The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells

Tae Il Kim, Soo Hyun Jin, Eun Hye Kang, Sung Kwan Shin, Kang-Yell Choi, Won Ho Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator - activated receptor γ(PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume973
DOIs
Publication statusPublished - 2002 Jan 1

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Peroxisome Proliferator-Activated Receptors
Mitogen-Activated Protein Kinases
Indomethacin
Colonic Neoplasms
Cells
Apoptosis
p38 Mitogen-Activated Protein Kinases
Chemical activation
Caspases
Protein
Cancer
Cell Line
Activation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

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abstract = "We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator - activated receptor γ(PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.",
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The role of mitogen-activated protein kinases and their relationship with NF-κB and PPARγ in indomethacin-induced apoptosis of colon cancer cells. / Kim, Tae Il; Jin, Soo Hyun; Kang, Eun Hye; Shin, Sung Kwan; Choi, Kang-Yell; Kim, Won Ho.

In: Annals of the New York Academy of Sciences, Vol. 973, 01.01.2002, p. 241-245.

Research output: Contribution to journalArticle

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