

AU - Kim, Kwang Joon

AU - Jung, Kyu Sik

AU - Chon, Young Eun

AU - Huh, Ji Hye

AU - Park, Kyeong Hye

AU - Chung, Jae Bock

AU - Kim, Chang Oh

AU - Han, Kwang Hyub

AU - Park, Jun Yong

N1 - Publisher Copyright: © 2017 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2017/10

Y1 - 2017/10

N2 - Background: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. Methods: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. Results: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912–8.039) for 100<VFA≤200 cm2 and 7.474 (P<0.001; 95% CI, 2.462–22.693) for VFA >200 cm2, compared to patients with a VFA ≤100 cm2. Conclusions: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.

AB - Background: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. Methods: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. Results: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912–8.039) for 100<VFA≤200 cm2 and 7.474 (P<0.001; 95% CI, 2.462–22.693) for VFA >200 cm2, compared to patients with a VFA ≤100 cm2. Conclusions: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.

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The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter

Abstract

Bibliographical note

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