The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients

P. W. Roche, W. J. Britton, K. Dev Neupane, S. S. Failbus, S. N. Cho, W. J. Theuvenet

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5 Citations (Scopus)

Abstract

We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.

Original languageEnglish
Pages (from-to)702-708
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume44
Issue number6
DOIs
Publication statusPublished - 1991 Jan 1

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

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