The role of insulin resistance in Korean patients with coronary atherosclerosis

Kap Bum Huh, Hyun Chul Lee, Seung Yun Cho, Jong Ho Lee, Young Duk Song

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To determine whether dietary modification improves insulin resistance and coronary atherosclerosis, we randomly assigned 14 Korean patients to an experimental group (low-fat, low-cholesterol diet, high polyunsaturated/saturated fatty acid ratio, and calorie restriction) or to a control group (no dietary change). Coronary artery lesions were analyzed by quantitative coronary angiography, and postglucose insulin responses were measured. At baseline, there were no significant differences in body weight, BMI, waist-to-hip ratio (WHR), and plasma lipid and insulin levels between the two groups. After completion of the 1-year diet program, the experimental group showed significant reductions in body weight (66.0 ± 3.2 to 61.6 ± 3.8 kg [means ± SE], P < 0.01) and WHR (0.96 ± 0.01 to 0.93 ± 0.01, P < 0.05). Total cholesterol (5.45 ± 0.45 to 4.50 ± 0.44 mmol/l, P < 0.05), LDL cholesterol (3.71 ± 0.36 to 2.98 ± 0.37 mmol/l, P < 0.05), and triglyceride (1.91 ± 0.28 to 1.29±0.17 mmol/l, P < 0.05) were also significantly reduced in the experimental group. The mean insulin response during an oral glucose tolerance test was also significantly decreased (258.6 ± 26.4 to 181.8 ± 6.6 pmol/l, P < 0.05). In contrast, there were no significant changes in these parameters in the control group. When only coronary artery lesions >50% stenosed were analyzed, the average percentage diameter stenosis regressed from 63.2 to 56.8% in the experimental group. However, there were no significant changes in the control group. Our trial suggests that decreases in body weight and WHR and an improvement in insulin resistance with a low-fat, low-cholesterol diet and caloric restriction may reduce risk factors and reverse coronary atherosclerotic lesions in 1 year.

Original languageEnglish
JournalDiabetes
Volume45
Issue number3 SUPPL.
Publication statusPublished - 1996 Dec 1

Fingerprint

Insulin Resistance
Coronary Artery Disease
Fat-Restricted Diet
Waist-Hip Ratio
Body Weight
Cholesterol
Insulin
Diet Therapy
Caloric Restriction
Control Groups
Coronary Angiography
Unsaturated Fatty Acids
Coronary Vessels
Pathologic Constriction
Fatty Acids
Diet
Lipids

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Huh, K. B., Lee, H. C., Cho, S. Y., Lee, J. H., & Song, Y. D. (1996). The role of insulin resistance in Korean patients with coronary atherosclerosis. Diabetes, 45(3 SUPPL.).
Huh, Kap Bum ; Lee, Hyun Chul ; Cho, Seung Yun ; Lee, Jong Ho ; Song, Young Duk. / The role of insulin resistance in Korean patients with coronary atherosclerosis. In: Diabetes. 1996 ; Vol. 45, No. 3 SUPPL.
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abstract = "To determine whether dietary modification improves insulin resistance and coronary atherosclerosis, we randomly assigned 14 Korean patients to an experimental group (low-fat, low-cholesterol diet, high polyunsaturated/saturated fatty acid ratio, and calorie restriction) or to a control group (no dietary change). Coronary artery lesions were analyzed by quantitative coronary angiography, and postglucose insulin responses were measured. At baseline, there were no significant differences in body weight, BMI, waist-to-hip ratio (WHR), and plasma lipid and insulin levels between the two groups. After completion of the 1-year diet program, the experimental group showed significant reductions in body weight (66.0 ± 3.2 to 61.6 ± 3.8 kg [means ± SE], P < 0.01) and WHR (0.96 ± 0.01 to 0.93 ± 0.01, P < 0.05). Total cholesterol (5.45 ± 0.45 to 4.50 ± 0.44 mmol/l, P < 0.05), LDL cholesterol (3.71 ± 0.36 to 2.98 ± 0.37 mmol/l, P < 0.05), and triglyceride (1.91 ± 0.28 to 1.29±0.17 mmol/l, P < 0.05) were also significantly reduced in the experimental group. The mean insulin response during an oral glucose tolerance test was also significantly decreased (258.6 ± 26.4 to 181.8 ± 6.6 pmol/l, P < 0.05). In contrast, there were no significant changes in these parameters in the control group. When only coronary artery lesions >50{\%} stenosed were analyzed, the average percentage diameter stenosis regressed from 63.2 to 56.8{\%} in the experimental group. However, there were no significant changes in the control group. Our trial suggests that decreases in body weight and WHR and an improvement in insulin resistance with a low-fat, low-cholesterol diet and caloric restriction may reduce risk factors and reverse coronary atherosclerotic lesions in 1 year.",
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Huh, KB, Lee, HC, Cho, SY, Lee, JH & Song, YD 1996, 'The role of insulin resistance in Korean patients with coronary atherosclerosis', Diabetes, vol. 45, no. 3 SUPPL..

