The role of BMP4 in HERS during tooth root development

Hansung Jung, Akihiro Hosoya, Ji Youn Kim, Sung Won Cho

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Tooth development is regulated by reciprocal interactions between epithelial and mesenchymal cells. Several morphological studies suggest that growth factors secreted from these cells regulate tooth development. These growth factors induce undifferentiated cells in the tooth germ to differentiate into tooth-forming cells. Many growth factors are reportedly expressed in the developing tooth, but the key molecule underlying tooth root development is still unknown. There is a considerable amount of data on the expression and function of bone morphogenetic proteins (BMPs) during tooth development, but the relationship between BMPs and tooth root development has not been analyzed extensively. This prompted us to examine the expression patterns of BMP4 and BMP receptors (BMPRs) at the apical region of the tooth germ during mouse tooth root development. We found that BMP4 was strictly expressed in the apical mesenchyme, and that BMPRs were localized in Hertwig's epithelial root sheath (HERS). We also investigated the possible roles of BMP4 in HERS during the early stage of tooth root development. Our organ-culture results indicated that BMP4 regulates HERS formation via harmonious interactions with its own antagonist, noggin, by preventing elongation and maintaining cell proliferation. BMP4 may therefore be useful in various tissue-engineering applications as a regulator of tooth root formation.

Original languageEnglish
Pages (from-to)160-166
Number of pages7
JournalJournal of Oral Biosciences
Volume50
Issue number3
DOIs
Publication statusPublished - 2008 Jan 1

Fingerprint

Tooth Root
Bone Morphogenetic Protein Receptors
Intercellular Signaling Peptides and Proteins
Tooth
Bone Morphogenetic Proteins
Tooth Germ
Cell proliferation
Tissue engineering
Elongation
Organ Culture Techniques
Mesoderm
Tissue Engineering
Molecules
Epithelial Cells
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jung, Hansung ; Hosoya, Akihiro ; Kim, Ji Youn ; Cho, Sung Won. / The role of BMP4 in HERS during tooth root development. In: Journal of Oral Biosciences. 2008 ; Vol. 50, No. 3. pp. 160-166.
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The role of BMP4 in HERS during tooth root development. / Jung, Hansung; Hosoya, Akihiro; Kim, Ji Youn; Cho, Sung Won.

In: Journal of Oral Biosciences, Vol. 50, No. 3, 01.01.2008, p. 160-166.

Research output: Contribution to journalReview article

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AB - Tooth development is regulated by reciprocal interactions between epithelial and mesenchymal cells. Several morphological studies suggest that growth factors secreted from these cells regulate tooth development. These growth factors induce undifferentiated cells in the tooth germ to differentiate into tooth-forming cells. Many growth factors are reportedly expressed in the developing tooth, but the key molecule underlying tooth root development is still unknown. There is a considerable amount of data on the expression and function of bone morphogenetic proteins (BMPs) during tooth development, but the relationship between BMPs and tooth root development has not been analyzed extensively. This prompted us to examine the expression patterns of BMP4 and BMP receptors (BMPRs) at the apical region of the tooth germ during mouse tooth root development. We found that BMP4 was strictly expressed in the apical mesenchyme, and that BMPRs were localized in Hertwig's epithelial root sheath (HERS). We also investigated the possible roles of BMP4 in HERS during the early stage of tooth root development. Our organ-culture results indicated that BMP4 regulates HERS formation via harmonious interactions with its own antagonist, noggin, by preventing elongation and maintaining cell proliferation. BMP4 may therefore be useful in various tissue-engineering applications as a regulator of tooth root formation.

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