The role of neuroinflammation on the pathogenesis of Parkinson's disease

Young Cheul Chung, Hyuk Wan Ko, Eugene Bok, Eun Soo Park, Sue Hee Huh, Jin Han Nam, Byung Kwan Jin

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

Parkinson's Disease (PD) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Although the causative factors of PD remain elusive, many studies on PD animal models or humans suggest that glial activation along with neuroinflammatory processes contribute to the initiation or progression of PD. Additionally, several groups have proposed that dysfunction of the blood-brain barrier (BBB) combined with infiltration of peripheral immune cells play important roles in the degeneration of DA neurons. However, these neuroinflammatory events have only been investigated separately, and the issue of whether these phenomena are neuroprotective or neurotoxic remains controversial. We here review the current knowledge regarding the functions of these neuroinflammatory processes in the brain. Finally, we describe therapeutic strategies for the regulation of neuroinflammation with the goal of improving the symptoms of PD.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalBMB reports
Volume43
Issue number4
DOIs
Publication statusPublished - 2010 Apr

Fingerprint

Parkinson Disease
Dopaminergic Neurons
Neurons
Neurodegenerative diseases
Blood-Brain Barrier
Infiltration
Neuroglia
Neurodegenerative Diseases
Brain
Animals
Animal Models
Chemical activation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Chung, Y. C., Ko, H. W., Bok, E., Park, E. S., Huh, S. H., Nam, J. H., & Jin, B. K. (2010). The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB reports, 43(4), 225-232. https://doi.org/10.5483/BMBRep.2010.43.4.225
Chung, Young Cheul ; Ko, Hyuk Wan ; Bok, Eugene ; Park, Eun Soo ; Huh, Sue Hee ; Nam, Jin Han ; Jin, Byung Kwan. / The role of neuroinflammation on the pathogenesis of Parkinson's disease. In: BMB reports. 2010 ; Vol. 43, No. 4. pp. 225-232.
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Chung, YC, Ko, HW, Bok, E, Park, ES, Huh, SH, Nam, JH & Jin, BK 2010, 'The role of neuroinflammation on the pathogenesis of Parkinson's disease', BMB reports, vol. 43, no. 4, pp. 225-232. https://doi.org/10.5483/BMBRep.2010.43.4.225

The role of neuroinflammation on the pathogenesis of Parkinson's disease. / Chung, Young Cheul; Ko, Hyuk Wan; Bok, Eugene; Park, Eun Soo; Huh, Sue Hee; Nam, Jin Han; Jin, Byung Kwan.

In: BMB reports, Vol. 43, No. 4, 04.2010, p. 225-232.

Research output: Contribution to journalReview article

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AU - Ko, Hyuk Wan

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AU - Jin, Byung Kwan

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