The role of insulin resistance in Korean patients with coronary atherosclerosis. / Huh, Kap Bum; Lee, Hyun Chul; Cho, Seung Yun; Lee, Jong Ho; Song, Young Duk.

In: Diabetes, Vol. 45, No. 3 SUPPL., 01.12.1996.

Research output: Contribution to journalArticle

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T1 - The role of insulin resistance in Korean patients with coronary atherosclerosis

AU - Huh, Kap Bum

AU - Lee, Hyun Chul

AU - Cho, Seung Yun

AU - Lee, Jong Ho

AU - Song, Young Duk

PY - 1996/12/1

Y1 - 1996/12/1

N2 - To determine whether dietary modification improves insulin resistance and coronary atherosclerosis, we randomly assigned 14 Korean patients to an experimental group (low-fat, low-cholesterol diet, high polyunsaturated/saturated fatty acid ratio, and calorie restriction) or to a control group (no dietary change). Coronary artery lesions were analyzed by quantitative coronary angiography, and postglucose insulin responses were measured. At baseline, there were no significant differences in body weight, BMI, waist-to-hip ratio (WHR), and plasma lipid and insulin levels between the two groups. After completion of the 1-year diet program, the experimental group showed significant reductions in body weight (66.0 ± 3.2 to 61.6 ± 3.8 kg [means ± SE], P < 0.01) and WHR (0.96 ± 0.01 to 0.93 ± 0.01, P < 0.05). Total cholesterol (5.45 ± 0.45 to 4.50 ± 0.44 mmol/l, P < 0.05), LDL cholesterol (3.71 ± 0.36 to 2.98 ± 0.37 mmol/l, P < 0.05), and triglyceride (1.91 ± 0.28 to 1.29±0.17 mmol/l, P < 0.05) were also significantly reduced in the experimental group. The mean insulin response during an oral glucose tolerance test was also significantly decreased (258.6 ± 26.4 to 181.8 ± 6.6 pmol/l, P < 0.05). In contrast, there were no significant changes in these parameters in the control group. When only coronary artery lesions >50% stenosed were analyzed, the average percentage diameter stenosis regressed from 63.2 to 56.8% in the experimental group. However, there were no significant changes in the control group. Our trial suggests that decreases in body weight and WHR and an improvement in insulin resistance with a low-fat, low-cholesterol diet and caloric restriction may reduce risk factors and reverse coronary atherosclerotic lesions in 1 year.

AB - To determine whether dietary modification improves insulin resistance and coronary atherosclerosis, we randomly assigned 14 Korean patients to an experimental group (low-fat, low-cholesterol diet, high polyunsaturated/saturated fatty acid ratio, and calorie restriction) or to a control group (no dietary change). Coronary artery lesions were analyzed by quantitative coronary angiography, and postglucose insulin responses were measured. At baseline, there were no significant differences in body weight, BMI, waist-to-hip ratio (WHR), and plasma lipid and insulin levels between the two groups. After completion of the 1-year diet program, the experimental group showed significant reductions in body weight (66.0 ± 3.2 to 61.6 ± 3.8 kg [means ± SE], P < 0.01) and WHR (0.96 ± 0.01 to 0.93 ± 0.01, P < 0.05). Total cholesterol (5.45 ± 0.45 to 4.50 ± 0.44 mmol/l, P < 0.05), LDL cholesterol (3.71 ± 0.36 to 2.98 ± 0.37 mmol/l, P < 0.05), and triglyceride (1.91 ± 0.28 to 1.29±0.17 mmol/l, P < 0.05) were also significantly reduced in the experimental group. The mean insulin response during an oral glucose tolerance test was also significantly decreased (258.6 ± 26.4 to 181.8 ± 6.6 pmol/l, P < 0.05). In contrast, there were no significant changes in these parameters in the control group. When only coronary artery lesions >50% stenosed were analyzed, the average percentage diameter stenosis regressed from 63.2 to 56.8% in the experimental group. However, there were no significant changes in the control group. Our trial suggests that decreases in body weight and WHR and an improvement in insulin resistance with a low-fat, low-cholesterol diet and caloric restriction may reduce risk factors and reverse coronary atherosclerotic lesions in 1 year.

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