The role of nuclear PKMζ in memory maintenance

Hyoung Gon Ko; Ji il Kim; Su Eon Sim; Tae Hyun Kim; Juyoun Yoo; Sun Lim Choi; Sung Hee Baek; Won Jin Yu; Jong Bok Yoon; Todd Charlton Sacktor; Bong Kiun Kaang

doi:10.1016/j.nlm.2016.06.010

The role of nuclear PKMζ in memory maintenance

Hyoung Gon Ko, Ji il Kim, Su Eon Sim, Tae Hyun Kim, Juyoun Yoo, Sun Lim Choi, Sung Hee Baek, Won Jin Yu, Jong Bok Yoon, Todd Charlton Sacktor, Bong Kiun Kaang

Department of Biochemistry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.

Original language	English
Pages (from-to)	50-56
Number of pages	7
Journal	Neurobiology of Learning and Memory
Volume	135
DOIs	https://doi.org/10.1016/j.nlm.2016.06.010
Publication status	Published - 2016 Nov 1

Bibliographical note

Funding Information:
This work was supported by two National Research Foundation (NRF) of Korea grants funded by the Korean government (MSIP) [ NRF-2012R1A3A1050385 to B-KK and 35B-2011-1-C00034 to H-GK]. J-IK was supported by the POSCO TJ Park Foundation . TCS was supported by NIH funding 2R37 MH057068 , RO1 MH53576 , and RO1 DA034979 .

All Science Journal Classification (ASJC) codes

Experimental and Cognitive Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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title = "The role of nuclear PKMζ in memory maintenance",

abstract = "Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.",

author = "Ko, {Hyoung Gon} and Kim, {Ji il} and Sim, {Su Eon} and Kim, {Tae Hyun} and Juyoun Yoo and Choi, {Sun Lim} and Baek, {Sung Hee} and Yu, {Won Jin} and Yoon, {Jong Bok} and Sacktor, {Todd Charlton} and Kaang, {Bong Kiun}",

note = "Funding Information: This work was supported by two National Research Foundation (NRF) of Korea grants funded by the Korean government (MSIP) [ NRF-2012R1A3A1050385 to B-KK and 35B-2011-1-C00034 to H-GK]. J-IK was supported by the POSCO TJ Park Foundation . TCS was supported by NIH funding 2R37 MH057068 , RO1 MH53576 , and RO1 DA034979 . ",

year = "2016",

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doi = "10.1016/j.nlm.2016.06.010",

language = "English",

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journal = "Neurobiology of Learning and Memory",

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AU - Ko, Hyoung Gon

AU - Kim, Ji il

AU - Sim, Su Eon

AU - Kim, Tae Hyun

AU - Yoo, Juyoun

AU - Choi, Sun Lim

AU - Baek, Sung Hee

AU - Yu, Won Jin

AU - Yoon, Jong Bok

AU - Sacktor, Todd Charlton

AU - Kaang, Bong Kiun

N1 - Funding Information: This work was supported by two National Research Foundation (NRF) of Korea grants funded by the Korean government (MSIP) [ NRF-2012R1A3A1050385 to B-KK and 35B-2011-1-C00034 to H-GK]. J-IK was supported by the POSCO TJ Park Foundation . TCS was supported by NIH funding 2R37 MH057068 , RO1 MH53576 , and RO1 DA034979 .

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Recently, protein kinase M ζ (PKMζ) has emerged as an important player for maintaining memory. It has been reported that PKMζ regulates the trafficking of GluA2 in postsynaptic membranes to maintain memory. However, there has been no study on PKMζ outside the synaptic region regarding memory maintenance. Here, we found that PKMζ is transported to the nucleus in a neural activity-dependent manner. Moreover, we found that PKMζ phosphorylates CREB-binding protein (CBP) at serine residues and that PKMζ inhibition reduces the acetylation of histone H2B and H3. Finally, we showed that the amnesic effect of PKMζ inhibition can be rescued by enhancing histone acetylation level. These results suggest the possibility that nuclear PKMζ has a crucial role in memory maintenance.

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