The role of hippo pathway in cancer stem cell biology

Jae Hyung Park, Ji Eun Shin, Hyun Woo Park

Research output: Contribution to journalShort survey

31 Citations (Scopus)

Abstract

The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalMolecules and cells
Volume41
Issue number2
DOIs
Publication statusPublished - 2018 Jan 1

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Neoplastic Stem Cells
Cell Biology
Organ Size
Drug Resistance
Neoplasms
Carcinogenesis
Phosphotransferases
Cell Proliferation
Growth
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Park, Jae Hyung ; Shin, Ji Eun ; Park, Hyun Woo. / The role of hippo pathway in cancer stem cell biology. In: Molecules and cells. 2018 ; Vol. 41, No. 2. pp. 83-92.
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The role of hippo pathway in cancer stem cell biology. / Park, Jae Hyung; Shin, Ji Eun; Park, Hyun Woo.

In: Molecules and cells, Vol. 41, No. 2, 01.01.2018, p. 83-92.

Research output: Contribution to journalShort survey

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