We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator - activated receptor γ(PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.
|Number of pages||5|
|Journal||Annals of the New York Academy of Sciences|
|Publication status||Published - 2002|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science