The role of nacreous factors in preventing osteoporotic bone loss through both osteoblast activation and osteoclast inactivation

Hyunsoo Kim, Kyunghee Lee, Chang Yong Ko, Han Sung Kim, Hong In Shin, Taesoo Kim, Seoung Hoon Lee, Daewon Jeong

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Excessive bone resorption by osteoclasts relative to bone formation by osteoblasts results in the development of osteoporosis. Anti-osteoporotic agents that are able both to inhibit bone resorption and to stimulate bone formation are not available. We now show that water-soluble nacreous factors prepared from the pearl oyster Pteria martensii prevent osteoporotic bone loss associated with estrogen deficiency in mice mainly through osteoclast inactivation. Nacreous factors stimulated osteoblast biomineralization in vitro in association with activation of signaling by c-Jun NH2-terminal kinase (JNK) and Fos-related antigen-1 (Fra-1). They also suppressed both osteoclast formation by blocking up-regulation of nuclear factor of activated T cells cytoplasmic 1 (NFATc1) as well as bone pit formation mediated by mature osteoclasts, likely by disrupting the actin ring of these cells. Our findings thus show that the components of a natural material have beneficial effects on bone remodeling that are mediated through regulation of both osteoblast and osteoclast function. They may thus provide a basis for the development of biomimetic bone material as well as anti-osteoporotic agents.

Original languageEnglish
Pages (from-to)7489-7496
Number of pages8
JournalBiomaterials
Volume33
Issue number30
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Osteoblasts
Osteoclasts
Bone
Chemical activation
Bone and Bones
Osteogenesis
Bone Resorption
Biomimetic Materials
Pinctada
NFATC Transcription Factors
JNK Mitogen-Activated Protein Kinases
Bone Remodeling
Bone Development
Osteoporosis
Actins
Biomineralization
Estrogens
Up-Regulation
T-cells
Biomimetics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Kim, Hyunsoo ; Lee, Kyunghee ; Ko, Chang Yong ; Kim, Han Sung ; Shin, Hong In ; Kim, Taesoo ; Lee, Seoung Hoon ; Jeong, Daewon. / The role of nacreous factors in preventing osteoporotic bone loss through both osteoblast activation and osteoclast inactivation. In: Biomaterials. 2012 ; Vol. 33, No. 30. pp. 7489-7496.
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The role of nacreous factors in preventing osteoporotic bone loss through both osteoblast activation and osteoclast inactivation. / Kim, Hyunsoo; Lee, Kyunghee; Ko, Chang Yong; Kim, Han Sung; Shin, Hong In; Kim, Taesoo; Lee, Seoung Hoon; Jeong, Daewon.

In: Biomaterials, Vol. 33, No. 30, 01.10.2012, p. 7489-7496.

Research output: Contribution to journalArticle

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