The role of neuroinflammation on the pathogenesis of Parkinson's disease

Young Cheul Chung, Hyuk Wan Ko, Eugene Bok, Eun Soo Park, Sue Hee Huh, Jin Han Nam, Byung Kwan Jin

Research output: Contribution to journalReview article

103 Citations (Scopus)

Abstract

Parkinson's Disease (PD) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Although the causative factors of PD remain elusive, many studies on PD animal models or humans suggest that glial activation along with neuroinflammatory processes contribute to the initiation or progression of PD. Additionally, several groups have proposed that dysfunction of the blood-brain barrier (BBB) combined with infiltration of peripheral immune cells play important roles in the degeneration of DA neurons. However, these neuroinflammatory events have only been investigated separately, and the issue of whether these phenomena are neuroprotective or neurotoxic remains controversial. We here review the current knowledge regarding the functions of these neuroinflammatory processes in the brain. Finally, we describe therapeutic strategies for the regulation of neuroinflammation with the goal of improving the symptoms of PD.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalBMB reports
Volume43
Issue number4
DOIs
Publication statusPublished - 2010 Apr

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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    Chung, Y. C., Ko, H. W., Bok, E., Park, E. S., Huh, S. H., Nam, J. H., & Jin, B. K. (2010). The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB reports, 43(4), 225-232. https://doi.org/10.5483/BMBRep.2010.43.4.225