Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.
Bibliographical noteFunding Information:
This work was supported by two National Research Foundation (NRF) of Korea grants funded by the Korean government (MSIP) [ NRF-2012R1A3A1050385 to B-KK and 35B-2011-1-C00034 to H-GK]. J-IK was supported by the POSCO TJ Park Foundation . TCS was supported by NIH funding 2R37 MH057068 , RO1 MH53576 , and RO1 DA034979 .
All Science Journal Classification (ASJC) codes
- Experimental and Cognitive Psychology
- Cognitive Neuroscience
- Behavioral Neuroscience