The role of a whole blood interferon-γ assay for the detection of latent tuberculosis infection in Bacille Calmette-Guérin vaccinated children

Jin Kyong Chun, Chang Ki Kim, Hyon Suk Kim, Ghee Young Jung, Taek Jin Lee, Ki Hwan Kim, Dong Soo Kim

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The tuberculin skin test (TST) has limitations in children who are under the Bacille Calmette-Guérin (BCG) effect. Our aim was to evaluate the QuantiFERON®-TB Gold In-Tube (QFT-G IT) blood test for Mycobacterium tuberculosis infection in children and to compare results with those of the TST. QFT-G IT and TST data were collected from 227 children between 0 and 15 years of age, split into 4 risk groups. Forty-two children were close contacts, 29 were casual contacts, and 65 were controls. The QFT-G IT positivity rates were 19% (8/42), 6.9% (2/29), and 1.5% (1/65), with a significantly higher rate for the close contacts over the controls (P < 0.05). The high specificity of the QFT-G IT assay and the association of positive results with increasing risk of infection in our study suggest it has major benefits over the TST as a screening test for latent infection with M. tuberculosis in BCG-vaccinated children.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume62
Issue number4
DOIs
Publication statusPublished - 2008 Dec 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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